DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdmc and Mthfd1

DIOPT Version :9

Sequence 1:	NP_476929.1	Gene:	Nmdmc / 47895	FlyBaseID:	FBgn0010222	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	XP_006240311.1	Gene:	Mthfd1 / 64300	RGDID:	708531	Length:	941	Species:	Rattus norvegicus

Alignment Length:	294	Identity:	116/294 - (39%)
Similarity:	181/294 - (61%)	Gaps:	20/294 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IAQEVRTQLAHELKGM--EAAGYPKPHLTAVIVGEDPASEKYVANKMVACREVGISSETKRLPAS 78
            :::::|.:|..::..|  :..|: .|.|..:.||:...|..|:..|:.|.:|:||.:...:||.:
  Rat    18 VSRQIRNRLKTQVTQMQEQVPGF-TPGLAILQVGDRDDSNLYINVKLKAAQEIGIKATHIKLPRT 81

  Fly    79 TTQEELLQLIADLNKDPQVTGILVQLPVPEH--INERTICNAVDVDKDVDGFNEVNIGRTAL-DM 140
            :|:.|:|:.:..||:|..|.|.:||||:...  ||...:.||:..:|||||...:|.|:.|. |:
  Rat    82 STESEVLKYVISLNEDATVHGFIVQLPLDSENSINTEAVINAIAPEKDVDGLTSINAGKLARGDL 146

  Fly   141 -EANIPATPLGVKRLLEHMKIETLGRNAVVVGRSKNVSLPMAILLHADGKYATKAMDATVTICHR 204
             :..||.||.|...|::...::..||:||||||||.|..||..||..:        :||||.||.
  Rat   147 KDCFIPCTPKGCLELIKETGVQIAGRHAVVVGRSKIVGAPMHDLLLWN--------NATVTTCHS 203

  Fly   205 YTPPKELARHCRQADIIVVAVGKPGLITKDMVKPGACVIDVGINRIKDES--TGQFKLVGDVDFE 267
            .|  .:|.:...:.||:|||.|:|.::..:.:||||.|||.|||.:.|::  .|: |:||||.::
  Rat   204 KT--ADLDKEVNKGDILVVATGQPEMVKGEWIKPGAVVIDCGINYVPDDTKPNGR-KVVGDVAYD 265

  Fly   268 EVRQVAGHITPVPGGVGPMTVAMLMHNTLKAARK 301
            |.::.|..|||||||||||||||||.:|:::|::
  Rat   266 EAKEKASFITPVPGGVGPMTVAMLMQSTVESAQR 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdmc	NP_476929.1	FolD	9..304	CDD:223268	116/294 (39%)
		THF_DHG_CYH	10..126	CDD:279147	35/113 (31%)
		THF_DHG_CYH_C	129..303	CDD:280955	78/177 (44%)
Mthfd1	XP_006240311.1	FolD	17..303	CDD:223268	116/294 (39%)
		THF_DHG_CYH	18..131	CDD:279147	35/113 (31%)
		NAD_bind_m-THF_DH_Cyclohyd	126..298	CDD:133448	82/182 (45%)
		PLN02759	315..941	CDD:178359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100216
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810