Protein Alignment hbn and EVX1

DIOPT Version :10

• Sequence 1: NP_788420.1
• Gene: hbn / 47894
• FlyBaseID: FBgn0008636
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_001980.1
• Gene: EVX1 / 2128
• HGNCID: 3506
• Length: 407
• Species: Homo sapiens
• Alignment Length: 427
• Identity: 98/427 - (22%)
• Similarity: 144/427 - (33%)
• Gaps: 158/427 - (37%)

  Fly    16 MPPAMRP----APVQE----------SPVSRPRA-----------VYSIDQILGNQHQIKRSDTP 55
            :|||.|.    .|.:|          .|.:.|:.           ..|:|.:.| |.|...|||.
Human    53 VPPATRERGGGGPEEEPVDGLAGSAAGPGAEPQVAGAAMLGPGPPAPSVDSLSG-QGQPSSSDTE 116

  Fly    56 S----EVLITHPHHGHPHHIHHLHSSNS---------NGSNHLSHQQQQQHSQQQHHSQQQQQQQ 107
            |    |:.::........:..:.||..|         ||.:
Human   117 SDFYEEIEVSCTPDCATGNAEYQHSKGSGSEALVGSPNGGS------------------------ 157

  Fly   108 QLQVQAKREDSPTNTDGGLDVDNDDELSSSLNNGHDLSDMERPRKVRRSRTTFTTFQLHQLERAF 172
                     ::|.:..|.....:...|:.|.::           ::||.||.||..|:.:||:.|
Human   158 ---------ETPKSNGGSGGGGSQGTLACSASD-----------QMRRYRTAFTREQIARLEKEF 202

  Fly   173 EKTQYPDVFTREDLAMRLDLSEARVQVWFQNRRAKWRKREKFMNQDKAGYLLPEQGLPEFPLGIP 237
            .:..|.....|.:||..|:|.|..::|||||||.|.:::...|..
Human   203 YRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMTW-------------------- 247

  Fly   238 LPPHGLPGHPGSMQSEFWPPHFALHQHFNPAAAAAAGL---LPQHLMAPHYKLPNFHTLLSQYMG 299
              ||  |..|            |.:.:....||||.||   .|.||..|:|. |
Human   248 --PH--PADP------------AFYTYMMSHAAAAGGLPYPFPSHLPLPYYS-P----------- 284

  Fly   300 LSNLNGIFGAGAAAAAAAASAGYPQNLSLHAGLSAMSQVSPPCSNSSPRESPKLV---PHPTPPH 361
                   .|.|||:||:||::.:..:|........:||         |...|:|:   .|  ||.
Human   285 -------VGLGAASAASAAASPFSGSLRPLDTFRVLSQ---------PYPRPELLCAFRH--PPL 331

  Fly   362 ATPPAGGNGGGGLLTGGLISTAAQSPNSAAGASSNAS 398
            ...||.|.|..   .||..|..|.....|.|.:..|:
Human   332 YPGPAHGLGAS---AGGPCSCLACHSGPANGLAPRAA 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hbn	NP_788420.1	Homeodomain	154..210	CDD:459649	25/55 (45%)
EVX1	NP_001980.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..120		17/67 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	137..179		8/74 (11%)
		Homeodomain	184..240	CDD:459649	25/55 (45%)