DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tws and ppp2r2aa

DIOPT Version :9

Sequence 1:	NP_001287269.1	Gene:	tws / 47877	FlyBaseID:	FBgn0004889	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	XP_687103.5	Gene:	ppp2r2aa / 558752	ZFINID:	ZDB-GENE-130530-565	Length:	446	Species:	Danio rerio

Alignment Length:	439	Identity:	313/439 - (71%)
Similarity:	378/439 - (86%)	Gaps:	0/439 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 NGEASWCFSQIKGALDDDVTDADIISCVEFNHDGELLATGDKGGRVVIFQRDPASKAANPRRGEY 124
            :|::.||.||:|||:||||.:|||||.|||||.||||||||:|||:||||::..:|:....|.||
Zfish     6 DGQSRWCLSQVKGAVDDDVAEADIISAVEFNHSGELLATGDRGGRIVIFQQEQENKSLPQCRAEY 70

  Fly   125 NVYSTFQSHEPEFDYLKSLEIEEKINKIRWLQQKNPVHFLLSTNDKTVKLWKVSERDKSFGGYNT 189
            |||||||||||||||||||||||||||||||.|||..||||||||||:||||:|||||...|||.
Zfish    71 NVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAHFLLSTNDKTIKLWKISERDKRPEGYNL 135

  Fly   190 KEENGLIRDPQNVTALRVPSVKQIPLLVEASPRRTFANAHTYHINSISVNSDQETFLSADDLRIN 254
            |||:|..|.|.::|.||||..:.:.|:|||||||.:||||||||||||||||.||:|||||||:|
Zfish   136 KEEDGRYRHPSSLTTLRVPVFQPMDLMVEASPRRVYANAHTYHINSISVNSDNETYLSADDLRVN 200

  Fly   255 LWHLEVVNQSYNIVDIKPTNMEELTEVITAAEFHPTECNVFVYSSSKGTIRLCDMRSAALCDRHS 319
            ||||:..::|:|||||||.|||||||||||:||||.:||.|||.||||::||||||::||||:||
Zfish   201 LWHLDYTDRSFNIVDIKPANMEELTEVITASEFHPLQCNTFVYGSSKGSVRLCDMRASALCDQHS 265

  Fly   320 KQFEEPENPTNRSFFSEIISSISDVKLSNSGRYMISRDYLSIKVWDLHMETKPIETYPVHEYLRA 384
            |.|||||:|:.|||||||||||||||.|:|||||::||||::|:||||||:.|:|||.||.|||:
Zfish   266 KLFEEPEDPSTRSFFSEIISSISDVKFSHSGRYMMTRDYLTLKIWDLHMESHPVETYQVHGYLRS 330

  Fly   385 KLCSLYENDCIFDKFECCWNGKDSSIMTGSYNNFFRVFDRNSKKDVTLEASRDIIKPKTVLKPRK 449
            |||||||||||||||||||.|.||.:||||||||||:|:|..::|||||||.:...|...||..:
Zfish   331 KLCSLYENDCIFDKFECCWRGDDSEVMTGSYNNFFRMFEREGQRDVTLEASWENGSPGCPLKSWR 395

  Fly   450 VCTGGKRKKDEISVDCLDFNKKILHTAWHPEENIIAVAATNNLFIFQDK 498
            |.||.:||::||.||||||::|||:|:|||:|||:|:|..|||::||:|
Zfish   396 VSTGSRRKRNEIGVDCLDFSRKILYTSWHPQENIVALATVNNLYLFQEK 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tws	NP_001287269.1	CDC55	65..495	CDD:227498	309/429 (72%)
		WD40	82..423	CDD:295369	257/340 (76%)
		WD40 repeat	84..132	CDD:293791	32/47 (68%)
		WD40 repeat	150..227	CDD:293791	50/76 (66%)
		WD40 repeat	233..272	CDD:293791	29/38 (76%)
		WD40 repeat	283..323	CDD:293791	28/39 (72%)
		WD40 repeat	341..377	CDD:293791	25/35 (71%)
		WD40 repeat	398..439	CDD:293791	28/40 (70%)
ppp2r2aa	XP_687103.5	CDC55	11..441	CDD:227498	309/429 (72%)
		WD40	28..369	CDD:295369	257/340 (76%)
		WD40 repeat	30..78	CDD:293791	32/47 (68%)
		WD40 repeat	96..173	CDD:293791	50/76 (66%)
		WD40 repeat	179..215	CDD:293791	26/35 (74%)
		WD40 repeat	229..280	CDD:293791	36/50 (72%)
		WD40 repeat	287..323	CDD:293791	25/35 (71%)
		WD40 repeat	344..379	CDD:293791	24/34 (71%)
		WD40 repeat	418..441	CDD:293791	14/22 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595814
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54269
OrthoDB	1	1.010	-	-		D266049at33208
OrthoFinder	1	1.000	-	-		FOG0000622
OrthoInspector	1	1.000	-	-		otm24358
orthoMCL	1	0.900	-	-		OOG6_100728
Panther	1	1.100	-	-	O	PTHR11871
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X368
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.860