DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdmc and mthfd1b

DIOPT Version :9

Sequence 1:	NP_476929.1	Gene:	Nmdmc / 47895	FlyBaseID:	FBgn0010222	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	NP_955823.1	Gene:	mthfd1b / 260441	ZFINID:	ZDB-GENE-020905-4	Length:	934	Species:	Danio rerio

Alignment Length:	304	Identity:	123/304 - (40%)
Similarity:	183/304 - (60%)	Gaps:	26/304 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AQIIDGKAIAQEVRTQLAHELKGMEAAGYP--KPHLTAVIVGEDPASEKYVANKMVACREVGISS 70
            ||||.||.|:.:||.:|..|::.|:.. :|  :|.|..:.||:...|..|::.|:.|..::||::
Zfish     3 AQIICGKTISAQVRERLKEEVEEMKKT-HPNFEPGLVVLQVGDRDDSNLYISMKLKAAAQIGITA 66

  Fly    71 ETKRLPASTTQEELLQLIADLNKDPQVTGILVQLPVPE-H-INERTICNAVDVDKDVDGFNEVNI 133
            ...:||.:.|:.|:||.:.::|::.::.|::||||:.. | ||...:.|:|..:|||||...:|.
Zfish    67 VHIKLPQTATETEVLQSVTEVNENSKIHGLIVQLPLDSIHTINTERVINSVAPEKDVDGLTSINA 131

  Fly   134 GRTAL-DM-EANIPATPLGVKRLLEHMKIETLGRNAVVVGRSKNVSLPMAILL---HADGKYATK 193
            |:.|. |: :..||.||.|...|::...:...|:.|||:||||.|..||..||   |
Zfish   132 GKLARGDLGDCFIPCTPNGCMELIKQTGVSLAGKRAVVIGRSKIVGAPMHDLLLWNH-------- 188

  Fly   194 AMDATVTICHRYTPPKELARHCRQADIIVVAVGKPGLITKDMVKPGACVIDVGINRIKDES--TG 256
               ||||.||..|  .:|.....:|||:|..:|||.::..|.:|.||.|||.|||.|.|.|  :|
Zfish   189 ---ATVTTCHSKT--ADLVSEVGKADILVTGIGKPEMVHGDWLKTGAEVIDCGINTIADSSRPSG 248

  Fly   257 QFKLVGDVDFEEVRQVAGHITPVPGGVGPMTVAMLMHNTLKAAR 300
            : ::||||.::..:..|..|||||||||||||||||.||:.:|:
Zfish   249 K-RVVGDVHYDSAKDRAAFITPVPGGVGPMTVAMLMKNTVLSAK 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdmc	NP_476929.1	FolD	9..304	CDD:223268	122/303 (40%)
		THF_DHG_CYH	10..126	CDD:279147	40/119 (34%)
		THF_DHG_CYH_C	129..303	CDD:280955	78/179 (44%)
mthfd1b	NP_955823.1	FolD	4..293	CDD:223268	122/303 (40%)
		THF_DHG_CYH	5..124	CDD:279147	40/119 (34%)
		NAD_bind_m-THF_DH_Cyclohyd	119..291	CDD:133448	82/185 (44%)
		PLN02759	305..934	CDD:178359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100216
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810