DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Taf5 and wda

DIOPT Version :9

Sequence 1:	NP_476957.1	Gene:	Taf5 / 47900	FlyBaseID:	FBgn0010356	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster

Alignment Length:	736	Identity:	173/736 - (23%)
Similarity:	293/736 - (39%)	Gaps:	181/736 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 QGHKQSAVTEANAAEELAKFIDDD-----SF---------DAQH-YEQAYKELRTFVEDSLDIYK 135
            |..:|.||.         |.:|.|     ||         :.|| .:|.:.....|||...:..:
  Fly    67 QNKQQFAVN---------KMLDTDLHGGNSFTFSNVQVITNNQHTVDQQFGRFSQFVEAQAEPLR 122

  Fly   136 HELSMVLYPILVQIYFKILASGLREKAKEFIEKYK---CDLDGYYI--------------EGLFN 183
            .|:.....|:|...|..:|.:.....|.|.:.||.   ..:|.|..              |..||
  Fly   123 LEMKRFYGPMLCHFYLDLLKAREPRGAVELLRKYAHLVAPVDMYDAPPPTKINGCSTTANESTFN 187

  Fly   184 LLLLSKPEELLENDL---------------VVAMEQDKFVIRMSRDSHSLFK---------RHIQ 224
            :....:.::..:.:|               :.|.|.|..|.......:.|..         .::|
  Fly   188 IRFAKEAQDTGDTELDYFMRLVQTLSGYTRLEAAESDDTVAHFRSSKYELHTTAVVVNRICAYLQ 252

  Fly   225 DRRQEVVADIVSKYLHFDTYEGMARNKLQCVATAGSHLGEAKRQDNKMRVYYGLLKEVDFQTLTT 289
            .|...::.:::..:||....|...|      |.:..||             .||..::
  Fly   253 RRGHVLIMNLLYTWLHVHIVENEQR------AFSEDHL-------------LGLTDDL------- 291

  Fly   290 PAPAPEEEDDDPDAPDRP--------------------KKKKPKKDP--LLSKKSKSDPNAPSID 332
                 |.||.:.|...:|                    .:|:|.::|  :|....|.:
  Fly   292 -----EGEDGEDDVVSKPAVTLNTRGDIRPSKSLTEKSNRKRPAEEPNIMLETDIKQE------- 344

  Fly   333 RIPLPELKDSDKLLKLK--------ALREASKRLALSKDQLPSAVFYTVLNSHQGVTCAEISDDS 389
                .|..:|.:|.||:        .|:.|::::..|:.:||.  |..:....:|:|.|.:....
  Fly   345 ----VETDESAELSKLQLNIDACLDTLKSATEQILKSQVELPR--FLRISERSRGLTSAHLDPSE 403

  Fly   390 TMLACGFGDSSVRIWSLT------------------PAKLRTLKDADSLRELDKESADINVRMLD 436
            ..:..||.:|:|::|.|.                  |.:|...  |:...|.|::|:|.:|:..:
  Fly   404 CHMLAGFDNSAVQLWQLNQSYCRGKSFYRRYPQKRCPWELNNC--ANQEEETDEDSSDEDVKCSE 466

  Fly   437 DRSGEVTRS-----------------LMGHTGPVYRCAFAPEMNLLLSCSEDSTIRLWSLLTWSC 484
            :...|..|:                 |.|||..|....|:....|:.|.|:|:|:|.|......|
  Fly   467 EERRERNRARHCKYADNSYNEYGGFQLRGHTKGVTDVRFSAHYPLMYSVSKDATMRCWRAHNLHC 531

  Fly   485 VVTYRGHVYPVWDVRFAPHGYYFVSCSYDKTARLWATDSNQALRVFVGHLSDVDCVQFHPNSNYV 549
            ...||.|.||:|.:..:|.|.|.|:.|.|.:||||:.:...||.::.||..||:||.||||.||:
  Fly   532 AAIYRSHNYPIWCLDESPVGQYVVTGSKDLSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNYI 596

  Fly   550 ATGSSDRTVRLWDNMTGQSVRLMTGHKGSVSSLAFSACGRYLASGSVDHNIIIWDLSNGSLVTTL 614
            ||||:|.:||||...:|:.:|:....:.:|:.||||..|:.||:...:..:.|:||:.|:.:..|
  Fly   597 ATGSADHSVRLWCATSGKLMRVFADCRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQLAEL 661

  Fly   615 LRHTSTVTTITFSRDGTVLAAAGLDNNLTLWDFHKVTEDYISNHITVSHHQDENDEDVYLMRTFP 679
            ..|:::::::::|.....||.|..|..|.|||..|::.  :|::.:...........|.   |..
  Fly   662 KDHSASISSLSWSTHNRHLATACSDGTLRLWDIKKLSP--MSDNSSAGSSSSATTNRVL---TVN 721

  Fly   680 SKNSPFVSLHFTRRNLLMCVG 700
            |.....|.:.:.....|.|:|
  Fly   722 SSCQRLVDVFYGTSKTLYCIG 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taf5	NP_476957.1	TAF5_NTD2	114..245	CDD:176269	30/172 (17%)
		WD40	319..674	CDD:225201	112/397 (28%)
		WD40	373..646	CDD:238121	95/307 (31%)
		WD40 repeat	380..448	CDD:293791	19/102 (19%)
		WD40 repeat	454..490	CDD:293791	10/35 (29%)
		WD40 repeat	495..531	CDD:293791	13/35 (37%)
		WD40 repeat	538..573	CDD:293791	19/34 (56%)
		WD40 repeat	579..615	CDD:293791	12/35 (34%)
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747	28/168 (17%)
		WD40	324..>700	CDD:225201	114/392 (29%)
		WD40	491..700	CDD:238121	79/210 (38%)
		WD40 repeat	501..537	CDD:293791	10/35 (29%)
		WD40 repeat	542..578	CDD:293791	13/35 (37%)
		WD40 repeat	585..619	CDD:293791	19/33 (58%)
		WD40 repeat	626..662	CDD:293791	12/35 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45473214
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D230914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19879
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950