DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdmc and mthfd2

DIOPT Version :9

Sequence 1:	NP_476929.1	Gene:	Nmdmc / 47895	FlyBaseID:	FBgn0010222	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	NP_001002181.1	Gene:	mthfd2 / 100004977	ZFINID:	ZDB-GENE-040704-20	Length:	338	Species:	Danio rerio

Alignment Length:	293	Identity:	166/293 - (56%)
Similarity:	215/293 - (73%)	Gaps:	0/293 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AQIIDGKAIAQEVRTQLAHELKGMEAAGYPKPHLTAVIVGEDPASEKYVANKMVACREVGISSET 72
            |.:|.|:.:|:::|.:...:::...:||..:|||:.|:||::|||..||.||..|..||||||||
Zfish    30 AVVISGRKLARQIRNEARDDVEEWVSAGNRRPHLSVVLVGDNPASHSYVLNKTRAAAEVGISSET 94

  Fly    73 KRLPASTTQEELLQLIADLNKDPQVTGILVQLPVPEHINERTICNAVDVDKDVDGFNEVNIGRTA 137
            ...|::.::||||.||..||.|.:|.|:|||||:|:||:||.:||||...||||||:.||:||..
Zfish    95 ILKPSNISEEELLDLIVKLNSDHRVDGLLVQLPLPDHIDERRVCNAVCPGKDVDGFHVVNVGRMC 159

  Fly   138 LDMEANIPATPLGVKRLLEHMKIETLGRNAVVVGRSKNVSLPMAILLHADGKYATKAMDATVTIC 202
            ||....:||||.||..:::...|||||:|.:|.||||||.:|:|:|||.||::.....||||||.
Zfish   160 LDQSTMLPATPWGVWEIIKRTGIETLGKNVLVAGRSKNVGMPIAMLLHTDGRHERPGGDATVTIS 224

  Fly   203 HRYTPPKELARHCRQADIIVVAVGKPGLITKDMVKPGACVIDVGINRIKDESTGQFKLVGDVDFE 267
            |||||.::|.:|.:.|||||.|.|.|.|||.||:|.||.|||||||||.|..||:.:||||||||
Zfish   225 HRYTPKEQLRQHTKIADIIVAAAGIPNLITADMIKEGAAVIDVGINRILDPMTGKNRLVGDVDFE 289

  Fly   268 EVRQVAGHITPVPGGVGPMTVAMLMHNTLKAAR 300
            .||:.|..|||||||||||||||||.||:.||:
Zfish   290 GVRKKASFITPVPGGVGPMTVAMLMKNTIIAAK 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdmc	NP_476929.1	FolD	9..304	CDD:223268	165/292 (57%)
		THF_DHG_CYH	10..126	CDD:279147	56/115 (49%)
		THF_DHG_CYH_C	129..303	CDD:280955	105/172 (61%)
mthfd2	NP_001002181.1	FolD	32..323	CDD:223268	165/291 (57%)
		THF_DHG_CYH	32..148	CDD:279147	56/115 (49%)
		NAD_bind_m-THF_DH_Cyclohyd	143..322	CDD:133448	110/178 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	209	1.000	Domainoid score	I2789
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21321
Inparanoid	1	1.050	330	1.000	Inparanoid score	I2431
OMA	1	1.010	-	-		QHG61254
OrthoDB	1	1.010	-	-		D1004679at2759
OrthoFinder	1	1.000	-	-		FOG0001810
OrthoInspector	1	1.000	-	-		otm26407
orthoMCL	1	0.900	-	-		OOG6_100216
Panther	1	1.100	-	-	O	PTHR48099
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4671
SonicParanoid	1	1.000	-	-		X1169
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	14.010