DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hbn and ESX1

DIOPT Version :9

Sequence 1:	NP_788420.1	Gene:	hbn / 47894	FlyBaseID:	FBgn0008636	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_703149.1	Gene:	ESX1 / 80712	HGNCID:	14865	Length:	406	Species:	Homo sapiens

Alignment Length:	401	Identity:	97/401 - (24%)
Similarity:	139/401 - (34%)	Gaps:	143/401 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 QESPVSRPRAVYSIDQILGNQHQIKRSDTPSEVLITHPHHGHPHHIHHLHSSNSNGSNHLSHQQQ 90
            :|:..|:|......:..:|.:..:...|...|                      .|..| ..:||
Human    44 EENTRSKPEYGTEAENNVGTEGSVPSDDQDRE----------------------GGGGH-EPEQQ 85

  Fly    91 QQHSQQQHHSQQQQQQQQLQVQAKREDSPTNTDGGLDVDNDDELSSSLNNGHDLSDMERPRKVRR 155
            |:........|||::...|:::.::|:.|..|..|.......:.:..         .:.|.:.||
Human    86 QEEPPLTKPEQQQEEPPLLELKQEQEEPPQTTVEGPQPAEGPQTAEG---------PQPPERKRR 141

  Fly   156 SRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEARVQVWFQNRRAKWRKREKFM----- 215
            .||.||.|||.:||..|:::|||||..||.||.||:|:|.|||||||||||||::.::.:
Human   142 RRTAFTQFQLQELENFFDESQYPDVVARERLAARLNLTEDRVQVWFQNRRAKWKRNQRVLMLRNT 206

  Fly   216 -NQDKAGYL-------------------------------LPEQGLPEFPLGIPLPPHG------ 242
             ..|.|..|                               ||...:|..|..:|:||..
Human   207 ATADLAHPLDMFLGGAYYAAPALDPALCVHLVPQLPRPPVLPVPPMPPRPPMVPMPPRPPIAPMP 271

  Fly   243 --LPGHPGSMQSEF-----------WPPHFALHQHFNPAAAAAAGLLPQHLMAPHYKLPNFHTLL 294
              .|..|||..:..           |||              .|.:.|...|||   :|
Human   272 PMAPVPPGSRMAPVPPGPRMAPVPPWPP--------------MAPVPPWPPMAP---VP------ 313

  Fly   295 SQYMGLSNLNGIFGAGAAAAAAAASAGYPQNLSLHAGLSAMSQV--SPPCSNSSPRESPKLVP-H 356
                            .....|....|.|           |::|  .||.:...|  .|.:.| .
Human   314 ----------------TGPPMAPVPPGPP-----------MARVPPGPPMARVPP--GPPMAPLP 349

  Fly   357 PTPPHATPPAG 367
            |.||.|..|.|
Human   350 PGPPMAPLPPG 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbn	NP_788420.1	Homeobox	156..209	CDD:278475	35/52 (67%)
ESX1	NP_703149.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..142		21/129 (16%)
		Nuclear localization signal. /evidence=ECO:0000255	138..143		2/4 (50%)
		Homeobox	142..195	CDD:278475	35/52 (67%)
		15 X 9 AA tandem repeats of P-P-x-x-P-x-P-P-x	244..378		36/169 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..364		9/22 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910