Protein Alignment hbn and UNCX

DIOPT Version :10

• Sequence 1: NP_788420.1
• Gene: hbn / 47894
• FlyBaseID: FBgn0008636
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_001073930.1
• Gene: UNCX / 340260
• HGNCID: 33194
• Length: 531
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 132/532 - (24%)
• Similarity: 162/532 - (30%)
• Gaps: 217/532 - (40%)

  Fly    59 LITHPHH----------GHPHHIHHLHSSNSNGSNHLSHQQQQQHSQQQHHSQQQQQQQQLQVQA 113
            |:.|||.          |.|:.:.|.|.....|                         .|||..|
Human     6 LLEHPHAQFGGSLGGVVGFPYPLGHHHVYELAG-------------------------HQLQSAA 45

  Fly   114 KREDSPTNTDGGLD---------VDNDDELSSSLNNGHD-----LSDMERPRKV------RRSRT 158
            .....|.:.||.|.         |:....|.::...|.|     |||...|.|.      ||:||
Human    46 AAASVPFSIDGLLGGSCAAAASVVNPTPLLPAACGVGGDGQPFKLSDSGDPDKESPGCKRRRTRT 110

  Fly   159 TFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEARVQVWFQNRRAKWRKRE----------- 212
            .||.:||.:||:||.::.|||||.||.||:||||.|:|||||||||||||||:|
Human   111 NFTGWQLEELEKAFNESHYPDVFMREALALRLDLVESRVQVWFQNRRAKWRKKENTKKGPGRPAH 175

  Fly   213 ----------------------------KFMNQDK----------------------------AG 221
                                        |..::.|                            .|
Human   176 NSHPTTCSGEPMDPEEIARKELEKMEKKKRKHEKKLLKSQGRHLHSPGGLSLHSAPSSDSDSGGG 240

  Fly   222 YLLPEQGLPEFPLG-------------IPLPPHGLPGHPGSMQSEFWPPH--------------- 258
            .|.||...|..|..             .|.|| |.|..||:....|:|..
Human   241 GLSPEPPEPPPPAAKGPGAHASGAAGTAPAPP-GEPPAPGTCDPAFYPSQRSGAGPQPRPGRPAD 304

  Fly   259 ---------------------------FALHQHF-----------NPAAAAAAGL-----LPQHL 280
                                       |::....           |.||||||||     ||
Human   305 KDAASCGPGAAVAAVERGAAGLPKASPFSVESLLSDSPPRRKAASNAAAAAAAGLDFAPGLP--- 366

  Fly   281 MAPHYKLPNFHTLL---SQYMGL----SNLNGIFGAGAAAAAAAASAGYPQNLSLHAGLSAMSQV 338
            .||...:...|.||   :|.:|.    :.|.|..|...|...|..:...|......|...|.|..
Human   367 CAPRTLIGKGHFLLYPITQPLGFLVPQAALKGGAGLEPAPKDAPPAPAVPPAPPAQASFGAFSGP 431

  Fly   339 SPPCSNSSPRESPKLVPHPTPPHATP---------PAGGNGGGGLLTGGLISTA----AQSPNSA 390
            .....::..|.||..|..|..|...|         .|...|||.....|....|    |.||...
Human   432 GGAPDSAFARRSPDAVASPGAPAPAPAPFRDLASAAATEGGGGDCADAGTAGPAPPPPAPSPRPG 496

  Fly   391 AGASSNASTPVS 402
            ....|.|..|.:
Human   497 PRPPSPAEEPAT 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hbn	NP_788420.1	Homeodomain	154..210	CDD:459649	39/55 (71%)
UNCX	NP_001073930.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..107		5/19 (26%)
		Homeodomain	106..162	CDD:459649	39/55 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..312		20/151 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	324..344		1/19 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	401..531		26/108 (24%)