DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zw10 and Zw10

DIOPT Version :9

Sequence 1:	NP_524901.2	Gene:	Zw10 / 47874	FlyBaseID:	FBgn0004643	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001019972.1	Gene:	Zw10 / 363059	RGDID:	1309197	Length:	777	Species:	Rattus norvegicus

Alignment Length:	808	Identity:	188/808 - (23%)
Similarity:	335/808 - (41%)	Gaps:	150/808 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 NGCANVEATQSAILKVLTRVNRFQMRVRKHIEDNYTEFLPNNTSPDIFLEESGSLNREIHDMLEN 84
            :|....|...:.|.::..||...:..|...|...|:||||...|....:.:..:|:.:|..:...
  Rat    12 SGSLEKEDLGTRISRLTRRVEEIKGEVCNMISKKYSEFLPTMQSAQALVTQVDTLSNDIDQLKSR 76

  Fly    85 LGSEGLDALDEANVKMAGNGRQLR--EILLGLGVSEHVLRIDELFQCVEE---AKATKDYLVLLD 144
            :.:|....|..:.|:.....::|.  .::|.|     :.::.|....:||   |.|.|.|:....
  Rat    77 IETEVCRDLHISTVEFTNLKQRLERDSVVLNL-----LKQLQEFSSAIEEYNSALAEKKYIPAAR 136

  Fly   145 LVGRLRAFIYGDDSVDGDAQVATPEVRRIFKALECYE-----TIKVKYHVQAYMLQQSLQERFDR 204
            |:              .:||    |..::.|:.:|::     ::.::..||...:...|.|.:.:
  Rat   137 LL--------------EEAQ----ECLKLLKSKKCFDLKMLKSLSMELTVQKQNILYHLGEDWQK 183

  Fly   205 LVQLQCKSFPTSR-------CV-------TLQVSRDQTQLQDIVQALF------QEPYNPARLCE 249
            ||..:   ||.|:       |:       |.|..::.|.|..|...|.      :.|.......:
  Rat   184 LVVWK---FPPSKDTSSLESCLQTELHLCTEQPEKEMTPLPSISSVLLAFSILGELPTKLKSFGQ 245

  Fly   250 FLLDNCIEPVIMRPVMADYSEEADGGTYVRL-SLSYATKEPSSAQLRPNYKQVLENLRLLLHTL- 312
            .||...::|::..|.:....|.......:.. ||:..::.|...:.....:.|||.|:..|..|
  Rat   246 MLLKYILKPLVTCPSLHAVIERQPNSVSICFQSLATDSEHPPPPEAFAKIQLVLEVLQKQLLDLP 310

  Fly   313 --AGINCSVSRDQHVFGIIGDHVKDKMLKLLVDECLIPAVP-------------ESTEEYQTSTL 362
              |.:......:..:..::|:.:.:.:...|:..||:.::|             :||||::.|
  Rat   311 LDADLEIGKVPEIVLAEMLGEVIWEDLSDCLIRNCLVYSIPTNSSKLQQYEEIIQSTEEFEKS-- 373

  Fly   363 CEDVAQLEQLLVDSFIINPEQDRALGQFVEKYETYYRNRMYRRVLETAREIIQRDLQDMVLVAPN 427
                  |:::   .|:.....|  |.::.....:::.|:..:.|:..||.::..::.:.|.:.|:
  Rat   374 ------LKEM---RFLKGDTTD--LLKYARNINSHFANKKCQDVIVAARHLMTSEIHNTVKIGPD 427

  Fly   428 ------------------------------NHSAEVANDP--FLFPRCMISKSAQDFVKLMDRIL 460
                                          |...|.:.||  |..|.|.||::.:..::|..:.|
  Rat   428 CEETLPDLPSPDADHRLQVQVCKVQFTDAGNLEPETSLDPRSFSLPTCRISEAVKKLMELAYQTL 492

  Fly   461 RQPTDKLGDQEADPIAGVISIMLHTYINEVPKVHRKLLESIPQQAVLFHNNCMFFTHWVAQHANK 525
            .:.|.. .||.|..:...:..:.|.:.:.||..|::.|:.:||.|.:.|||||:..|.:....::
  Rat   493 LEATTS-SDQCAVQLFYSVRNIFHLFHDVVPTYHKENLQKLPQLAAIHHNNCMYIAHHLLTLGHQ 556

  Fly   526 -----------GIESLAALAKTLQATGQQHFRVQVDYQSSILMGIMQ------EFEFESTHTLGS 573
                       |..:...|....:..|.:.|..|:..|...|:..:.      ..:.|..::..|
  Rat   557 FRSRLTPILCDGTTTFVDLVPGFRRLGTECFLAQMRTQKGELLERLSSARSFANMDDEENYSAAS 621

  Fly   574 GPLKLVRQCLRQLELLKNVWANVLPETVYNATFCELINTFVAELIRRVFTLRDISAQMACELSDL 638
               |.|||.|.||:.|..||.:|||..:|......|:||.:||:|.|:..|.|||.:....|..|
  Rat   622 ---KAVRQVLHQLKRLGIVWQDVLPVNIYCKAMGTLLNTVIAEMIGRITALEDISTEDGDRLYSL 683

  Fly   639 IDVVLQRAPTLF----------REPNEV-VQVLSWLKLQQLKAMLNASLMEITELWGDGVGPLTA 692
            ...|:...|.:|          :...|| |.|..|:..::|..||.|||.||.:.|.||.|||..
  Rat   684 CKTVMDEGPQVFAPLSDENKNKKYQEEVPVYVSKWMPFKELMIMLQASLQEIGDRWADGKGPLAT 748

  Fly   693 SYKSDEIKHLIRALFQDTDWRAKAITQI 720
            ::.|.|:|.|||||||:|:.||.|:.:|
  Rat   749 AFPSSEVKALIRALFQNTERRAAALAKI 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zw10	NP_524901.2	Zw10	20..574	CDD:283827	123/649 (19%)
Zw10	NP_001019972.1	Interaction with RINT1. /evidence=ECO:0000250\|UniProtKB:O43264	2..316		66/337 (20%)
		Interaction with ZWINT. /evidence=ECO:0000250\|UniProtKB:O43264	2..81		15/68 (22%)
		Zw10	9..619	CDD:283827	146/702 (21%)
		PKc_like	<596..>766	CDD:304357	50/128 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345321
Domainoid	1	1.000	109	1.000	Domainoid score	I6261
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	173	1.000	Inparanoid score	I4000
OMA	1	1.010	-	-		QHG55465
OrthoDB	1	1.010	-	-		D125408at33208
OrthoFinder	1	1.000	-	-		FOG0006350
OrthoInspector	1	1.000	-	-		oto98432
orthoMCL	1	0.900	-	-		OOG6_104989
Panther	1	1.100	-	-	LDO	PTHR12205
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6070
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910