DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbn and ALX3

DIOPT Version :9

Sequence 1:	NP_788420.1	Gene:	hbn / 47894	FlyBaseID:	FBgn0008636	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_006483.2	Gene:	ALX3 / 257	HGNCID:	449	Length:	343	Species:	Homo sapiens

Alignment Length:	388	Identity:	106/388 - (27%)
Similarity:	153/388 - (39%)	Gaps:	100/388 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QHHPIMPPAMRPAPVQESPVSRPRAVYSIDQILGNQHQIKRSDTPSEVLITHPHHGHPHHIHHLH 75
            |..|...|.:.|||.:...::|..|.                 .|.|..:..|......::..|.
Human    29 QGTPAAAPHLHPAPPRGPRLTRFPAC-----------------GPLEPYLPEPAKPPAKYLQDLG 76

  Fly    76 SSNSNGSNHLSHQQQQQHSQQQHHSQQQQQQQQLQVQAKREDSPTNTDG-------GLDVDNDDE 133
            ...:....|.  .:....::::........|..|..:....|.|:|..|       .|.:    .
Human    77 PGPALNGGHF--YEGPAEAEEKTSKAASFPQLPLDCRGGPRDGPSNLQGSPGPCLASLHL----P 135

  Fly   134 LSSSLNNGHDLSDMERPRKVRRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEARVQ 198
            ||..|.:..:|:  :...|.||:||||:||||.:||:.|:||.||||:.||.||:|.||:|||||
Human   136 LSPGLPDSMELA--KNKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQ 198

  Fly   199 VWFQNRRAKWRKREKF------MNQDKAGY---LLPEQGLPEFPLGIPLPPHGLPGHPGSMQSEF 254
            ||||||||||||||::      .|...|.|   :||.                ...|| .:|:..
Human   199 VWFQNRRAKWRKRERYGKIQEGRNPFTAAYDISVLPR----------------TDSHP-QLQNSL 246

  Fly   255 WPPHFALHQHFNPAAAAAAGL-------LPQHLMAPHYKLPNFHTLLSQYMGLSNLNGIFGAGAA 312
            |.         :|.:.:..|.       :|...|:| |..|  |..::.:||:
Human   247 WA---------SPGSGSPGGPCLVSPEGIPSPCMSP-YSHP--HGSVAGFMGV------------ 287

  Fly   313 AAAAAASAGYPQNLSLHAGLSAMSQVSPPCSNSSPRESPKLVPHPTPPHATPPAGGNGGGGLL 375
               .|.||.:|...|:|.....:...|...|:....:||.||.....|...|        |||
Human   288 ---PAPSAAHPGIYSIHGFPPTLGGHSFEPSSDGDYKSPSLVSLRVKPKEPP--------GLL 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbn	NP_788420.1	Homeobox	156..209	CDD:278475	38/52 (73%)
ALX3	NP_006483.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..104		13/93 (14%)
		PRK12323	<13..131	CDD:237057	19/120 (16%)
		Homeobox	157..210	CDD:365835	39/52 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.020