DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdmc and mthfd1l

DIOPT Version :9

Sequence 1:	NP_476929.1	Gene:	Nmdmc / 47895	FlyBaseID:	FBgn0010222	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	NP_001229925.1	Gene:	mthfd1l / 100034522	ZFINID:	ZDB-GENE-041001-133	Length:	978	Species:	Danio rerio

Alignment Length:	296	Identity:	74/296 - (25%)
Similarity:	134/296 - (45%)	Gaps:	38/296 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IAQEVRTQLAHELK--GMEAAGYPKPHLTAVIVGEDPASEKYVANKMVACREVGISSETKRLPAS 78
            |.|..|    .|||  |....|. ||.|..:..|||....:  .||.:| .::|::.....||..
Zfish    81 IVQRCR----EELKSIGENNPGL-KPTLAIIQAGEDDGLLE--MNKKMA-GKIGLNVMQICLPHR 137

  Fly    79 TTQEELLQLIADLNKDPQVTGILVQLPVPEHINERTICNAVDVDKDVDGFNEVNIGRTALDMEAN 143
            .|:||:::.:..||||.:|.||.:.|  |:....:::.||:...|||||..::|:||..|..:.:
Zfish   138 CTEEEVIEEVLRLNKDSRVHGIFLHL--PQTFLSKSVRNAIKPQKDVDGVCDLNVGRVVLGDKTD 200

  Fly   144 IPATPL--GVKRLLEHMKIETLGRNAVVVGRSKNVSLPMAILLHADGKYATKAMDATVTICHRYT 206
            ...:|:  .|..||.......:|:.||:||....:.:.:..||..:|        ..:..| |::
Zfish   201 GFTSPVAGAVLELLAKHDAPLVGKMAVLVGLEGPLKVALQCLLQNNG--------MILQTC-RWS 256

  Fly   207 PPKELARHCRQADIIVVAVGKPGLITKDMVKPGACVIDVGINRIKDESTGQFKLVGDVDFEEVRQ 271
             ...|.:....:|:::........|....::||...|::|...:::........|      |.:.
Zfish   257 -STNLQKQIMDSDVVITLNTNQNHIPSTWLRPGVAAINLGSALLEEHPDSWEATV------EAQS 314

  Fly   272 VAGHITPVPGGVGPMTVAMLMHNTLKAARKQFDDRK 307
            .|        |:||:|.|..|.:.::::|:...:::
Zfish   315 AA--------GLGPLTAAFRMQHVVRSSRRWIQEQQ 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdmc	NP_476929.1	FolD	9..304	CDD:223268	74/291 (25%)
		THF_DHG_CYH	10..126	CDD:279147	36/111 (32%)
		THF_DHG_CYH_C	129..303	CDD:280955	35/175 (20%)
mthfd1l	NP_001229925.1	THF_DHG_CYH	80..183	CDD:279147	36/111 (32%)
		FolD	81..336	CDD:223268	73/288 (25%)
		NADB_Rossmann	196..335	CDD:304358	30/162 (19%)
		PLN02759	352..978	CDD:178359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100216
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810