DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hbn and Rx

DIOPT Version :9

Sequence 1:	NP_788420.1	Gene:	hbn / 47894	FlyBaseID:	FBgn0008636	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_726006.3	Gene:	Rx / 37367	FlyBaseID:	FBgn0020617	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	500	Identity:	144/500 - (28%)
Similarity:	204/500 - (40%)	Gaps:	140/500 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SQHHQHHPIMPPAMRPAP--------VQESPVSRPRAVYSIDQILGNQHQIKRSDTPSEVL---I 60
            :||.::....|....|.|        .|.:||: |..:...::.:.:...::..|..:..|   :
  Fly   345 NQHSKYAKSSPTGAGPPPPPGAYFMESQTAPVA-PSQINYDERSMSSASDLEEDDDDAAKLQLDV 408

  Fly    61 THPHHGHPH----------------HIHHLHSSNSNGSNH---------LSHQQQQQHSQQQHHS 100
            |.|....|.                :...|.:....|.|:         :.||||..|.|||  .
  Fly   409 TSPPTPSPRGQLAAKRKSAGVFCDDNEPKLANGQLPGGNYGIRPRSMEEVHHQQQSHHHQQQ--Q 471

  Fly   101 QQQQQQQQLQVQAKREDSPTNTDGG--------------LDVDNDDELSSSLNNGHDL------- 144
            ||||||||||.|...:....|:..|              |:.|:|..::.|..:..||
  Fly   472 QQQQQQQQLQQQQGFQHDFRNSGNGNPNGNSNSGDHGERLNADSDSLVNGSCASSEDLNQTNSSE 536

  Fly   145 --------SDME------RPRKVRRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEA 195
                    ||.|      ..:|.||:||||||:|||:|||||||:.||||::||:|||:::|.|.
  Fly   537 QGEKITSGSDDEGQDDNCAKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEV 601

  Fly   196 RVQVWFQNRRAKWRKREKFMNQDKAGYLLPEQGLPEF---PLGIPLPPHGLPGHPGSMQSEFWPP 257
            ||||||||||||||::||..:.        ..||..|   |..:.....|||..|       |
  Fly   602 RVQVWFQNRRAKWRRQEKSESL--------RLGLTHFTQLPHRLGCGASGLPVDP-------W-- 649

  Fly   258 HFALHQHFNPAAAAAAGLLPQHLMAPHYKLPNFHTLLSQYMGLSNLNGIFGAGAAAAAAAASAGY 322
                   .:|...:|   ||..|..|....|::   |:..:.|:..|....:.||.....|..|.
  Fly   650 -------LSPPLLSA---LPGFLSHPQTVYPSY---LTPPLSLAPGNLTMSSLAAMGHHHAHNGP 701

  Fly   323 PQNLSLHAGLSAMSQVSPPCSNSSPRESPKLVPHP------------TP------PHATPPAGGN 369
            |..   |.|.....|..||     |...|..||||            :|      ||||  :.|:
  Fly   702 PPP---HVGHGGHGQPQPP-----PPPPPHGVPHPHGSHHVVPLSHLSPHLSRMSPHAT--SLGS 756

  Fly   370 GGGGLLTGGLISTAAQSPNS-----AAGASSNASTPVSVVTKGED 409
            ...|:...|....::..|:|     |..:|.::|:..|:...|.|
  Fly   757 PHHGVTPLGTPLHSSLPPSSTATTVAVSSSQSSSSSASLECSGPD 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbn	NP_788420.1	Homeobox	156..209	CDD:278475	39/52 (75%)
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	39/51 (76%)
Rx	NP_726006.3	OAR	876..892	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I4097
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143142at50557
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020