DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zw10 and czw-1

DIOPT Version :9

Sequence 1:	NP_524901.2	Gene:	Zw10 / 47874	FlyBaseID:	FBgn0004643	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_501327.1	Gene:	czw-1 / 177587	WormBaseID:	WBGene00017643	Length:	778	Species:	Caenorhabditis elegans

Alignment Length:	826	Identity:	158/826 - (19%)
Similarity:	309/826 - (37%)	Gaps:	209/826 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VRKHIEDNYTEFLPNNTSPDIFLEESGSLN---------REIHDMLENL------GSEGLDALDE 95
            :.|.:::..|     :.|.|| :::.|:|.         :.|.|.||||      .:..|..|.:
Worm    11 LEKKLKNGLT-----SISQDI-VDKYGNLKVSLNVNATAKLIFDRLENLEDIAEMSTRNLSNLID 69

  Fly    96 ANVKMAGNGRQLREILLGLGVSEHVLRIDELFQCVEE------AKAT------------KDYL-- 140
            ...|  .:...|.||.......|:::...:..:.|||      :|.|            ||:|
Worm    70 QTAK--DSPEMLAEIKSQAQSCENLVEFLQSMKNVEEQLIIMRSKTTNRVEWGTAILACKDFLND 132

  Fly   141 --VLLDLVGRLRAFIYGDDSVDGDAQVATPEVRRIFKALECYETIKVKYHVQAYMLQQSLQERFD 203
              :||:.:||        |..|    ::.|           .:....:|.|.:|..:..|...::
Worm   133 TNMLLEGIGR--------DGFD----MSVP-----------LKHFAAEYSVLSYNCRYQLSADYE 174

  Fly   204 RLVQLQCKSFPTSRC-----VTLQV-----SRDQTQLQDIVQALFQEPYNPARLCEFLLDNCIEP 258
            |.:.:  ......:|     |:..|     ..||..|.:.:.|:......|.||..:       .
Worm   175 RAMNV--PKLSKQKCGDRTNVSFSVFNVGSVEDQKMLNETLSAMNMIGQLPERLDAW-------K 230

  Fly   259 VIMRPVMADYSEEADGGTYVRLSLSYATKEPSSAQLR------PNYK--------QVLENLRLL- 308
            :::..|..:....:..|..|     |....|:..|.|      |..|        :|||::.:.
Worm   231 IVILNVFCEAIVASRDGVDV-----YIVDNPTPDQTRFLINQKPRGKKDKTIDVAKVLESMEVFF 290

  Fly   309 --LHTLAGINCSVSRDQHVF-GIIGDHVKDKMLKLLVDECLIPAVP--ESTEEYQTSTLCEDVAQ 368
              ||::...:..:......| .:||..::::::.:::.:.:..|.|  |:.:|.|...:  ::.|
Worm   291 TKLHSVLHSHELLDATGKTFTSMIGSVIEEQLITMILKDVIAIAAPVTETADEDQEMFI--NLLQ 353

  Fly   369 LEQLLVDSFIINPEQDRALGQFVEK--------YETYYRNRMYRRVLETAREIIQRDLQDMV--- 422
            :.::.|       |:.:.||.|.:|        .:|.:..|....::..|.::|......:|
Worm   354 IGEVFV-------ERMKELGFFSQKAKLLFTLDTDTIFVTRRCFAIVSKANKLINETYDKLVTVG 411

  Fly   423 -----------LVAPNNHSAEVAND-----------------P--FLFPRCMISKSAQDFVKLM- 456
                       |...:.|:...|.:                 |  |.|.:|.:|:|..:||.|:
Worm   412 VDDSAIKDIDLLAKAHTHAEHFAKEYGKDLGRLWSHNEDSQFPSFFAFQKCTVSESTINFVNLLR 476

  Fly   457 DRILRQPTDKLGDQEA-DPIAGVISIMLHTYINEVPKVHRKLLESIPQQAVLFHNNCMFFTHWV- 519
            |.:  :......|:.| ..:|.....::..|:...|:.|.:|..|||..|.:|:|||.:.:|.:
Worm   477 DNV--KAAFACEDEGARAKLALTAENIVRLYVILTPRKHAELFSSIPNMAAIFYNNCHYISHCIM 539

  Fly   520 -----AQHANK-------------GIESLAA--LAKTLQATGQQHFRVQVDYQSSILMGIMQEFE 564
                 |...|:             .:.::||  :.|||....::......|:  ||...:...::
Worm   540 TMSFEASGDNQKTLLEPLLLDSVIRLRTVAADCMEKTLTRCRREMTAYLEDH--SIFEHLPASYK 602

  Fly   565 -----FESTHTLGSGP-----------LKLVRQCLRQLELLKNVWANVLPETVYNATFCELINTF 613
                 |.:...:....           :|.:..||..:.|:.......|.|.||......|::..
Worm   603 TTKNTFAAAEEMSESADILVPREEPKIIKCLAACLLHIRLIAKNLREPLTEVVYCKVIGSLVSFL 667

  Fly   614 VAELIRRVFTLRDISAQMACELSDLIDVVLQRAPTL--FREPNEVVQVLS--WLKLQQLKAMLNA 674
            :..|:|.|.|..|.....|..::|:...:|:....:  ::|..:|....:  :.:|.::..:|..
Worm   668 LDSLVRHVVTTSDFRENDANVMADVFKRLLEVVANIVAYKEQTKVTDFCAREYFRLNEIVFVLGN 732

  Fly   675 SLMEITELWGDGVGPLTASYKSDEIKHLIRALFQDTDWRAKAITQI 720
            .:.:|...|.:..||:.......|:..||:|||.|:..|:..|.::
Worm   733 RMQDIEHRWFNAKGPMAEHLSRSEVVGLIKALFADSQHRSDLIARL 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zw10	NP_524901.2	Zw10	20..574	CDD:283827	124/663 (19%)
czw-1	NP_501327.1	Zw10	3..605	CDD:310684	123/651 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162186
Domainoid	1	1.000	52	1.000	Domainoid score	I7742
eggNOG	1	0.900	-	-		E1_KOG2163
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55465
OrthoDB	1	1.010	-	-		D125408at33208
OrthoFinder	1	1.000	-	-		FOG0006350
OrthoInspector	1	1.000	-	-		oto20560
orthoMCL	1	0.900	-	-		OOG6_104989
Panther	1	1.100	-	-	LDO	PTHR12205
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3777
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.790