DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and DHX34

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_055496.2	Gene:	DHX34 / 9704	HGNCID:	16719	Length:	1143	Species:	Homo sapiens

Alignment Length:	1263	Identity:	238/1263 - (18%)
Similarity:	410/1263 - (32%)	Gaps:	482/1263 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IIQDKYIPQQLLYFLAGRRCCQQFPCTF---------RTSEHE------------AFANNARSLG 47
            :::|.:..:: .|...|...||:|...|         :||..|            |.|:..|:..
Human    38 LLEDAFFREE-DYIRQGSEECQKFWTFFERLQRFQNLKTSRKEEKDPGQPKHSIPALADLPRTYD 101

  Fly    48 LRSQV-VHVNGNSC--------------VKVYKQACRHYLEEPKTLVLSSGATLNMFTLLSRKSL 97
            .|.:: :.|.|.:.              |..:::|..|||:                  ..:|..
Human   102 PRYRINLSVLGPATRGSQGLGRHLPAERVAEFRRALLHYLD------------------FGQKQA 148

  Fly    98 MGKEDLELYADLVSMKANASDLPSLHLPLPAIRPPNLRFWTEAQLNFLTAFLGHSLSDEILQSLY 162
            .|:        |..::...:.||.                  ||           ..:.|||:|.
Human   149 FGR--------LAKLQRERAALPI------------------AQ-----------YGNRILQTLK 176

  Fly   163 ASRVIVYNAALCWDKSVFLPLVILDDCRNKKSNVKIMCIERQAILATYNSQRTANFFGEQLGETV 227
            ..:|:|........||..:|..:|     ......:.|.:.:.|.....::|.......|.|..|
Human   177 EHQVVVVAGDTGCGKSTQVPQYLL-----AAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQV 236

  Fly   228 GIQLPYFSAVSSSTFIIYSTAQYFLRSLTSQ-QFRNISHLVVNDVHLHDPYTDILLSEIRMALSS 291
            |.|:.:.|..|::|.|::.|....||.:..: .......|:|::||....:.|.||..::..|.:
Human   237 GYQIRFESTRSAATKIVFLTVGLLLRQIQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLPT 301

  Fly   292 HQNLRVVLLSQMGNPKKFTDFF---------GEGLQLNMIKQP-EVAPRVSYLNELHSCIALAGI 346
            ..:|:|:|:|...|...|:.:|         |....:.::.|| |..|..|...:|
Human   302 RPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKL--------- 357

  Fly   347 HKGPDIYKEIPEAFRANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTA 411
              .|..:..:.|:.....|..|:.|..:...|.....|.|                      :.|
Human   358 --DPRPFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVL----------------------EAA 398

  Fly   412 VHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVKSAKPD 476
            ..:||...:              ::| |...:|:|:|
Human   399 QTYASHTQR--------------WVV-LPLHSALSVA---------------------------- 420

  Fly   477 FVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQECSIFLLY 541
              |.|.:.|:          :|    ||                           :::|
Human   421 --DQDKVFDV----------AP----PG---------------------------VRKC------ 436

  Fly   542 DNMRNDYLQALVNASDETVKVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWV 606
                                 :|:|:|.|:.......::.:|:.......||..:.....:..|:
Human   437 ---------------------ILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWI 480

  Fly   607 AKDALLRRELILQPNKGDV------QCFRLISKEAYEELSETSQPSLQTMQLDKICLAVKLLS-- 663
            ::.:..:|       ||..      .||||.::..|:..:....|.::.:.||.:.|.:|.:|
Human   481 SQASAEQR-------KGRAGRTGPGVCFRLYAESDYDAFAPYPVPEIRRVALDSLVLQMKSMSVG 538

  Fly   664 -PNTIISEYLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFGI 727
             |.|.      ..|.|||..::..|:.:|:....||.:|.:|.:|..|..:||...:|:|||.|.
Human   539 DPRTF------PFIEPPPPASLETAILYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGS 597

  Fly   728 LLRCLDPILTIVSSLSTADPL---------------------GIPFTEDIDNLWDRFTIYIQ--- 768
            :...::|:|||.::||...|.                     |.|||     |::.|..::|
Human   598 MFSLVEPVLTIAAALSVQSPFTRSAQSSPECAAARRPLESDQGDPFT-----LFNVFNAWVQVKS 657

  Fly   769 ----NS--------IKKERTYLSDN---QF----SDHFI------------FVRLYKEWQNR-MH 801
                ||        |::.|.|...|   ||    .||.:            :.||.:..:.| :|
Human   658 ERSRNSRKWCRRRGIEEHRLYEMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRALH 722

  Fly   802 -----------NRTPPLYLKDEYE--------------------------FMLNGLMEQLTSIRS 829
                       .|...|.|::|.:                          |.|...:.||.:..|
Human   723 QLKRQHEEGAGRRRKVLRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLAQLQAAAS 787

  Fly   830 EIVSSLRAANLIHSRGKLSMNNLNQMSCNWHMVKAALTGGMYPNIYAVDTRKSSLK--------S 886
            .      |.:|  ||.:|:            ::|..|..|:||.:...|...||.|        .
Human   788 S------AQDL--SREQLA------------LLKLVLGRGLYPQLAVPDAFNSSRKDSDQIFHTQ 832

  Fly   887 AFSGNVSMHPNTVL--------------------RDFLEPLNISAQ--SFRTPWIVCNRQKSHIV 929
            |..|.| :||..|.                    ||..:.::...|  ||.:   :....|.::|
Human   833 AKQGAV-LHPTCVFAGSPEVLHAQELEASNCDGSRDDKDKMSSKHQLLSFVS---LLETNKPYLV 893

  Fly   930 YATLVVPL-AVAMFSGHPRIRLSPICDSEMSLTDRN---VNVFIDEWIWMVMSKA-------TAE 983
            ....:..| ::.:||              .|| |.|   ..:..|.|:.:.::.:       .|.
Human   894 NCVRIPALQSLLLFS--------------RSL-DTNGDCSRLVADGWLELQLADSESAIRLLAAS 943

  Fly   984 MVMRTRYYFF---KMYHDLLKHCSELDMWRRDCEPVSQYTVLT-------DTLSKI--------- 1029
            :.:|.|:...   ::.|...:...|    ..:..|||...|.|       .|.|||
Human   944 LRLRARWESALDRQLAHQAQQQLEE----EEEDTPVSPKEVATLSKELLQFTASKIPYSLRRLTG 1004

  Fly  1030 FESEDGFVGFFKPPPITFLPTPQLPSLY 1057
            .|.::.:||     |.|...||.||.|:
Human  1005 LEVQNMYVG-----PQTIPATPHLPGLF 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	3/31 (10%)
		ANK	407..>460	CDD:238125	8/52 (15%)
		Ank_2	413..>460	CDD:289560	7/46 (15%)
		HrpA	<484..973	CDD:224557	120/624 (19%)
		HA2	694..763	CDD:214852	25/89 (28%)
		OB_NTP_bind	823..945	CDD:285018	33/152 (22%)
DHX34	NP_055496.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..94		4/18 (22%)
		HrpA	154..>686	CDD:224557	137/729 (19%)
		DEXDc	179..314	CDD:238005	33/139 (24%)
		DEAH box	279..282		0/2 (0%)
		HELICc	410..496	CDD:197757	23/191 (12%)
		HA2	565..645	CDD:214852	24/84 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	724..766		4/41 (10%)
		OB_NTP_bind	<791..911	CDD:285018	29/151 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810