DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdmc and Mthfd2

DIOPT Version :9

Sequence 1:	NP_476929.1	Gene:	Nmdmc / 47895	FlyBaseID:	FBgn0010222	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	XP_038964266.1	Gene:	Mthfd2 / 680308	RGDID:	1311313	Length:	393	Species:	Rattus norvegicus

Alignment Length:	340	Identity:	167/340 - (49%)
Similarity:	217/340 - (63%)	Gaps:	44/340 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NMAQIIDGKAIAQEVRTQLAHELKGMEAAGYPKPHLTAVIVGEDPASEKYVANKMVACREV---- 66
            |.|.:|.|:.:||:::.::..|::...|:|..:|||:.::||::|||..||.||..|..||
  Rat    34 NEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGDNPASHSYVLNKTRAAAEVAGSW 98

  Fly    67 ----------------------------------------GISSETKRLPASTTQEELLQLIADL 91
                                                    ||:|||...|||.::||||..|..|
  Rat    99 IGHSSQLRQKGRKTPGARPLTVTRADAGTSKPAASRLMSYGINSETIVKPASVSEEELLNSIRTL 163

  Fly    92 NKDPQVTGILVQLPVPEHINERTICNAVDVDKDVDGFNEVNIGRTALDMEANIPATPLGVKRLLE 156
            |.|..|.|:|||||:||||:||.|||||..|||||||:.:|:||..||..:.:||||.||..:|:
  Rat   164 NDDENVDGLLVQLPLPEHIDERKICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEILK 228

  Fly   157 HMKIETLGRNAVVVGRSKNVSLPMAILLHADGKYATKAMDATVTICHRYTPPKELARHCRQADII 221
            ...|.|||:|.||.||||||.:|:|:|||.||.:.....||||||.||:||.::|.:|...|||:
  Rat   229 RTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRHTPKEQLKKHTILADIV 293

  Fly   222 VVAVGKPGLITKDMVKPGACVIDVGINRIKDESTGQFKLVGDVDFEEVRQVAGHITPVPGGVGPM 286
            :.|.|.|.|||.||:|.||.||||||||::|..|.:.|||||||||.|::.||:|||||||||||
  Rat   294 ISAAGIPNLITADMIKEGATVIDVGINRVQDPVTAKPKLVGDVDFEGVKKKAGYITPVPGGVGPM 358

  Fly   287 TVAMLMHNTLKAARK 301
            ||||||.||:.||:|
  Rat   359 TVAMLMKNTIIAAKK 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdmc	NP_476929.1	FolD	9..304	CDD:223268	165/337 (49%)
		THF_DHG_CYH	10..126	CDD:279147	59/159 (37%)
		THF_DHG_CYH_C	129..303	CDD:280955	102/173 (59%)
Mthfd2	XP_038964266.1	FolD	38..376	CDD:223268	165/336 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	205	1.000	Domainoid score	I2823
eggNOG	1	0.900	-	-		E1_COG0190
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21321
Inparanoid	1	1.050	333	1.000	Inparanoid score	I2334
OMA	1	1.010	-	-		QHG61254
OrthoDB	1	1.010	-	-		D1004679at2759
OrthoFinder	1	1.000	-	-		FOG0001810
OrthoInspector	1	1.000	-	-		otm45853
orthoMCL	1	0.900	-	-		OOG6_100216
Panther	1	1.100	-	-	O	PTHR48099
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1169
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840