DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdmc and SPBC1711.04

DIOPT Version :9

Sequence 1:	NP_476929.1	Gene:	Nmdmc / 47895	FlyBaseID:	FBgn0010222	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	NP_595877.1	Gene:	SPBC1711.04 / 2539884	PomBaseID:	SPBC1711.04	Length:	320	Species:	Schizosaccharomyces pombe

Alignment Length:	342	Identity:	77/342 - (22%)
Similarity:	135/342 - (39%)	Gaps:	78/342 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SNMAQIIDGKAIAQEVRTQLAHELKGMEAAGYPKPHLTAVIVGEDPASEKYV--ANKMVACREVG 67
            ::..:::....:|:....||...:...|.|    |.|...:...|||:..|.  .||  .|.|:|
pombe    10 NHSCKVVYASRVAETFVEQLKQHVNLFEFA----PKLVGFLSNSDPAARMYADWTNK--TCTEIG 68

  Fly    68 ISSETKRLPASTTQEELLQLIADLNKDPQVTGILVQLPVPEHINERTICNAVDVDKDVDGFNEVN 132
            ...|.:.:|    :::|...|.:.|.||.|.||::..||.....::.:...|..||||:|.
pombe    69 FQYELREVP----KDDLEDAIVEANNDPSVNGIMIYFPVFNDGQDQYLQQVVSPDKDVEGL---- 125

  Fly   133 IGRTALDMEANI-------------PATPLGVKRLLEHMKI---------ETLGRNAVVVGRSKN 175
            ..:..::|..||             |.|||.:.::||::.:         ...|:...:|.||:.
pombe   126 CHKYVMNMYHNIRHLDPEKTKKSILPCTPLAIVKILEYLGVYNKIINYGNRLYGKTITIVNRSEI 190

  Fly   176 VSLPMAILLHADGKYATKAMDATVTICHRYTPPKELARHCRQADII--------------VVAVG 226
            |..|:|.||..||   .|.....:.....:|  :......::.|:.              |:..|
pombe   191 VGRPLAALLANDG---AKVYSVDIHNVQCFT--RGAGIRSKKHDVADTNFKLEDVAPISDVIICG 250

  Fly   227 KPGLITK---DMVKPGA-CVIDVGINRIKDESTGQFKLVGDVDFEEVRQVAGHITPVPGGVGPMT 287
            .|....|   ::|:.|| |:.              |....:.|...:::.||...|   .:|.:|
pombe   251 VPSANYKFPSNLVRDGAVCIC--------------FSSEKNFDAASLKEHAGIYVP---SIGKVT 298

  Fly   288 VAMLMHNTLKAARKQFD 304
            :|||:.|.::....|.:
pombe   299 IAMLLRNLIRLTSYQLN 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdmc	NP_476929.1	FolD	9..304	CDD:223268	77/336 (23%)
		THF_DHG_CYH	10..126	CDD:279147	32/117 (27%)
		THF_DHG_CYH_C	129..303	CDD:280955	42/213 (20%)
SPBC1711.04	NP_595877.1	FolD	14..317	CDD:223268	77/338 (23%)
		THF_DHG_CYH	21..123	CDD:279147	32/111 (29%)
		NAD_bind_m-THF_DH	118..315	CDD:133447	48/222 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	71	1.000	Inparanoid score	I1917
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.820