DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hbn and Vsx2

DIOPT Version :9

Sequence 1:	NP_788420.1	Gene:	hbn / 47894	FlyBaseID:	FBgn0008636	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001284897.1	Gene:	Vsx2 / 31469	FlyBaseID:	FBgn0263512	Length:	645	Species:	Drosophila melanogaster

Alignment Length:	419	Identity:	113/419 - (26%)
Similarity:	165/419 - (39%)	Gaps:	90/419 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QHHQ--------HHPI-MPPAMRPA--------PVQESPVSRPRAVYSIDQILGNQHQIKRSDTP 55
            ||||        ||.: |..|.|.|        .....|.....||:...|   :|||
  Fly    91 QHHQPHHHQYREHHQMTMAAASRMAYFNAHAAVAAAFMPHQLAAAVHHHHQ---HQHQ------- 145

  Fly    56 SEVLITHPHHGHPHHIHHLHSSNSNGSNHLSHQQQQQHSQQQHHSQQQQQQQQLQVQAKREDSPT 120
                 .|||| ||||.|     .:.|........|..|....||.....|... |:::....:.|
  Fly   146 -----HHPHH-HPHHPH-----GAVGGPPPPPPMQHHHPHHPHHPLLHAQGFP-QLKSFAAGAGT 198

  Fly   121 NTDGGLDVDNDDELSSSLNNGHDLSDMERPRKVRRSRTTFTTFQLHQLERAFEKTQYPDVFTRED 185
            ...|.| ...|..:.|....|...:..::.:|.|.|||.||::||.:||.||::..||||:.||.
  Fly   199 CLPGSL-APKDFGMESLNGFGVGPNSKKKKKKRRHSRTIFTSYQLEKLEEAFKEAHYPDVYAREM 262

  Fly   186 LAMRLDLSEARVQVWFQNRRAKWRKREKFMNQDKAGYLLPEQGLPEFPLGIPLPPHGLPGHPGSM 250
            |:::.:|.|.|:|||||||||||||.||...   ...::.|.||                 .|:|
  Fly   263 LSLKTELPEDRIQVWFQNRRAKWRKTEKVWG---GSTIMAEYGL-----------------YGAM 307

  Fly   251 QSEFWPPHFALHQHFNPAAAAAAGLLPQHLMAPHYKLPNFHTLLSQYMGLSNLNGIFGAGAAAAA 315
            .....|....:.:......|.|..||.......|.|.....:.|....|:|:...         :
  Fly   308 VRHSLPLPDTILKSAKDNDAVAPWLLGMEQKCMHRKSIEAQSALKDDSGVSDHED---------S 363

  Fly   316 AAASAGYPQNLS------LHAGLSAMSQVSPPCSNSSPRESPKLVPHPTPPHATPPAGGNGGGGL 374
            |.:.:.:.::||      |.:...:::.|||     :|...|.......||.:|   .|..|..
  Fly   364 AGSKSAHSEDLSRSRCHALSSSTESLNVVSP-----APSSCPTSASTSAPPTST---SGYAGAA- 419

  Fly   375 LTGGLISTAAQSPNSAAGASSNASTPVSV 403
                  |:||.:|..|:..:|::|..:.:
  Fly   420 ------SSAATTPTGASTTNSSSSPHIEL 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbn	NP_788420.1	Homeobox	156..209	CDD:278475	31/52 (60%)
Vsx2	NP_001284897.1	Homeobox	233..286	CDD:278475	31/52 (60%)
Vsx2	NP_001284897.1	OAR	556..570	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I4097
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.920