DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbn and Arx

DIOPT Version :9

Sequence 1:	NP_788420.1	Gene:	hbn / 47894	FlyBaseID:	FBgn0008636	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001093644.1	Gene:	Arx / 317268	RGDID:	1562672	Length:	566	Species:	Rattus norvegicus

Alignment Length:	494	Identity:	133/494 - (26%)
Similarity:	189/494 - (38%)	Gaps:	153/494 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TTTTSQHHQHHPIMPPAMRPAPVQESPVSRPRAVYSIDQIL----GNQHQIKRSDT--------- 54
            |.|.....:..|..|||.||...|:|..:...|..:....|    ..|..|.||.:
  Rat   118 TGTAGPRGEVPPPPPPAARPGERQDSAGAVAAAAAAAWDTLKISQAPQVSISRSKSYRENGAPFV 182

  Fly    55 -PSEVL--------ITHPHHGHPHHIHHLHSSNSNGS--------------NHLSHQQQQQHSQQ 96
             |...|        :.||.       ..|.:::..||              ..|...::.:..::
  Rat   183 PPPPALDELGGPGGVAHPE-------ERLSAASGPGSAPAAGGGTGTEEDEEELLEDEEDEDEEE 240

  Fly    97 QHHSQQQQQQQQLQVQAKRED----------------------SPTNTDGG------------LD 127
            :.....:::..:...:|..::                      :...|:||            .|
  Rat   241 ELLEDDEEELLEDDARALLKEPRRCSVATTGTVAAAAAAAAAAAAVATEGGELSPKEELLLHPED 305

  Fly   128 VD-NDDELSSSLNNGHDLSDMERPRKVRRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLD 191
            .: .|.|.|..|:.|.|..:....||.||.|||||::||.:|||||:||.||||||||:||||||
  Rat   306 AEGKDGEDSVCLSAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLD 370

  Fly   192 LSEARVQVWFQNRRAKWRKREKFMNQDKAGYLLPEQGLPEFPLGIPLPPHGLPGHPGS--MQSEF 254
            |:||||||||||||||||||||             .|....|.|:|.|......||.|  :.:..
  Rat   371 LTEARVQVWFQNRRAKWRKREK-------------AGAQTHPPGLPFPGPLSATHPLSPYLDASP 422

  Fly   255 WPPHF-ALHQHFNPAAAAAAGLLPQHLMAPHYKLPNFHTLLSQYMGLSNLNGIFGAGAAAAAAAA 318
            :|||. ||...:..||||||...|.....|                             .:|:..
  Rat   423 FPPHHPALDSAWTAAAAAAAAAFPSLPPPP-----------------------------GSASLP 458

  Fly   319 SAGYPQNLSLHAGLSAMSQ---VSP----------PCSNSSPRESPKLVPHPTPPHATPPAGGNG 370
            .:|.|..||...|.:....   :||          |.:::|  .:..|:..|||
  Rat   459 PSGAPLGLSTFLGAAVFRHPAFISPAFGRLFSTMAPLTSAS--TAAALLRQPTP----------- 510

  Fly   371 GGGLLTGGLISTAAQSPNSAAGASSNASTPVSVVTKGED 409
               .:.|.:.|.|...|.:|| |...||:..::..|.::
  Rat   511 ---AVEGAVASGALADPATAA-ADRRASSIAALRLKAKE 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbn	NP_788420.1	Homeobox	156..209	CDD:278475	43/52 (83%)
Arx	NP_001093644.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..79
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..264		24/151 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..319		8/32 (25%)
		Homeobox	336..388	CDD:278475	43/51 (84%)
		OAR	530..547	CDD:281777	3/16 (19%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	534..547		2/12 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3639
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020