DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Taf5 and Taf5l

DIOPT Version :9

Sequence 1:	NP_476957.1	Gene:	Taf5 / 47900	FlyBaseID:	FBgn0010356	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_006255874.1	Gene:	Taf5l / 307927	RGDID:	1310215	Length:	624	Species:	Rattus norvegicus

Alignment Length:	732	Identity:	209/732 - (28%)
Similarity:	338/732 - (46%)	Gaps:	151/732 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLEVSNINGGNGTQL-SHDKRELLCLLKLIKKYQLKSTEELLCQEANVSSVELSEISESDVQQV 64
            |..:...:.|.|...: ..|.:..:|..:::|:.:   ||:                    ||..
  Rat     6 MVFQAPGVEGQNQEAMGGRDSQTEICPHQVMKRVR---TEQ--------------------VQVA 47

  Fly    65 LGAVLGAGDANRERKHVQSPAQGHKQSAVTEANAAEELAKFIDDDS--------------FDAQH 115
            :...|      :.|::|.|  :|..:..:..:...||:|..:...|              .:.|.
  Rat    48 VSCYL------KRRQYVDS--EGPLKQGLRLSQTPEEMAANLTVQSESGCANAVSAAPCQAEPQQ 104

  Fly   116 YEQAYKELRTFVEDSLDIYKHELSMVLYPILVQIYFKILASGLREKAKEFIEKYKCDLDGYYIEG 180
            ||..:..||.|:.||...|.||:..:|||:.|.::..::.||.:...:.|..::    .|.:::.
  Rat   105 YEVQFGRLRNFLTDSDSQYSHEVMPLLYPLFVYLHLNLVQSGPKSTVESFYSRF----HGMFLQN 165

  Fly   181 ------LFNLLLLSKPEELLENDLVVAMEQDKFVIRMSRDSHSLFKRHIQDRRQEVVADIVSKYL 239
                  :..|......:::|.|..:.|...:|:|:|:..||::...|::|......:..:::.::
  Rat   166 ASQKDIIEQLQTTQTIQDILSNFQLRAFLDNKYVVRLQEDSYNYLIRYLQSDNNTALCKVLAVHI 230

  Fly   240 HFDTYEGMARNKLQCVATAGSHLGEAKRQDNKMRVYYGLLKEVDFQTLTTPAPAPEEEDDDPDAP 304
            |.|. :...|...|..|:.||...|:...                              :.||.|
  Rat   231 HLDV-QPAKRTDYQLYASGGSSRSESSSL------------------------------EPPDVP 264

  Fly   305 DRPKKKKPKKDPLLSKKSKSDPNAPSIDRIPLPELKDSDKLLKLKALREASKRLALSKDQLPSAV 369
                      :|:|..::                        .|:.|:|:.||:......|.:..
  Rat   265 ----------NPILQNEA------------------------ALEVLQESIKRVKDGPPSLTTIC 295

  Fly   370 FYTVLNSHQGVTCAEISDDSTMLACGFGDSSVRIWSLTPAKL----------RTLKDADSLRELD 424
            ||...|:.|.:..||||.||.:||.||.:|.:::|||...||          |.....|:|.|.:
  Rat   296 FYAFYNTEQLLNTAEISSDSKLLAAGFDNSCIKLWSLRSKKLKSEPHCVDTSRVRLACDTLEEEE 360

  Fly   425 KESADINVRMLDDRSGEVTRSLMGHTGPVYRCAFAPEMNLLLSCSEDSTIRLWSLLTWSCVVTYR 489
            .|..|:...|         :.|.||.||||...|..:.:.|||||||.:||.|.|.:::..|.|:
  Rat   361 SEDDDVGTEM---------KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQ 416

  Fly   490 GHVYPVWDVRFAPHGYYFVSCSYDKTARLWATDSNQALRVFVGHLSDVDCVQFHPNSNYVATGSS 554
            ||.||||||..:|:..||.|.|:|:|||||:.|....||::.|||:|||||:|||||||:||||:
  Rat   417 GHAYPVWDVDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGST 481

  Fly   555 DRTVRLWDNMTGQSVRLMTGHKGSVSSLAFSACGRYLASGSVDHNIIIWDLSNGSLVTTLLRHTS 619
            |:|||||....|.||||.|||:|.|.||:||..|:||||...|..:.:|||::|:|...|..||.
  Rat   482 DKTVRLWSAQQGNSVRLFTGHRGPVLSLSFSPNGKYLASAGEDQRLKLWDLASGTLFKELRGHTD 546

  Fly   620 TVTTITFSRDGTVLAAAGLDNNLTLWDFHKVTEDYISNHITVSHHQDENDEDVYLMRTFPSKNSP 684
            ::|::.||.|..::|:|.:||::.:||..           :...:...:.....|:..:..:.|.
  Rat   547 SITSLAFSPDSGLIASASMDNSVRVWDIR-----------STCCNTPADGSSGELVGVYTGQMSN 600

  Fly   685 FVSLHFTRRNLLMCVGL 701
            .:|:.|...|||:..|:
  Rat   601 VLSVQFMACNLLLVTGI 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taf5	NP_476957.1	TAF5_NTD2	114..245	CDD:176269	32/136 (24%)
		WD40	319..674	CDD:225201	139/364 (38%)
		WD40	373..646	CDD:238121	129/282 (46%)
		WD40 repeat	380..448	CDD:293791	24/77 (31%)
		WD40 repeat	454..490	CDD:293791	15/35 (43%)
		WD40 repeat	495..531	CDD:293791	18/35 (51%)
		WD40 repeat	538..573	CDD:293791	25/34 (74%)
		WD40 repeat	579..615	CDD:293791	16/35 (46%)
Taf5l	XP_006255874.1	TAF5_NTD2	102..236	CDD:176269	32/138 (23%)
		WD40	<292..576	CDD:225201	133/303 (44%)
		WD40 repeat	308..375	CDD:293791	24/75 (32%)
		WD40	311..616	CDD:238121	134/324 (41%)
		WD40 repeat	381..417	CDD:293791	15/35 (43%)
		WD40 repeat	422..458	CDD:293791	18/35 (51%)
		WD40 repeat	465..500	CDD:293791	25/34 (74%)
		WD40 repeat	506..542	CDD:293791	16/35 (46%)
		WD40 repeat	548..574	CDD:293791	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0263
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52000
OrthoDB	1	1.010	-	-		D230914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19879
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930