DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdmc and Mthfd2l

DIOPT Version :9

Sequence 1:	NP_476929.1	Gene:	Nmdmc / 47895	FlyBaseID:	FBgn0010222	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	XP_006535239.1	Gene:	Mthfd2l / 665563	MGIID:	1915871	Length:	366	Species:	Mus musculus

Alignment Length:	293	Identity:	160/293 - (54%)
Similarity:	210/293 - (71%)	Gaps:	0/293 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AQIIDGKAIAQEVRTQLAHELKGMEAAGYPKPHLTAVIVGEDPASEKYVANKMVACREVGISSET 72
            |.||.|..:|::::.::...::...|.|..:|||:.::||::|||..||.||:.|...|||.||.
Mouse    70 AVIISGTNMAKQIQKEIQQGVESWIALGNRRPHLSIILVGDNPASHTYVRNKIKAASAVGICSEL 134

  Fly    73 KRLPASTTQEELLQLIADLNKDPQVTGILVQLPVPEHINERTICNAVDVDKDVDGFNEVNIGRTA 137
            ...|.:.:|||||.:...||.||:|:|||||||:|:|::||||||.:..:||||||:.:||||..
Mouse   135 IIKPKNVSQEELLDITDQLNMDPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGRLC 199

  Fly   138 LDMEANIPATPLGVKRLLEHMKIETLGRNAVVVGRSKNVSLPMAILLHADGKYATKAMDATVTIC 202
            ||..:.||||...|..:::...|||.|:|.||.||||||.:|:|:|||.||::.....||||||.
Mouse   200 LDQHSLIPATASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDATVTIA 264

  Fly   203 HRYTPPKELARHCRQADIIVVAVGKPGLITKDMVKPGACVIDVGINRIKDESTGQFKLVGDVDFE 267
            |||||.::|..|.:.||||:||.|.|.|||.|||:.||.|||||||.|:|..||:.|||||||||
Mouse   265 HRYTPREQLKAHTQLADIIIVAAGIPRLITADMVREGAAVIDVGINYIQDPVTGKTKLVGDVDFE 329

  Fly   268 EVRQVAGHITPVPGGVGPMTVAMLMHNTLKAAR 300
            .|::.|..||||||||||||||||:.|||.||:
Mouse   330 AVKKKASFITPVPGGVGPMTVAMLLKNTLLAAK 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdmc	NP_476929.1	FolD	9..304	CDD:223268	159/292 (54%)
		THF_DHG_CYH	10..126	CDD:279147	52/115 (45%)
		THF_DHG_CYH_C	129..303	CDD:280955	103/172 (60%)
Mthfd2l	XP_006535239.1	FolD	72..363	CDD:223268	159/291 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837990
Domainoid	1	1.000	207	1.000	Domainoid score	I2876
eggNOG	1	0.900	-	-		E1_COG0190
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	335	1.000	Inparanoid score	I2389
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61254
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001810
OrthoInspector	1	1.000	-	-		otm43771
orthoMCL	1	0.900	-	-		OOG6_100216
Panther	1	1.100	-	-	LDO	PTHR48099
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4671
SonicParanoid	1	1.000	-	-		X1169
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790