DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tws and ppp2r2ab

DIOPT Version :9

Sequence 1:	NP_001287269.1	Gene:	tws / 47877	FlyBaseID:	FBgn0004889	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001296367.1	Gene:	ppp2r2ab / 327263	ZFINID:	ZDB-GENE-030131-5474	Length:	448	Species:	Danio rerio

Alignment Length:	437	Identity:	339/437 - (77%)
Similarity:	386/437 - (88%)	Gaps:	0/437 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 EASWCFSQIKGALDDDVTDADIISCVEFNHDGELLATGDKGGRVVIFQRDPASKAANPRRGEYNV 126
            :..|||||:|||:||||.:|||||.|||||.|||||||||||||||||::..:|:....|.||||
Zfish    10 DVQWCFSQVKGAIDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQETENKSQPQCRSEYNV 74

  Fly   127 YSTFQSHEPEFDYLKSLEIEEKINKIRWLQQKNPVHFLLSTNDKTVKLWKVSERDKSFGGYNTKE 191
            |||||||||||||||||||||||||||||.|||...|||||||||:||||:|||||...|||.||
Zfish    75 YSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKE 139

  Fly   192 ENGLIRDPQNVTALRVPSVKQIPLLVEASPRRTFANAHTYHINSISVNSDQETFLSADDLRINLW 256
            |:|..||...:|.||||..:.:.|:|||||||.|||||||||||||||||.||:|||||||||||
Zfish   140 EDGRYRDASTITTLRVPVFRPMDLMVEASPRRVFANAHTYHINSISVNSDNETYLSADDLRINLW 204

  Fly   257 HLEVVNQSYNIVDIKPTNMEELTEVITAAEFHPTECNVFVYSSSKGTIRLCDMRSAALCDRHSKQ 321
            |||:.::|:|||||||.|||:||||||||||||.:||.||||||||||||||||::||||:|||.
Zfish   205 HLEITDRSFNIVDIKPANMEDLTEVITAAEFHPHQCNTFVYSSSKGTIRLCDMRASALCDKHSKL 269

  Fly   322 FEEPENPTNRSFFSEIISSISDVKLSNSGRYMISRDYLSIKVWDLHMETKPIETYPVHEYLRAKL 386
            |||||:|:||||||||||||||||.|::||||::|||||:|:|||:||.:|:|||.||||||:||
Zfish   270 FEEPEDPSNRSFFSEIISSISDVKFSHNGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKL 334

  Fly   387 CSLYENDCIFDKFECCWNGKDSSIMTGSYNNFFRVFDRNSKKDVTLEASRDIIKPKTVLKPRKVC 451
            |||||||||||||||||||.||.:||||||||||:.||..::||||||||:..||:.|||||:||
Zfish   335 CSLYENDCIFDKFECCWNGNDSVVMTGSYNNFFRMLDRTQRRDVTLEASRESCKPRQVLKPRRVC 399

  Fly   452 TGGKRKKDEISVDCLDFNKKILHTAWHPEENIIAVAATNNLFIFQDK 498
            .||||||||||||.||||||||||||||:|||||||.||||:|||:|
Zfish   400 AGGKRKKDEISVDSLDFNKKILHTAWHPQENIIAVATTNNLYIFQEK 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tws	NP_001287269.1	CDC55	65..495	CDD:227498	335/429 (78%)
		WD40	82..423	CDD:295369	266/340 (78%)
		WD40 repeat	84..132	CDD:293791	34/47 (72%)
		WD40 repeat	150..227	CDD:293791	50/76 (66%)
		WD40 repeat	233..272	CDD:293791	31/38 (82%)
		WD40 repeat	283..323	CDD:293791	32/39 (82%)
		WD40 repeat	341..377	CDD:293791	24/35 (69%)
		WD40 repeat	398..439	CDD:293791	30/40 (75%)
ppp2r2ab	NP_001296367.1	CDC55	8..443	CDD:227498	335/432 (78%)
		WD40 repeat	32..80	CDD:293791	34/47 (72%)
		WD40 repeat	98..175	CDD:293791	50/76 (66%)
		WD40 repeat	181..217	CDD:293791	28/35 (80%)
		WD40 repeat	231..282	CDD:293791	41/50 (82%)
		WD40 repeat	289..325	CDD:293791	24/35 (69%)
		WD40 repeat	346..381	CDD:293791	25/34 (74%)
		WD40 repeat	420..443	CDD:293791	19/22 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595810
Domainoid	1	1.000	735	1.000	Domainoid score	I104
eggNOG	1	0.900	-	-		E1_COG5170
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	737	1.000	Inparanoid score	I583
OMA	1	1.010	-	-		QHG54269
OrthoDB	1	1.010	-	-		D266049at33208
OrthoFinder	1	1.000	-	-		FOG0000622
OrthoInspector	1	1.000	-	-		otm24358
orthoMCL	1	0.900	-	-		OOG6_100728
Panther	1	1.100	-	-	O	PTHR11871
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2
SonicParanoid	1	1.000	-	-		X368
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800