DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tws and ATB BETA

DIOPT Version :9

Sequence 1:	NP_001287269.1	Gene:	tws / 47877	FlyBaseID:	FBgn0004889	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_564033.1	Gene:	ATB BETA / 838348	AraportID:	AT1G17720	Length:	501	Species:	Arabidopsis thaliana

Alignment Length:	500	Identity:	250/500 - (50%)
Similarity:	323/500 - (64%)	Gaps:	56/500 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 INGAKKPASNG---EASWCFSQIKG--ALDDDVTDADIISCVEFNHDGELLATGDKGGRVVIFQR 110
            :||....|::|   ...|.|||:.|  ...::|.:.||||.:||:..|:.|||||:|||||:|:|
plant     1 MNGGDDAATSGPPPSLEWRFSQVFGERTAGEEVQEVDIISAIEFDKSGDHLATGDRGGRVVLFER 65

  Fly   111 DPASKAANPRRG-----------EYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLQQKNPVHFL 164
            .........|:.           |:...:.|||||||||||||||||||||||||.|..|...||
plant    66 TDTKDHGGSRKDLEQTDYPVRHPEFRYKTEFQSHEPEFDYLKSLEIEEKINKIRWCQPANGALFL 130

  Fly   165 LSTNDKTVKLWKVSERD-KSFGGYNTKEE-----------NGLIRD-------------PQNVTA 204
            |||||||:|.|||.|:. |.....|....           |||..|             |..:.:
plant   131 LSTNDKTIKYWKVQEKKIKKISEMNIDPSESSNIPPQLVTNGLPADKGHDYLSKDFSFPPGGIPS 195

  Fly   205 LRVPSV--KQIPLLVEASPRRTFANAHTYHINSISVNSDQETFLSADDLRINLWHLEVVNQSYNI 267
            ||:|.|  .|...|| |..||.:|:||.|||||||.:||.|||:||||||:|||:||:.|||:||
plant   196 LRLPVVVTSQETNLV-ARCRRVYAHAHDYHINSISNSSDGETFISADDLRVNLWNLEISNQSFNI 259

  Fly   268 VDIKPTNMEELTEVITAAEFHPTECNVFVYSSSKGTIRLCDMRSAALCDRHSKQFEEPENPTNRS 332
            ||:||||||:||||||:|||||..||:..||||||:|||.|||.:||||.|:|.|||||.|.:||
plant   260 VDVKPTNMEDLTEVITSAEFHPIHCNMLAYSSSKGSIRLIDMRQSALCDSHTKLFEEPEAPGSRS 324

  Fly   333 FFSEIISSISDVKLSNSGRYMISRDYLSIKVWDLHMETKPIETYPVHEYLRAKLCSLYENDCIFD 397
            ||:|||:||||:|.|..|||::||||:::|:||::|::.|:.:|.|||:||.:||.|||||.|||
plant   325 FFTEIIASISDIKFSKDGRYILSRDYMTLKLWDINMDSGPVASYQVHEHLRPRLCDLYENDSIFD 389

  Fly   398 KFECCWNGKDSSIMTGSYNNFFRVF--DRNSKKDVTLEASRDIIKP--KTVLKP--------RKV 450
            |||||.:|....:.||||:|.||||  .:.|.:..|||||::.::.  :|..:|        |.|
plant   390 KFECCLSGDGLRVATGSYSNLFRVFGASQGSTEAATLEASKNPMRRQIQTPARPSRSIGSMTRVV 454

  Fly   451 CTGGKRKKDEISVDCLDFNKKILHTAWHPEENIIAVAATNNLFIF 495
            ..|.:....|.:.:..||..|:||.||||.||.||.||.|:|:::
plant   455 RRGSESPGTEANGNAYDFTTKLLHMAWHPTENSIACAAANSLYMY 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tws	NP_001287269.1	CDC55	65..495	CDD:227498	246/481 (51%)
		WD40	82..423	CDD:295369	211/380 (56%)
		WD40 repeat	84..132	CDD:293791	20/58 (34%)
		WD40 repeat	150..227	CDD:293791	38/103 (37%)
		WD40 repeat	233..272	CDD:293791	28/38 (74%)
		WD40 repeat	283..323	CDD:293791	26/39 (67%)
		WD40 repeat	341..377	CDD:293791	17/35 (49%)
		WD40 repeat	398..439	CDD:293791	21/42 (50%)
ATB BETA	NP_564033.1	CDC55	17..501	CDD:227498	246/483 (51%)
		WD40	37..414	CDD:295369	209/377 (55%)
		WD40 repeat	39..85	CDD:293791	18/45 (40%)
		WD40 repeat	116..219	CDD:293791	38/103 (37%)
		WD40 repeat	225..264	CDD:293791	28/38 (74%)
		WD40 repeat	275..315	CDD:293791	26/39 (67%)
		WD40 repeat	333..369	CDD:293791	17/35 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5170
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81915
Inparanoid	1	1.050	455	1.000	Inparanoid score	I379
OMA	1	1.010	-	-		QHG54269
OrthoDB	1	1.010	-	-		D810409at2759
OrthoFinder	1	1.000	-	-		FOG0000622
OrthoInspector	1	1.000	-	-		otm2618
orthoMCL	1	0.900	-	-		OOG6_100728
Panther	1	1.100	-	-	O	PTHR11871
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X368
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840