DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zw10 and zw10

DIOPT Version :9

Sequence 1:	NP_524901.2	Gene:	Zw10 / 47874	FlyBaseID:	FBgn0004643	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001116261.1	Gene:	zw10 / 779461	XenbaseID:	XB-GENE-990692	Length:	777	Species:	Xenopus tropicalis

Alignment Length:	813	Identity:	180/813 - (22%)
Similarity:	325/813 - (39%)	Gaps:	187/813 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TRVNRFQMRVRK-------HIEDNYTEFLPNNTSPDIFLEESGSLNREIHDMLENLG--SEGLDA 92
            |:::|...||.:       .|...|.||||:       ::.:..|..::|.:..::.  ...::.
Frog    22 TKISRLSRRVEELKGEVCDMINKKYDEFLPS-------MQCAEDLVTQVHGLASDVDVLKSRIET 79

  Fly    93 LDEANVKMAGN-----GRQLREILLGLGVSEHVLRIDELFQCVEEAKATKDYLVLLDLVGRLRAF 152
            ..::::|:|.|     .:||.:..:.|||.|.:...|...:....|.|:|:|:
Frog    80 EVKSDLKVAVNEFTELKQQLEKNTVILGVLEQLQEFDSAIEKYNCALASKNYI------------ 132

  Fly   153 IYGDDSVDGDAQVATPEVRRIFKALECYETIK--------------VKYHVQAYMLQQSLQERFD 203
                           ...|.:.||..|.:.:|              ::..||...|...|.|.:.
Frog   133 ---------------SAARHLEKAHSCLKVLKSRKGCELKLLKSLGIELTVQKQNLLYHLGEEWQ 182

  Fly   204 RLVQLQCKSFPTSR---------------CVTLQVSRDQTQ---LQDIVQ--ALFQEPYNPAR-L 247
               ||.....|.|:               | ||..:.:.|.   |..::|  |:..|.....: .
Frog   183 ---QLAVWKLPPSKENSSVEMILKTELHLC-TLPSNDESTTGPLLGSVLQAFAILGELNTKLKFF 243

  Fly   248 CEFLLDNCIEPVIMRPVMADYSEEADGGTYVRLSLSYATKEPSSAQLRPNYKQVLENLRL---LL 309
            .:.||:..::|::..|.:....|....|..:|    :.:.|..|....|:  :|...|||   ||
Frog   244 SQLLLNYILKPLVTYPSLHAQMETQQQGVILR----FESVETQSEHPPPS--EVFIKLRLVFELL 302

  Fly   310 HTLAGINCSVSRDQHVFG---------IIGDHVKDKMLKLLVDECLIPAVP-ESTEEYQTSTLCE 364
            |... ::..|.....|.|         ::|:.:.:::.:.::.:||:.::| .|::..|...:..
Frog   303 HKHL-LDVPVEDSPQVSGETGKVVLAEVLGEMIWEEISEAIIKDCLVYSIPNNSSKLVQYDEVIN 366

  Fly   365 DVAQLEQLLVDSFIINPEQDRALGQFVEKYETYYRNRMYRRVLETAREIIQRDLQDMVLVAPN-- 427
            ...:.|..|.....:..:....| ::......::.::..:.|:..||.::..::.:.|.:.|:
Frog   367 ATEEFENALKGMNYLKGDATDLL-KYARNVNAHFASKKCQDVIVIARNLMTSEIHNTVKITPDSK 430

  Fly   428 -------------------NHSAEVA----ND------PFLFPRCMISKSAQDFVKLMDRILRQP 463
                               ||.::.|    ||      .|..|.|.||:|.|..::|..:.|
Frog   431 ITVPTLSKYEGSEKIIKKENHLSQEAPGLENDVKLSQHTFALPTCRISESVQKLMELAYQTL--- 492

  Fly   464 TDKLGDQEADPIAGVISIML--------HTYINEVPKVHRKLLESIPQQAVLFHNNCMFFTHWVA 520
                  .||...:...||.|        |.:.:.||..|::.|:.:||.:.:.|||||:..|.:.
Frog   493 ------SEATTSSKPCSIQLFYTVRNIFHLFYDVVPTYHKENLQKLPQLSAIHHNNCMYIAHHLL 551

  Fly   521 QHANK-----------GIESLAALAKTLQATGQQHFRVQVDYQSSILMGIM------QEFEFEST 568
            ...::           |..:...:....:..|.:.|..|:..|.:.|:..:      ...|.|..
Frog   552 TLGHQFRYHLPSPLSDGAATFVDMVPGFRRLGTESFLAQMRSQKADLLERLSNARNFSNMEDEDN 616

  Fly   569 HTLGSGPLKLVRQCLRQLELLKNVWANVLPETVYNATFCELINTFVAELIRRVFTLRDISAQMAC 633
            :|...   |.:||.:.||..|..||.:|||..:|......|:||.:.|:|.::..|.|||.:...
Frog   617 YTAAH---KAIRQVIHQLSRLGKVWQDVLPIAIYCKAMGTLLNTAIVEIISKITALEDISTEDGE 678

  Fly   634 ELSDLIDVVLQRAPTLFRE-PNEV----------VQVLSWLKLQQLKAMLNASLMEITELWGDGV 687
            .|..|...:::..|.||.. |.|.          :.|..|:|.::...:|.|||.||.:.|.||.
Frog   679 RLYTLCRTMIEEGPLLFSPIPEEAKNKKYQEEVPLYVQKWMKFKEQMIILQASLQEIVDRWADGK 743

  Fly   688 GPLTASYKSDEIKHLIRALFQDTDWRAKAITQI 720
            |||...:.:.|:|:|||||||:|:.||.|:.:|
Frog   744 GPLAVEFSTSEVKNLIRALFQNTERRAAALAKI 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zw10	NP_524901.2	Zw10	20..574	CDD:283827	123/654 (19%)
zw10	NP_001116261.1	Zw10	9..619	CDD:283827	122/651 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6663
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	149	1.000	Inparanoid score	I4280
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125408at33208
OrthoFinder	1	1.000	-	-		FOG0006350
OrthoInspector	1	1.000	-	-		oto105126
Panther	1	1.100	-	-	LDO	PTHR12205
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6070
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160