Protein Alignment Nmdmc and MTHFD2L

DIOPT Version :9

• Sequence 1: NP_476929.1
• Gene: Nmdmc / 47895
• FlyBaseID: FBgn0010222
• Length: 309
• Species: Drosophila melanogaster
• Sequence 2: XP_016863707.1
• Gene: MTHFD2L / 441024
• HGNCID: 31865
• Length: 456
• Species: Homo sapiens
• Alignment Length: 260
• Identity: 135/260 - (51%)
• Similarity: 180/260 - (69%)
• Gaps: 0/260 - (0%)

  Fly     8 AQIIDGKAIAQEVRTQLAHELKGMEAAGYPKPHLTAVIVGEDPASEKYVANKMVACREVGISSET 72
            |.||.|..:|:.::.::...::...:.|..:|||:.::||::|||..||.||:.|...|||.||.
Human   154 AIIISGTEMAKHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYVRNKIRAASAVGICSEL 218

  Fly    73 KRLPASTTQEELLQLIADLNKDPQVTGILVQLPVPEHINERTICNAVDVDKDVDGFNEVNIGRTA 137
            ...|...:|||||.:...||.||:|:|||||||:|:|::||||||.:..:||||||:.:||||..
Human   219 ILKPKDVSQEELLDVTDQLNMDPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGRLC 283

  Fly   138 LDMEANIPATPLGVKRLLEHMKIETLGRNAVVVGRSKNVSLPMAILLHADGKYATKAMDATVTIC 202
            ||..:.||||...|..:::...|:|.|:|.||.||||||.:|:|:|||.||::.....||||||.
Human   284 LDQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDATVTIA 348

  Fly   203 HRYTPPKELARHCRQADIIVVAVGKPGLITKDMVKPGACVIDVGINRIKDESTGQFKLVGDVDFE 267
            |||||.::|..|.:.||||:||.|.|.|||.||||.||.|||||||.:.|..||:.|||||||||
Human   349 HRYTPKEQLKIHTQLADIIIVAAGIPKLITSDMVKEGAAVIDVGINYVHDPVTGKTKLVGDVDFE 413

  Fly   268  267
            Human   414  413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdmc	NP_476929.1	FolD	9..304	CDD:223268	134/259 (52%)
		THF_DHG_CYH	10..126	CDD:279147	51/115 (44%)
		THF_DHG_CYH_C	129..303	CDD:280955	79/139 (57%)
MTHFD2L	XP_016863707.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147907
Domainoid	1	1.000	208	1.000	Domainoid score	I2865
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2386
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61254
OrthoDB	1	1.010	-	-		D1004679at2759
OrthoFinder	1	1.000	-	-		FOG0001810
OrthoInspector	1	1.000	-	-		otm41721
orthoMCL	1	0.900	-	-		OOG6_100216
Panther	1	1.100	-	-	LDO	PTHR48099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1169
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.910