DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hbn and alx4a

DIOPT Version :9

Sequence 1:	NP_788420.1	Gene:	hbn / 47894	FlyBaseID:	FBgn0008636	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	XP_001340966.1	Gene:	alx4a / 100006399	ZFINID:	ZDB-GENE-070712-3	Length:	368	Species:	Danio rerio

Alignment Length:	346	Identity:	105/346 - (30%)
Similarity:	149/346 - (43%)	Gaps:	79/346 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 YSIDQILGNQHQ------IKRSDTP-SEVLITHPHHGH--------PHHIHHLHSSNSNGSNHLS 86
            ||.....|..||      .:.|||. |...:|:...|:        ......|.::...|:.:..
Zfish    19 YSPSAPQGRDHQANPFRTFQASDTKYSPAFLTNKGQGYGEKSGSPFQQECQSLDATAGEGTFNKY 83

  Fly    87 HQQQQQHSQQQHHSQQQQQQQQL-----QVQAKREDS--------PTNTD-GGLD---------- 127
            |...|:.|.:......:.||:..     .:....:||        |.|:| .|:|
Zfish    84 HLFMQRSSCKTPPDSSKLQQENSGHNGGLIACYGKDSTGLTDSELPQNSDPAGMDGSYLSVKDSG 148

  Fly   128 VDNDDELSSSLNNGHDLSDMERPR-KVRRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLD 191
            |.:..:.:|.|.:..|.::.|..: |.||:|||||::||.:||:.|:||.||||:.||.||:|.|
Zfish   149 VKSPQQATSELASPLDKTEGESNKGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLALRTD 213

  Fly   192 LSEARVQVWFQNRRAKWRKREKF--MNQDK----AGYLLPEQGLPEFPLGIPLP--------PHG 242
            |:|||||||||||||||||||:|  |.|.:    ..|.||....||....|..|        ...
Zfish   214 LTEARVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELPLLTRPENYAQIQNPSWIGGSSAASP 278

  Fly   243 LPG--HPGSMQSEFWPPHFALHQHFNPAAAAAAGLLPQHLMAPHYKLPNFHTLLSQYMGLSNLNG 305
            :||  .|....:...|||        |.||:.   :...|..|.   |..|      ||.:::..
Zfish   279 VPGCVVPCDSVTSCMPPH--------PHAASG---VSDFLGVPS---PGSH------MGQTHMGS 323

  Fly   306 IFGAGAAAAAAAASAGYPQNL 326
            :||   :........||..|:
Zfish   324 LFG---SPGMGTGINGYDLNM 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbn	NP_788420.1	Homeobox	156..209	CDD:278475	37/52 (71%)
alx4a	XP_001340966.1	Homeobox	179..231	CDD:278475	37/51 (73%)
alx4a	XP_001340966.1	OAR	344..361	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020