DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hbn and alx4

DIOPT Version :9

Sequence 1:	NP_788420.1	Gene:	hbn / 47894	FlyBaseID:	FBgn0008636	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	XP_004913406.1	Gene:	alx4 / 100493396	XenbaseID:	XB-GENE-853003	Length:	376	Species:	Xenopus tropicalis

Alignment Length:	390	Identity:	122/390 - (31%)
Similarity:	158/390 - (40%)	Gaps:	134/390 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PPAM----RPAP----VQESPVSRPRAVYSIDQILGNQHQIKRSDTPSEVLITHPHHGHPHHIHH 73
            ||||    .|||    :|.||.   ||             .:.||..|.|.:.....|
Frog    12 PPAMDCYYSPAPQGRELQTSPF---RA-------------FQPSDKFSPVFLASKGQG------- 53

  Fly    74 LHSSNSNGS----------NHLSHQQQQQHS---QQQHHSQQQQQQQQLQVQA----------KR 115
             ....|.||          |..|:..:||.|   .|.||...||||..|.:|:          |.
Frog    54 -FGDKSRGSFQQECQSLDANVQSNSGEQQGSFTKYQAHHPSHQQQQSHLYMQSTPCKSPSDSLKV 117

  Fly   116 EDSP---------------TNTD-GGLD-----------VDNDDELSSSLNNGHDLSDMERPRKV 153
            :|||               .|:| .|:|           ..:.|..|..|......|:..:.:|
Frog   118 QDSPGDPLIPCYAKESALTPNSDHQGMDSGYITSKETAGKGSQDRGSGDLPMDKTESESNKGKK- 181

  Fly   154 RRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEARVQVWFQNRRAKWRKREKF--MN 216
            ||:|||||::||.:||:.|:||.||||:.||.||||.||:|||||||||||||||||||:|  |.
Frog   182 RRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQMQ 246

  Fly   217 QDKAGYLLPEQGLPEFPL---------------------GIPLPPHGLPGHPGSMQSEFWPPHFA 260
            |.:..:    ....|.||                     |.|:|...:   |....|....||
Frog   247 QVRTHF----SSAYELPLLTRAENYAQIQNPSWIGNNGGGSPVPACVV---PCDTVSSCMSPH-- 302

  Fly   261 LHQHFNPAAAAAAGLLPQHLMAPHYKLPNFHTLLSQYMGLSNLNGIFGAGAAAAAAAASAGYPQN 325
            .|.|       :||.:.:.|..|.   |..|      :|.:::.|:||   :||......||..|
Frog   303 SHPH-------SAGGVSEFLSVPG---PGAH------VGQTHMGGLFG---SAAMGPGINGYDLN 348

Fly 326 325
Frog 349 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbn	NP_788420.1	Homeobox	156..209	CDD:278475	38/52 (73%)
alx4	XP_004913406.1	COG5576	120..266	CDD:227863	62/150 (41%)
		Homeobox	185..238	CDD:365835	39/52 (75%)
		OAR	352..370	CDD:367680
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020