Protein Alignment hbn and OTX2

DIOPT Version :10

• Sequence 1: NP_788420.1
• Gene: hbn / 47894
• FlyBaseID: FBgn0008636
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_068374.1
• Gene: OTX2 / 5015
• HGNCID: 8522
• Length: 297
• Species: Homo sapiens
• Alignment Length: 269
• Identity: 76/269 - (28%)
• Similarity: 112/269 - (41%)
• Gaps: 68/269 - (25%)

  Fly   150 PRKVRRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEARVQVWFQNRRAKWRKREKF 214
            |||.||.|||||..||..||..|.||:|||:|.||::|::::|.|:||||||:|||||.|::::.
Human    43 PRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQ 107

  Fly   215 MNQDKAGYLLPEQGLPEFPLGIPLPPHGLPGHPGSMQSEFWPPHFALHQHFNPAAAAAAGLLPQH 279
            ........:.|.:....       |...:....|: ..:|.||      ........|:...|..
Human   108 QQNGGQNKVRPAKKKTS-------PAREVSSESGT-SGQFTPP------SSTSVPTIASSSAPVS 158

  Fly   280 LMAPHYKLPNFHTLLSQYMGLSNLNGIFGAGAA----------AAAAAASAGYPQNLSLHAGLSA 334
            :.:|              ..:|.|:......::          ..|:..|.||..:.|...|:..
Human   159 IWSP--------------ASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDC 209

  Fly   335 MSQVSPPCSNSSPRESPKLVPHPTP-PHAT-PPAGGNGGGGLLTGGLISTAAQSPNSAA----GA 393
            .|.::|             :.|..| |.|| .|.|        |..:.|...|||.|.:    ||
Human   210 GSYLTP-------------MHHQLPGPGATLSPMG--------TNAVTSHLNQSPASLSTQGYGA 253

  Fly   394 SS---NAST 399
            ||   |::|
Human   254 SSLGFNSTT 262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hbn	NP_788420.1	Homeodomain	154..210	CDD:459649	34/55 (62%)
OTX2	NP_068374.1	Homeodomain	47..102	CDD:459649	34/54 (63%)
		TF_Otx	161..242	CDD:427350	20/115 (17%)