Protein Alignment Nmdmc and MIS1

DIOPT Version :10

• Sequence 1: NP_476929.1
• Gene: Nmdmc / 47895
• FlyBaseID: FBgn0010222
• Length: 309
• Species: Drosophila melanogaster
• Sequence 2: NP_009640.1
• Gene: MIS1 / 852378
• SGDID: S000000288
• Length: 975
• Species: Saccharomyces cerevisiae
• Alignment Length: 300
• Identity: 134/300 - (44%)
• Similarity: 187/300 - (62%)
• Gaps: 18/300 - (6%)

  Fly    10 IIDGKAIAQEVRTQLAHELKGMEAAGYP--KPHLTAVIVGEDPASEKYVANKMVACREVGISSET 72
            |:.|:.:||.:|.:...|::.::.. :|  ||.|..:.||..|.|..||..|:.|.::..:....
Yeast    37 ILSGRKLAQSIREKANDEIQAIKLK-HPNFKPTLKIIQVGARPDSSTYVRMKLKASKDSNVDCII 100

  Fly    73 KRLPASTTQEELLQLIADLNKDPQVTGILVQLPVPEHINERTICNAVDVDKDVDGFNEVNIGRTA 137
            ::|||..|:.|||:.|:|:|.|..:.|:|:|||:|.|::|.||.||||..||||||:..|.|..|
Yeast   101 EKLPAEITEVELLKKISDINDDDSIHGLLIQLPLPRHLDETTITNAVDFKKDVDGFHRYNAGELA 165

  Fly   138 L--DMEANIPATPLGVKRLLEHMKIETLGRNAVVVGRSKNVSLPMAILLHADGKYATKAMDATVT 200
            .  .....||.||.|..:|||...::..|:||||:|||..|..|:|.||        |..:||||
Yeast   166 KKGGKPYFIPCTPYGCMKLLEEAHVKLDGKNAVVLGRSSIVGNPIASLL--------KNANATVT 222

  Fly   201 ICHRYTPPKELARHCRQADIIVVAVGKPGLITKDMVKPGACVIDVGINRIKD--ESTGQFKLVGD 263
            :||.:|  :.:|....||||::.|.|.|..:..|.:|.||.|||||||.:.|  :.:|| |||||
Yeast   223 VCHSHT--RNIAEVVSQADIVIAACGIPQYVKSDWIKEGAVVIDVGINYVPDISKKSGQ-KLVGD 284

  Fly   264 VDFEEVRQVAGHITPVPGGVGPMTVAMLMHNTLKAARKQF 303
            |||:.|::...:||||||||||||||||:.|.|.||::||
Yeast   285 VDFDSVKEKTSYITPVPGGVGPMTVAMLVSNVLLAAKRQF 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdmc	NP_476929.1	FolD	7..302	CDD:439960	132/297 (44%)
MIS1	NP_009640.1	FolD	37..323	CDD:439960	132/297 (44%)
		FTHFS	345..975	CDD:460143