Protein Alignment tws and Ppp2r2a

DIOPT Version :10

• Sequence 1: NP_476880.1
• Gene: tws / 47877
• FlyBaseID: FBgn0004889
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_082308.1
• Gene: Ppp2r2a / 71978
• MGIID: 1919228
• Length: 447
• Species: Mus musculus
• Alignment Length: 437
• Identity: 348/437 - (79%)
• Similarity: 390/437 - (89%)
• Gaps: 0/437 - (0%)

  Fly    62 EASWCFSQIKGALDDDVTDADIISCVEFNHDGELLATGDKGGRVVIFQRDPASKAANPRRGEYNV 126
            :..|||||:|||:||||.:|||||.|||||.|||||||||||||||||::..:|..:..||||||
Mouse     9 DIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNV 73

  Fly   127 YSTFQSHEPEFDYLKSLEIEEKINKIRWLQQKNPVHFLLSTNDKTVKLWKVSERDKSFGGYNTKE 191
            |||||||||||||||||||||||||||||.|||...|||||||||:||||:|||||...|||.||
Mouse    74 YSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKE 138

  Fly   192 ENGLIRDPQNVTALRVPSVKQIPLLVEASPRRTFANAHTYHINSISVNSDQETFLSADDLRINLW 256
            |:|..|||..||.||||..:.:.|:|||||||.|||||||||||||:|||.||:|||||||||||
Mouse   139 EDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLW 203

  Fly   257 HLEVVNQSYNIVDIKPTNMEELTEVITAAEFHPTECNVFVYSSSKGTIRLCDMRSAALCDRHSKQ 321
            |||:.::|:|||||||.||||||||||||||||..||.||||||||||||||||::||||||||.
Mouse   204 HLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKL 268

  Fly   322 FEEPENPTNRSFFSEIISSISDVKLSNSGRYMISRDYLSIKVWDLHMETKPIETYPVHEYLRAKL 386
            |||||:|:||||||||||||||||.|:|||||::|||||:|:|||:||.:|:|||.||||||:||
Mouse   269 FEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKL 333

  Fly   387 CSLYENDCIFDKFECCWNGKDSSIMTGSYNNFFRVFDRNSKKDVTLEASRDIIKPKTVLKPRKVC 451
            |||||||||||||||||||.||.:||||||||||:||||:|:|:||||||:..||:|||||||||
Mouse   334 CSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVC 398

  Fly   452 TGGKRKKDEISVDCLDFNKKILHTAWHPEENIIAVAATNNLFIFQDK 498
            ..|||||||||||.||||||||||||||:|||||||.||||:|||||
Mouse   399 ASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDK 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tws	NP_476880.1	CDC55	65..495	CDD:227498	343/429 (80%)
		WD40 repeat	84..132	CDD:293791	35/47 (74%)
		WD40 repeat	150..227	CDD:293791	52/76 (68%)
		WD40 repeat	233..272	CDD:293791	30/38 (79%)
		WD40 repeat	283..323	CDD:293791	33/39 (85%)
		WD40 repeat	341..377	CDD:293791	25/35 (71%)
		WD40 repeat	398..439	CDD:293791	32/40 (80%)
Ppp2r2a	NP_082308.1	CDC55	7..442	CDD:227498	343/432 (79%)
		WD 1. /evidence=ECO:0000250|UniProtKB:P63151	11..80		51/68 (75%)
		WD40 repeat	31..79	CDD:293791	35/47 (74%)
		WD 2. /evidence=ECO:0000250|UniProtKB:P63151	94..174		55/79 (70%)
		WD40 repeat	97..174	CDD:293791	52/76 (68%)
		WD 3. /evidence=ECO:0000250|UniProtKB:P63151	175..218		34/42 (81%)
		WD40 repeat	180..216	CDD:293791	27/35 (77%)
		WD 4. /evidence=ECO:0000250|UniProtKB:P63151	227..270		36/42 (86%)
		WD40 repeat	230..281	CDD:293791	42/50 (84%)
		WD 5. /evidence=ECO:0000250|UniProtKB:P63151	288..325		26/36 (72%)
		WD40 repeat	288..324	CDD:293791	25/35 (71%)
		WD40 repeat	345..380	CDD:293791	27/34 (79%)
		WD 6. /evidence=ECO:0000250|UniProtKB:P63151	347..381		26/33 (79%)
		WD 7. /evidence=ECO:0000250|UniProtKB:P63151	414..446		29/32 (91%)
		WD40 repeat	419..442	CDD:293791	19/22 (86%)