DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hbn and uncx4.1

DIOPT Version :9

Sequence 1:	NP_788420.1	Gene:	hbn / 47894	FlyBaseID:	FBgn0008636	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001018616.2	Gene:	uncx4.1 / 553947	ZFINID:	ZDB-GENE-050714-1	Length:	470	Species:	Danio rerio

Alignment Length:	461	Identity:	113/461 - (24%)
Similarity:	155/461 - (33%)	Gaps:	179/461 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LITHPH------------HGHPHHIHHLHSSNSNGSNHLSHQQQQQHSQQQHHSQQQQQQQQLQV 111
            ::.|||            .|.|:|:.|.|..:.:|                         .|||.
Zfish     6 ILEHPHAQFGGSLGSMVGMGFPYHLGHHHVYDISG-------------------------HQLQS 45

  Fly   112 QAKREDSPTNTDGGLD------VDNDDELSSS-----------LNNGHDLSDMERPR-KVRRSRT 158
            .|.   .|.:.||.|:      |.|.:.|..|           |.:|.| .|.|.|. |.||:||
Zfish    46 AAA---VPFSIDGLLNGSCSGSVANSNPLLGSGCGVNGDSQYKLGDGGD-PDKESPGCKRRRTRT 106

  Fly   159 TFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEARVQVWFQNRRAKWRKREKFMNQDKAGYL 223
            .||.:||.:||:|..::.|||||.||.||:||||.|:|||||||||||||||:|   |..|....
Zfish   107 NFTGWQLEELEKASNESHYPDVFMREALALRLDLVESRVQVWFQNRRAKWRKKE---NTKKGPGR 168

  Fly   224 LPEQGLPEFPLGIPLPPHGL----------------------------------PGHPG------ 248
            ......|....|.|:.|..:                                  ||...
Zfish   169 PAHNSHPTTCSGEPMDPEEIARRELERLEKKKRKQERKLLKSQNKLLAGELFHTPGSDSDSGVSQ 233

  Fly   249 SMQSEFWP---PHFALHQHFNPAAAAAAGLLPQHLMAPHYKLPNFHTL--------LSQYMGLSN 302
            |..||..|   |..:.|:.           ..:|:...|.:.....|:        .::..||..
Zfish   234 STDSESTPHTGPQHSAHRQ-----------QTEHICEQHARHQRASTVNETAEPMDSTRNSGLCP 287

  Fly   303 LNGIFGAGAAAAAAAASAGYPQNLSLHAGLSAMSQVSP-----PCSNSSPRESPKLVPHPTPPH- 361
            .|||..|                       |.:.:::|     ..::||||....|.....||.
Zfish   288 ANGITRA-----------------------STLQKLNPFSVESLLADSSPRRKTILDFSQLPPQR 329

  Fly   362 ------------ATPPAG--------------GNGGGGLLTGGLISTAAQSPNSAAGASSNASTP 400
                        .|.|.|              ||.|....|....::..::.|.....::.||..
Zfish   330 PLVGKGHFLLYPITQPLGFIVPQTAMKQSHDSGNSGHHCSTTDTSTSNQKNVNHLCRDNTGASDE 394

  Fly   401 VSVVTK 406
            :...||
Zfish   395 LQRETK 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbn	NP_788420.1	Homeobox	156..209	CDD:278475	35/52 (67%)
uncx4.1	NP_001018616.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..102		7/19 (37%)
		Homeobox	104..157	CDD:278475	35/52 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..185		8/30 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..289		13/100 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..470		9/46 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000