Protein Alignment Taf5 and TAF5L

DIOPT Version :10

• Sequence 1: NP_476957.1
• Gene: Taf5 / 47900
• FlyBaseID: FBgn0010356
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_055224.1
• Gene: TAF5L / 27097
• HGNCID: 17304
• Length: 589
• Species: Homo sapiens
• Alignment Length: 679
• Identity: 203/679 - (29%)
• Similarity: 321/679 - (47%)
• Gaps: 127/679 - (18%)

  Fly    53 LSEISESDVQQVLGAVLGAGDANRERKHVQSPAQGHKQSAVTEANAAEELAKFIDDDS------- 110
            :..:....:|..:...|      :.|::|.|  .|..:..:..:..|||:|..:...|
Human     1 MKRVRTEQIQMAVSCYL------KRRQYVDS--DGPLKQGLRLSQTAEEMAANLTVQSESGCANI 57

  Fly   111 -------FDAQHYEQAYKELRTFVEDSLDIYKHELSMVLYPILVQIYFKILASGLREKAKEFIEK 168
                   .:.|.||..:..||.|:.||...:.||:..:|||:.|.::..:    ::...|..:|.
Human    58 VSAAPCQAEPQQYEVQFGRLRNFLTDSDSQHSHEVMPLLYPLFVYLHLNL----VQNSPKSTVES 118

  Fly   169 YKCDLDGYYIEG------LFNLLLLSKPEELLENDLVVAMEQDKFVIRMSRDSHSLFKRHIQDRR 227
            :.....|.:::.      :..|......:::|.|..:.|...:|:|:|:..||::...|::|...
Human   119 FYSRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFKLRAFLDNKYVVRLQEDSYNYLIRYLQSDN 183

  Fly   228 QEVVADIVSKYLHFDTYEGMARNKLQCVATAGSHLGEAKRQDNKMRVYYGLLKEVDFQTLTTPAP 292
            ...:..:::.::|.|....                                 |..|:| |.....
Human   184 NTALCKVLTLHIHLDVQPA---------------------------------KRTDYQ-LYASGS 214

  Fly   293 APEEEDDDPDAPDRPKKKKPKKDPLLSKKSKSDPNAPSIDRIPLPELKDSDKLLKLKALREASKR 357
            :...|::..:.||.|       .|:|..::                        .|:.|:|:.||
Human   215 SSRSENNGLEPPDMP-------SPILQNEA------------------------ALEVLQESIKR 248

  Fly   358 LALSKDQLPSAVFYTVLNSHQGVTCAEISDDSTMLACGFGDSSVRIWSLTPAKLRTLKD------ 416
            :......|.:..||...|:.|.:..||||.||.:||.||.:|.:::|||...||::...
Human   249 VKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSR 313

  Fly   417 ----ADSLRELDKESADINVRMLDDRSGEVTRSLMGHTGPVYRCAFAPEMNLLLSCSEDSTIRLW 477
                .|.|.|.|.|         ||.:|...:.|.||.||||...|..:.:.|||||||.:||.|
Human   314 IHLACDILEEEDDE---------DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYW 369

  Fly   478 SLLTWSCVVTYRGHVYPVWDVRFAPHGYYFVSCSYDKTARLWATDSNQALRVFVGHLSDVDCVQF 542
            .|.:::..|.|:||.|||||:..:|:..||.|.|:|:|||||:.|....||::.|||:|||||:|
Human   370 DLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKF 434

  Fly   543 HPNSNYVATGSSDRTVRLWDNMTGQSVRLMTGHKGSVSSLAFSACGRYLASGSVDHNIIIWDLSN 607
            ||||||:||||:|:|||||....|.||||.|||:|.|.|||||..|:||||...|..:.:|||::
Human   435 HPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLAS 499

  Fly   608 GSLVTTLLRHTSTVTTITFSRDGTVLAAAGLDNNLTLWDFHKVTEDYISNHITVSHHQDENDEDV 672
            |:|...|..||..:|::|||.|..::|:|.:||::.:||   :...|.|.....|..:
Human   500 GTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD---IRNTYCSAPADGSSSE------- 554

  Fly   673 YLMRTFPSKNSPFVSLHFTRRNLLMCVGL 701
             |:..:..:.|..:|:.|...|||:..|:
Human   555 -LVGVYTGQMSNVLSVQFMACNLLLVTGI 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Taf5	NP_476957.1	TAF5_NTD2	114..245	CDD:176269	30/136 (22%)
		WD40	<364..646	CDD:441893	134/291 (46%)
		WD40 repeat	380..448	CDD:293791	25/77 (32%)
		WD40 repeat	454..490	CDD:293791	15/35 (43%)
		WD40 repeat	495..531	CDD:293791	17/35 (49%)
		WD40 repeat	538..573	CDD:293791	25/34 (74%)
		WD40 repeat	579..615	CDD:293791	17/35 (49%)
TAF5L	NP_055224.1	TAF5_NTD2	67..201	CDD:176269	30/137 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..230		4/25 (16%)
		WD 1	266..305		18/38 (47%)
		WD40	<272..541	CDD:441893	131/280 (47%)
		WD40 repeat	273..340	CDD:293791	25/75 (33%)
		WD 2	340..379		18/38 (47%)
		WD40 repeat	346..382	CDD:293791	15/35 (43%)
		WD 3	382..421		20/38 (53%)
		WD40 repeat	387..423	CDD:293791	17/35 (49%)
		WD 4	424..463		28/38 (74%)
		WD40 repeat	430..465	CDD:293791	25/34 (74%)
		WD 5	466..505		20/38 (53%)
		WD40 repeat	471..507	CDD:293791	17/35 (49%)
		WD 6	508..547		15/41 (37%)
		WD40 repeat	513..539	CDD:293791	11/28 (39%)