DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hbn and rx1

DIOPT Version :9

Sequence 1:	NP_788420.1	Gene:	hbn / 47894	FlyBaseID:	FBgn0008636	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_571300.2	Gene:	rx1 / 30472	ZFINID:	ZDB-GENE-990415-236	Length:	330	Species:	Danio rerio

Alignment Length:	292	Identity:	96/292 - (32%)
Similarity:	132/292 - (45%)	Gaps:	77/292 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VYSIDQILG-NQHQIKRSDTPSEVLITHPHHGHPHHIHHLHSSNSNGSNHLSHQ-QQQQHSQQQH 98
            |:|||.||| |:.|                          .|..:.|:|.::|: ..:...:...
Zfish    36 VHSIDVILGFNKDQ--------------------------DSLLNPGANAVAHKVGGESLGEPGK 74

  Fly    99 HSQQQQQQQQLQVQAKREDSPTNTDGGL-----DVDNDD--ELSSSLNNGHDLSDMERPRKV-RR 155
            ..|:.|....|.......:.||..|..:     |.|..|  :...|.:...|.:|.|:|:|. ||
Zfish    75 LDQRVQPYGHLPPLRDGSEQPTFHDADMFSNKCDGDLGDLRKAIESDSKSPDSADGEQPKKKHRR 139

  Fly   156 SRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEARVQVWFQNRRAKWRKREKF------ 214
            :||||||:|||:|||||||:.||||::||:|||:::|.|.||||||||||||||::||.
Zfish   140 NRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKIDASTMK 204

  Fly   215 --------------------MNQDKAGYLLP-EQGLPEFPLGIPLPPHGLPGHPGSMQ--SEFWP 256
                                ||..     || :..||. ||....|.|.:||..|..|  ...:|
Zfish   205 LHDSPMLSFNRPSMHPTVGPMNNS-----LPLDPWLPS-PLSSATPVHSIPGFMGPTQGLQTGYP 263

  Fly   257 PHFALHQHFNPAAAAAAGLLPQHLMAPHYKLP 288
            .|..|    :|....|..:.|  :..|.|:.|
Zfish   264 GHSFL----SPPQPMAQSMQP--MAPPPYQCP 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbn	NP_788420.1	Homeobox	156..209	CDD:278475	39/52 (75%)
rx1	NP_571300.2	Octapeptide motif	37..44		4/6 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..104		6/37 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..142		8/23 (35%)
		Homeobox	141..193	CDD:278475	39/51 (76%)
		OAR	302..318	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	306..319
		Nuclear localization signal. /evidence=ECO:0000255	312..316
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920