DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Taf5 and TAF5L

DIOPT Version :9

Sequence 1:	NP_476957.1	Gene:	Taf5 / 47900	FlyBaseID:	FBgn0010356	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_055224.1	Gene:	TAF5L / 27097	HGNCID:	17304	Length:	589	Species:	Homo sapiens

Alignment Length:	679	Identity:	203/679 - (29%)
Similarity:	321/679 - (47%)	Gaps:	127/679 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LSEISESDVQQVLGAVLGAGDANRERKHVQSPAQGHKQSAVTEANAAEELAKFIDDDS------- 110
            :..:....:|..:...|      :.|::|.|  .|..:..:..:..|||:|..:...|
Human     1 MKRVRTEQIQMAVSCYL------KRRQYVDS--DGPLKQGLRLSQTAEEMAANLTVQSESGCANI 57

  Fly   111 -------FDAQHYEQAYKELRTFVEDSLDIYKHELSMVLYPILVQIYFKILASGLREKAKEFIEK 168
                   .:.|.||..:..||.|:.||...:.||:..:|||:.|.::..:    ::...|..:|.
Human    58 VSAAPCQAEPQQYEVQFGRLRNFLTDSDSQHSHEVMPLLYPLFVYLHLNL----VQNSPKSTVES 118

  Fly   169 YKCDLDGYYIEG------LFNLLLLSKPEELLENDLVVAMEQDKFVIRMSRDSHSLFKRHIQDRR 227
            :.....|.:::.      :..|......:::|.|..:.|...:|:|:|:..||::...|::|...
Human   119 FYSRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFKLRAFLDNKYVVRLQEDSYNYLIRYLQSDN 183

  Fly   228 QEVVADIVSKYLHFDTYEGMARNKLQCVATAGSHLGEAKRQDNKMRVYYGLLKEVDFQTLTTPAP 292
            ...:..:::.::|.|....                                 |..|:| |.....
Human   184 NTALCKVLTLHIHLDVQPA---------------------------------KRTDYQ-LYASGS 214

  Fly   293 APEEEDDDPDAPDRPKKKKPKKDPLLSKKSKSDPNAPSIDRIPLPELKDSDKLLKLKALREASKR 357
            :...|::..:.||.|       .|:|..::                        .|:.|:|:.||
Human   215 SSRSENNGLEPPDMP-------SPILQNEA------------------------ALEVLQESIKR 248

  Fly   358 LALSKDQLPSAVFYTVLNSHQGVTCAEISDDSTMLACGFGDSSVRIWSLTPAKLRTLKD------ 416
            :......|.:..||...|:.|.:..||||.||.:||.||.:|.:::|||...||::...
Human   249 VKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSR 313

  Fly   417 ----ADSLRELDKESADINVRMLDDRSGEVTRSLMGHTGPVYRCAFAPEMNLLLSCSEDSTIRLW 477
                .|.|.|.|.|         ||.:|...:.|.||.||||...|..:.:.|||||||.:||.|
Human   314 IHLACDILEEEDDE---------DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYW 369

  Fly   478 SLLTWSCVVTYRGHVYPVWDVRFAPHGYYFVSCSYDKTARLWATDSNQALRVFVGHLSDVDCVQF 542
            .|.:::..|.|:||.|||||:..:|:..||.|.|:|:|||||:.|....||::.|||:|||||:|
Human   370 DLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKF 434

  Fly   543 HPNSNYVATGSSDRTVRLWDNMTGQSVRLMTGHKGSVSSLAFSACGRYLASGSVDHNIIIWDLSN 607
            ||||||:||||:|:|||||....|.||||.|||:|.|.|||||..|:||||...|..:.:|||::
Human   435 HPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLAS 499

  Fly   608 GSLVTTLLRHTSTVTTITFSRDGTVLAAAGLDNNLTLWDFHKVTEDYISNHITVSHHQDENDEDV 672
            |:|...|..||..:|::|||.|..::|:|.:||::.:||   :...|.|.....|..:
Human   500 GTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD---IRNTYCSAPADGSSSE------- 554

  Fly   673 YLMRTFPSKNSPFVSLHFTRRNLLMCVGL 701
             |:..:..:.|..:|:.|...|||:..|:
Human   555 -LVGVYTGQMSNVLSVQFMACNLLLVTGI 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taf5	NP_476957.1	TAF5_NTD2	114..245	CDD:176269	30/136 (22%)
		WD40	319..674	CDD:225201	144/364 (40%)
		WD40	373..646	CDD:238121	131/282 (46%)
		WD40 repeat	380..448	CDD:293791	25/77 (32%)
		WD40 repeat	454..490	CDD:293791	15/35 (43%)
		WD40 repeat	495..531	CDD:293791	17/35 (49%)
		WD40 repeat	538..573	CDD:293791	25/34 (74%)
		WD40 repeat	579..615	CDD:293791	17/35 (49%)
TAF5L	NP_055224.1	TAF5_NTD2	67..201	CDD:176269	30/137 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..230		4/25 (16%)
		WD 1	266..305		18/38 (47%)
		WD40 repeat	273..340	CDD:293791	25/75 (33%)
		WD40	276..581	CDD:238121	139/324 (43%)
		WD 2	340..379		18/38 (47%)
		WD40 repeat	346..382	CDD:293791	15/35 (43%)
		WD 3	382..421		20/38 (53%)
		WD40 repeat	387..423	CDD:293791	17/35 (49%)
		WD 4	424..463		28/38 (74%)
		WD40 repeat	430..465	CDD:293791	25/34 (74%)
		WD 5	466..505		20/38 (53%)
		WD40 repeat	471..507	CDD:293791	17/35 (49%)
		WD 6	508..547		15/41 (37%)
		WD40 repeat	513..539	CDD:293791	11/28 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0263
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52000
OrthoDB	1	1.010	-	-		D230914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19879
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1472
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.960