Protein Alignment hbn and PITX1

DIOPT Version :10

• Sequence 1: NP_788420.1
• Gene: hbn / 47894
• FlyBaseID: FBgn0008636
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: XP_047273274.1
• Gene: PITX1 / 5307
• HGNCID: 9004
• Length: 348
• Species: Homo sapiens
• Alignment Length: 354
• Identity: 94/354 - (26%)
• Similarity: 145/354 - (40%)
• Gaps: 79/354 - (22%)

  Fly    21 RPAPVQESPVSRPRAVYSIDQILGNQHQIKRSDTPSEVLITHPHHGHPHHIHHLHSSNSNGSNHL 85
            ||||...:|.:.|.   |:|...|.. .::|  .|..:   .|....||        :...:.||
Human    20 RPAPAPGAPAAVPT---SMDAFKGGM-SLER--LPEGL---RPPPPPPH--------DMGPAFHL 67

  Fly    86 SHQQQQQHSQQQHHSQQQQQQQQLQVQAKREDSPTNTDGGLDVDNDDELSSSLNNGHDLSDMERP 150
            :.....:...:...|:...           .:.|....||.....:|..:.....| ...|..:.
Human    68 ARPADPREPLENSASESSD-----------TELPEKERGGEPKGPEDSGAGGTGCG-GADDPAKK 120

  Fly   151 RKVRRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEARVQVWFQNRRAKWRKREKFM 215
            :|.||.||.||:.||.:||..|::.:|||:..||::|:..:|:|.||:|||:||||||||||:..
Human   121 KKQRRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQ 185

  Fly   216 NQD--KAGYLLPEQGLPEFPLGIPLPPHGLPGHPGSMQSEFWPPHFALHQHFNPAAAAAAGLLPQ 278
            ..|  |.||      :|:|. |:..|               :...:|....:|..||.:  |.|.
Human   186 QLDLCKGGY------VPQFS-GLVQP---------------YEDVYAAGYSYNNWAAKS--LAPA 226

  Fly   279 HLMAPHYKLPNFHTLLSQYMGLSNLNGI--------FGAGAAAAAAAASAGYPQNLSLHAGLSAM 335
            .|....:...|..:.||.....|..:.|        .|.||.       .|.|     ::||:.:
Human   227 PLSTKSFTFFNSMSPLSSQSMFSAPSSISSMTMPSSMGPGAV-------PGMP-----NSGLNNI 279

  Fly   336 SQVSPPCSNSSPRESPKLVPHPTPPHATP 364
            :.::....||:  .||...|:.||  |:|
Human   280 NNLTGSSLNSA--MSPGACPYGTP--ASP 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hbn	NP_788420.1	Homeodomain	154..210	CDD:459649	30/55 (55%)
PITX1	XP_047273274.1	Homeodomain	124..180	CDD:459649	30/55 (55%)
		OAR	310..327	CDD:461067