DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tws and pab1

DIOPT Version :9

Sequence 1:	NP_001287269.1	Gene:	tws / 47877	FlyBaseID:	FBgn0004889	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_592961.1	Gene:	pab1 / 2541519	PomBaseID:	SPAC227.07c	Length:	463	Species:	Schizosaccharomyces pombe

Alignment Length:	458	Identity:	241/458 - (52%)
Similarity:	321/458 - (70%)	Gaps:	35/458 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 WCFSQIKGALDD--DVTDADIISCVEFNHDGELLATGDKGGRVVIFQRDPASKAANPRRGEYNVY 127
            |.|:|..|...|  |:|:|||||.|||:|.|:.|||||||||||:|:|:.:.|..     ||..:
pombe    11 WKFAQCFGDKGDVEDITEADIISAVEFDHTGDYLATGDKGGRVVLFERNHSKKGC-----EYKFF 70

  Fly   128 STFQSHEPEFDYLKSLEIEEKINKIRWLQQKNPVHFLLSTNDKTVKLWKVSERDKSFGGYNTKEE 192
            :.|||||||||||||||||||||||||.::.|..||||||||||:||||:.|::......|...:
pombe    71 TEFQSHEPEFDYLKSLEIEEKINKIRWCKRTNRAHFLLSTNDKTIKLWKLYEKNLKVVAENNLSD 135

  Fly   193 N------GLIRDPQNVTALRVPSVKQIPLLVEASPRRTFANAHTYHINSISVNSDQETFLSADDL 251
            :      |.:..|   :.||:|.:....:::.|.|||.:||||.|||||||||||.||::|||||
pombe   136 SFHSPMQGPLTTP---SQLRLPRLNHHDMIIAAYPRRVYANAHAYHINSISVNSDAETYISADDL 197

  Fly   252 RINLWHLEVVNQSYNIVDIKPTNMEELTEVITAAEFHPTECNVFVYSSSKGTIRLCDMRSAALCD 316
            |||||:|.:.:.|:|||||||.||||||||||:|||||..||..:||||||.|:|.|:|.:||||
pombe   198 RINLWNLSISDHSFNIVDIKPENMEELTEVITSAEFHPINCNHLMYSSSKGNIKLLDLRQSALCD 262

  Fly   317 RHSKQFEEPENPTNRSFFSEIISSISDVKLSNSGRYMISRDYLSIKVWDLHMETKPIETYPVHEY 381
            ...|.||:.|:..::||||||||||||||.|.:|||::|||||::|:||::||..|::|.|:|:.
pombe   263 NPCKLFEDQEDQDSKSFFSEIISSISDVKFSQNGRYILSRDYLTLKIWDVNMEKAPVKTIPLHDV 327

  Fly   382 LRAKLCSLYENDCIFDKFECCWNGKDSSIMTGSYNNFFRVFDRNS-----KKDVTLEASRDIIKP 441
            ||:|||.|||||||||||||.::|.|..:::|||:|.|.::..:|     :..:.|:|.:...:.
pombe   328 LRSKLCDLYENDCIFDKFECTFSGDDKHVLSGSYSNNFGIYPTDSSLPGDRGQIVLQADKAAFRA 392

  Fly   442 K-----TVLKPRKVCTGGKRKKDEISV---------DCLDFNKKILHTAWHPEENIIAVAATNNL 492
            :     .|.|...|.....|.:.:.::         |.||:||||||.:|||.|:.:|:||||||
pombe   393 RKSAANNVPKLNAVKNNDWRSQPQAAMGSASVGLDPDNLDYNKKILHASWHPFEDSVAIAATNNL 457

  Fly   493 FIF 495
            |:|
pombe   458 FVF 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tws	NP_001287269.1	CDC55	65..495	CDD:227498	240/456 (53%)
		WD40	82..423	CDD:295369	204/346 (59%)
		WD40 repeat	84..132	CDD:293791	24/47 (51%)
		WD40 repeat	150..227	CDD:293791	31/82 (38%)
		WD40 repeat	233..272	CDD:293791	28/38 (74%)
		WD40 repeat	283..323	CDD:293791	23/39 (59%)
		WD40 repeat	341..377	CDD:293791	21/35 (60%)
		WD40 repeat	398..439	CDD:293791	14/45 (31%)
pab1	NP_592961.1	CDC55	4..463	CDD:227498	241/458 (53%)
		WD40	30..326	CDD:295369	178/303 (59%)
		WD40 repeat	32..75	CDD:293791	24/47 (51%)
		WD40 repeat	93..173	CDD:293791	31/82 (38%)
		WD40 repeat	179..218	CDD:293791	28/38 (74%)
		WD40 repeat	229..280	CDD:293791	27/50 (54%)
		WD40 repeat	287..336	CDD:293791	28/48 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	462	1.000	Domainoid score	I64
eggNOG	1	0.900	-	-		E1_COG5170
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81915
Inparanoid	1	1.050	474	1.000	Inparanoid score	I271
OMA	1	1.010	-	-		QHG54269
OrthoFinder	1	1.000	-	-		FOG0000622
OrthoInspector	1	1.000	-	-		oto100407
orthoMCL	1	0.900	-	-		OOG6_100728
Panther	1	1.100	-	-	LDO	PTHR11871
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2
SonicParanoid	1	1.000	-	-		X368
TreeFam	1	0.960	-	-
	13	12.950