DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdmc and Mthfd1

DIOPT Version :9

Sequence 1:	NP_476929.1	Gene:	Nmdmc / 47895	FlyBaseID:	FBgn0010222	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	NP_620084.2	Gene:	Mthfd1 / 108156	MGIID:	1342005	Length:	935	Species:	Mus musculus

Alignment Length:	302	Identity:	120/302 - (39%)
Similarity:	185/302 - (61%)	Gaps:	20/302 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AQIIDGKAIAQEVRTQLAHELKGM--EAAGYPKPHLTAVIVGEDPASEKYVANKMVACREVGISS 70
            |.|::||.::.::|.:|.:::..|  :..|: .|.|..:.||:...|..|:..|:.|..|:||.:
Mouse     4 AGILNGKLVSAQIRDRLKNQVTRMQEQVPGF-TPGLAILQVGDRDDSNLYINVKLKAAEEIGIKA 67

  Fly    71 ETKRLPASTTQEELLQLIADLNKDPQVTGILVQLPVPEH--INERTICNAVDVDKDVDGFNEVNI 133
            ...:||.::|:.|:|:.:..||:|..|.|.:||||:...  ||...:.||:..:|||||...|:.
Mouse    68 THIKLPRTSTESEVLKYVISLNEDASVHGFIVQLPLDSENSINTEAVINAIAPEKDVDGLTSVSA 132

  Fly   134 GRTAL-DM-EANIPATPLGVKRLLEHMKIETLGRNAVVVGRSKNVSLPMAILLHADGKYATKAMD 196
            |:.|. |: :..||.||.|...|::...::..||:||||||||.|..||..||..:        :
Mouse   133 GKLARGDLNDCFIPCTPKGCLELIKEAGVQIAGRHAVVVGRSKIVGAPMHDLLLWN--------N 189

  Fly   197 ATVTICHRYTPPKELARHCRQADIIVVAVGKPGLITKDMVKPGACVIDVGINRIKDES--TGQFK 259
            ||||.||..|  ..|.:...:.||:|||.|:|.::..:.:||||.|||.|||.:.|::  .|: |
Mouse   190 ATVTTCHSKT--ANLDKEVNKGDILVVATGQPEMVKGEWIKPGAVVIDCGINYVPDDTKPNGR-K 251

  Fly   260 LVGDVDFEEVRQVAGHITPVPGGVGPMTVAMLMHNTLKAARK 301
            :||||.::|.::.|..|||||||||||||||||.:|:::|::
Mouse   252 VVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAQR 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdmc	NP_476929.1	FolD	9..304	CDD:223268	119/301 (40%)
		THF_DHG_CYH	10..126	CDD:279147	38/119 (32%)
		THF_DHG_CYH_C	129..303	CDD:280955	78/177 (44%)
Mthfd1	NP_620084.2	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase	1..305		120/302 (40%)
		FolD	6..294	CDD:223268	119/300 (40%)
		THF_DHG_CYH	6..125	CDD:279147	38/119 (32%)
		Substrate binding. /evidence=ECO:0000250	52..56		1/3 (33%)
		Substrate binding. /evidence=ECO:0000250	99..101		1/1 (100%)
		NAD_bind_m-THF_DH_Cyclohyd	120..292	CDD:133448	82/182 (45%)
		Substrate binding. /evidence=ECO:0000250	272..276		3/3 (100%)
		Formyltetrahydrofolate synthetase	306..935
		PLN02759	309..935	CDD:178359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100216
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810