Protein Alignment tws and PPP2R2D

DIOPT Version :10

• Sequence 1: NP_476880.1
• Gene: tws / 47877
• FlyBaseID: FBgn0004889
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: XP_047281427.1
• Gene: PPP2R2D / 55844
• HGNCID: 23732
• Length: 454
• Species: Homo sapiens
• Alignment Length: 405
• Identity: 314/405 - (77%)
• Similarity: 359/405 - (88%)
• Gaps: 3/405 - (0%)

  Fly    97 ATGDKGGRVVI---FQRDPASKAANPRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLQQK 158
            |.|..|||..:   ......:|:....|||||||||||||||||||||||||||||||||||.|:
Human    48 ARGGFGGRNALHIGLCSSAGNKSRPHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQ 112

  Fly   159 NPVHFLLSTNDKTVKLWKVSERDKSFGGYNTKEENGLIRDPQNVTALRVPSVKQIPLLVEASPRR 223
            |..||||||||||:||||:|||||...|||.|:|:|.:|||..:||||||.:|.:.|:|||||||
Human   113 NAAHFLLSTNDKTIKLWKISERDKRAEGYNLKDEDGRLRDPFRITALRVPILKPMDLMVEASPRR 177

  Fly   224 TFANAHTYHINSISVNSDQETFLSADDLRINLWHLEVVNQSYNIVDIKPTNMEELTEVITAAEFH 288
            .|||||||||||||||||.||:||||||||||||||:.::|:|||||||.|||||||||||||||
Human   178 IFANAHTYHINSISVNSDHETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFH 242

  Fly   289 PTECNVFVYSSSKGTIRLCDMRSAALCDRHSKQFEEPENPTNRSFFSEIISSISDVKLSNSGRYM 353
            |.:||||||||||||||||||||:||||||||.|||||:|::|||||||||||||||.|:|||||
Human   243 PHQCNVFVYSSSKGTIRLCDMRSSALCDRHSKFFEEPEDPSSRSFFSEIISSISDVKFSHSGRYM 307

  Fly   354 ISRDYLSIKVWDLHMETKPIETYPVHEYLRAKLCSLYENDCIFDKFECCWNGKDSSIMTGSYNNF 418
            ::|||||:|||||:||::|:||:.||||||:|||||||||||||||||||||.||:|||||||||
Human   308 MTRDYLSVKVWDLNMESRPVETHQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSAIMTGSYNNF 372

  Fly   419 FRVFDRNSKKDVTLEASRDIIKPKTVLKPRKVCTGGKRKKDEISVDCLDFNKKILHTAWHPEENI 483
            ||:|||::::||||||||:..||:..||||||||||||:|||||||.||||||||||||||.:|:
Human   373 FRMFDRDTRRDVTLEASRESSKPRASLKPRKVCTGGKRRKDEISVDSLDFNKKILHTAWHPVDNV 437

  Fly   484 IAVAATNNLFIFQDK 498
            |||||||||:|||||
Human   438 IAVAATNNLYIFQDK 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tws	NP_476880.1	CDC55	65..495	CDD:227498	309/400 (77%)
		WD40 repeat	84..132	CDD:293791	16/37 (43%)
		WD40 repeat	150..227	CDD:293791	52/76 (68%)
		WD40 repeat	233..272	CDD:293791	31/38 (82%)
		WD40 repeat	283..323	CDD:293791	35/39 (90%)
		WD40 repeat	341..377	CDD:293791	26/35 (74%)
		WD40 repeat	398..439	CDD:293791	32/40 (80%)
PPP2R2D	XP_047281427.1	CDC55	24..449	CDD:227498	309/400 (77%)
		WD40 repeat	104..181	CDD:293791	52/76 (68%)
		WD40 repeat	187..223	CDD:293791	28/35 (80%)
		WD40 repeat	237..288	CDD:293791	43/50 (86%)
		WD40 repeat	295..331	CDD:293791	26/35 (74%)
		WD40 repeat	352..387	CDD:293791	27/34 (79%)
		WD40 repeat	426..449	CDD:293791	18/22 (82%)