DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdmc and AT2G38660

DIOPT Version :9

Sequence 1:	NP_476929.1	Gene:	Nmdmc / 47895	FlyBaseID:	FBgn0010222	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	NP_001118472.1	Gene:	AT2G38660 / 818448	AraportID:	AT2G38660	Length:	352	Species:	Arabidopsis thaliana

Alignment Length:	305	Identity:	134/305 - (43%)
Similarity:	184/305 - (60%)	Gaps:	17/305 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TSNMAQIIDGKAIAQEVRTQLAHELKGMEAAGYPKPHLTAVIVGEDPASEKYVANKMVACREVGI 68
            |.....:|||..||:|:||::..|:..|:.|....|.|..|:|||...|:.||.||:.||.|.||
plant    59 TEQKTVVIDGNVIAEEIRTKIISEVGKMKKAVGKVPGLAVVLVGEQRDSQTYVRNKIKACEETGI 123

  Fly    69 SSETKRLPASTTQEELLQLIADLNKDPQVTGILVQLPVPEHINERTICNAVDVDKDVDGFNEVNI 133
            .|....||...|:.:::.::...|:|..:.|||||||:|:|:||..|.|.|.::||||||:.:|:
plant   124 KSVLAELPEDCTEGQIISVLRKFNEDTSIHGILVQLPLPQHLNESKILNMVRLEKDVDGFHPLNV 188

  Fly   134 GRTALDMEANIP----ATPLGVKRLLEHMKIETLGRNAVVVGRSKNVSLPMAILLHADGKYATKA 194
            |..|  |....|    .||.|...||....:|..|:||||:|||..|.|||::||        :.
plant   189 GNLA--MRGREPLFVSCTPKGCVELLIRTGVEIAGKNAVVIGRSNIVGLPMSLLL--------QR 243

  Fly   195 MDATVTICHRYTPPKELARHCRQADIIVVAVGKPGLITKDMVKPGACVIDVGINRIKDESTG-QF 258
            .||||:..|.:|  |:.....|:|||::.|.|.|.|:....:||||.|||||...::|.|.. .:
plant   244 HDATVSTVHAFT--KDPEHITRKADIVIAAAGIPNLVRGSWLKPGAVVIDVGTTPVEDSSCEFGY 306

  Fly   259 KLVGDVDFEEVRQVAGHITPVPGGVGPMTVAMLMHNTLKAARKQF 303
            :|||||.:||...||..||||||||||||:.||:.|||:||::.|
plant   307 RLVGDVCYEEALGVASAITPVPGGVGPMTITMLLCNTLEAAKRIF 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdmc	NP_476929.1	FolD	9..304	CDD:223268	133/300 (44%)
		THF_DHG_CYH	10..126	CDD:279147	49/115 (43%)
		THF_DHG_CYH_C	129..303	CDD:280955	79/178 (44%)
AT2G38660	NP_001118472.1	PLN02897	8..352	CDD:178485	134/305 (44%)
		THF_DHG_CYH	65..181	CDD:279147	49/115 (43%)
		NAD_bind_m-THF_DH_Cyclohyd	177..348	CDD:133448	84/182 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	108	1.000	Domainoid score	I2149
eggNOG	1	0.900	-	-		E1_COG0190
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I1035
OMA	1	1.010	-	-		QHG61254
OrthoDB	1	1.010	-	-		D1004679at2759
OrthoFinder	1	1.000	-	-		FOG0001810
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48099
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1169
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.940