| Sequence 1: | NP_476929.1 | Gene: | Nmdmc / 47895 | FlyBaseID: | FBgn0010222 | Length: | 309 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_006627.2 | Gene: | MTHFD2 / 10797 | HGNCID: | 7434 | Length: | 350 | Species: | Homo sapiens |
| Alignment Length: | 304 | Identity: | 171/304 - (56%) |
|---|---|---|---|
| Similarity: | 221/304 - (72%) | Gaps: | 2/304 - (0%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 6 NMAQIIDGKAIAQEVRTQLAHELKGMEAAGYPKPHLTAVIVGEDPASEKYVANKMVACREVGISS 70
Fly 71 ETKRLPASTTQEELLQLIADLNKDPQVTGILVQLPVPEHINERTICNAVDVDKDVDGFNEVNIGR 135
Fly 136 TALDMEANIPATPLGVKRLLEHMKIETLGRNAVVVGRSKNVSLPMAILLHADGKYATKAMDATVT 200
Fly 201 ICHRYTPPKELARHCRQADIIVVAVGKPGLITKDMVKPGACVIDVGINRIKDESTGQFKLVGDVD 265
Fly 266 FEEVRQVAGHITPVPGGVGPMTVAMLMHNTLKAARK--QFDDRK 307 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Nmdmc | NP_476929.1 | FolD | 9..304 | CDD:223268 | 168/296 (57%) |
| THF_DHG_CYH | 10..126 | CDD:279147 | 60/115 (52%) | ||
| THF_DHG_CYH_C | 129..303 | CDD:280955 | 104/175 (59%) | ||
| MTHFD2 | NP_006627.2 | FolD | 39..334 | CDD:223268 | 168/294 (57%) |
| THF_DHG_CYH | 39..155 | CDD:279147 | 60/115 (52%) | ||
| Substrate binding. /evidence=ECO:0000269|PubMed:27899380 | 84..88 | 2/3 (67%) | |||
| Substrate binding. /evidence=ECO:0000269|PubMed:27899380 | 131..133 | 1/1 (100%) | |||
| NAD_bind_m-THF_DH_Cyclohyd | 150..329 | CDD:133448 | 109/178 (61%) | ||
| Substrate binding. /evidence=ECO:0000269|PubMed:27899380 | 309..313 | 3/3 (100%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 208 | 1.000 | Domainoid score | I2865 |
| eggNOG | 1 | 0.900 | - | - | E1_COG0190 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H21321 | |
| Inparanoid | 1 | 1.050 | 338 | 1.000 | Inparanoid score | I2386 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S1545 |
| OMA | 1 | 1.010 | - | - | QHG61254 | |
| OrthoDB | 1 | 1.010 | - | - | D1004679at2759 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001810 | |
| OrthoInspector | 1 | 1.000 | - | - | otm41721 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_100216 | |
| Panther | 1 | 1.100 | - | - | O | PTHR48099 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R4671 |
| SonicParanoid | 1 | 1.000 | - | - | X1169 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 16 | 15.820 | |||||