DRSC/TRiP Functional Genomics Resources

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Protein Alignment bgcn and DHX34

DIOPT Version :10

Sequence 1:NP_523832.2 Gene:bgcn / 47873 FlyBaseID:FBgn0004581 Length:1215 Species:Drosophila melanogaster
Sequence 2:NP_055496.2 Gene:DHX34 / 9704 HGNCID:16719 Length:1143 Species:Homo sapiens


Alignment Length:1263 Identity:238/1263 - (18%)
Similarity:410/1263 - (32%) Gaps:482/1263 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IIQDKYIPQQLLYFLAGRRCCQQFPCTF---------RTSEHE------------AFANNARSLG 47
            :::|.:..:: .|...|...||:|...|         :||..|            |.|:..|:..
Human    38 LLEDAFFREE-DYIRQGSEECQKFWTFFERLQRFQNLKTSRKEEKDPGQPKHSIPALADLPRTYD 101

  Fly    48 LRSQV-VHVNGNSC--------------VKVYKQACRHYLEEPKTLVLSSGATLNMFTLLSRKSL 97
            .|.:: :.|.|.:.              |..:::|..|||:                  ..:|..
Human   102 PRYRINLSVLGPATRGSQGLGRHLPAERVAEFRRALLHYLD------------------FGQKQA 148

  Fly    98 MGKEDLELYADLVSMKANASDLPSLHLPLPAIRPPNLRFWTEAQLNFLTAFLGHSLSDEILQSLY 162
            .|:        |..::...:.||.                  ||           ..:.|||:|.
Human   149 FGR--------LAKLQRERAALPI------------------AQ-----------YGNRILQTLK 176

  Fly   163 ASRVIVYNAALCWDKSVFLPLVILDDCRNKKSNVKIMCIERQAILATYNSQRTANFFGEQLGETV 227
            ..:|:|........||..:|..:|     ......:.|.:.:.|.....::|.......|.|..|
Human   177 EHQVVVVAGDTGCGKSTQVPQYLL-----AAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQV 236

  Fly   228 GIQLPYFSAVSSSTFIIYSTAQYFLRSLTSQ-QFRNISHLVVNDVHLHDPYTDILLSEIRMALSS 291
            |.|:.:.|..|::|.|::.|....||.:..: .......|:|::||....:.|.||..::..|.:
Human   237 GYQIRFESTRSAATKIVFLTVGLLLRQIQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLPT 301

  Fly   292 HQNLRVVLLSQMGNPKKFTDFF---------GEGLQLNMIKQP-EVAPRVSYLNELHSCIALAGI 346
            ..:|:|:|:|...|...|:.:|         |....:.::.|| |..|..|...:|         
Human   302 RPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKL--------- 357

  Fly   347 HKGPDIYKEIPEAFRANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTA 411
              .|..:..:.|:.....|..|:.|..:...|.....|.|                      :.|
Human   358 --DPRPFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVL----------------------EAA 398

  Fly   412 VHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVKSAKPD 476
            ..:||...:              ::| |...:|:|:|                            
Human   399 QTYASHTQR--------------WVV-LPLHSALSVA---------------------------- 420

  Fly   477 FVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQECSIFLLY 541
              |.|.:.|:          :|    ||                           :::|      
Human   421 --DQDKVFDV----------AP----PG---------------------------VRKC------ 436

  Fly   542 DNMRNDYLQALVNASDETVKVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWV 606
                                 :|:|:|.|:.......::.:|:.......||..:.....:..|:
Human   437 ---------------------ILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWI 480

  Fly   607 AKDALLRRELILQPNKGDV------QCFRLISKEAYEELSETSQPSLQTMQLDKICLAVKLLS-- 663
            ::.:..:|       ||..      .||||.::..|:..:....|.::.:.||.:.|.:|.:|  
Human   481 SQASAEQR-------KGRAGRTGPGVCFRLYAESDYDAFAPYPVPEIRRVALDSLVLQMKSMSVG 538

  Fly   664 -PNTIISEYLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFGI 727
             |.|.      ..|.|||..::..|:.:|:....||.:|.:|.:|..|..:||...:|:|||.|.
Human   539 DPRTF------PFIEPPPPASLETAILYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGS 597

  Fly   728 LLRCLDPILTIVSSLSTADPL---------------------GIPFTEDIDNLWDRFTIYIQ--- 768
            :...::|:|||.::||...|.                     |.|||     |::.|..::|   
Human   598 MFSLVEPVLTIAAALSVQSPFTRSAQSSPECAAARRPLESDQGDPFT-----LFNVFNAWVQVKS 657

  Fly   769 ----NS--------IKKERTYLSDN---QF----SDHFI------------FVRLYKEWQNR-MH 801
                ||        |::.|.|...|   ||    .||.:            :.||.:..:.| :|
Human   658 ERSRNSRKWCRRRGIEEHRLYEMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRALH 722

  Fly   802 -----------NRTPPLYLKDEYE--------------------------FMLNGLMEQLTSIRS 829
                       .|...|.|::|.:                          |.|...:.||.:..|
Human   723 QLKRQHEEGAGRRRKVLRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLAQLQAAAS 787

  Fly   830 EIVSSLRAANLIHSRGKLSMNNLNQMSCNWHMVKAALTGGMYPNIYAVDTRKSSLK--------S 886
            .      |.:|  ||.:|:            ::|..|..|:||.:...|...||.|        .
Human   788 S------AQDL--SREQLA------------LLKLVLGRGLYPQLAVPDAFNSSRKDSDQIFHTQ 832

  Fly   887 AFSGNVSMHPNTVL--------------------RDFLEPLNISAQ--SFRTPWIVCNRQKSHIV 929
            |..|.| :||..|.                    ||..:.::...|  ||.:   :....|.::|
Human   833 AKQGAV-LHPTCVFAGSPEVLHAQELEASNCDGSRDDKDKMSSKHQLLSFVS---LLETNKPYLV 893

  Fly   930 YATLVVPL-AVAMFSGHPRIRLSPICDSEMSLTDRN---VNVFIDEWIWMVMSKA-------TAE 983
            ....:..| ::.:||              .|| |.|   ..:..|.|:.:.::.:       .|.
Human   894 NCVRIPALQSLLLFS--------------RSL-DTNGDCSRLVADGWLELQLADSESAIRLLAAS 943

  Fly   984 MVMRTRYYFF---KMYHDLLKHCSELDMWRRDCEPVSQYTVLT-------DTLSKI--------- 1029
            :.:|.|:...   ::.|...:...|    ..:..|||...|.|       .|.|||         
Human   944 LRLRARWESALDRQLAHQAQQQLEE----EEEDTPVSPKEVATLSKELLQFTASKIPYSLRRLTG 1004

  Fly  1030 FESEDGFVGFFKPPPITFLPTPQLPSLY 1057
            .|.::.:||     |.|...||.||.|:
Human  1005 LEVQNMYVG-----PQTIPATPHLPGLF 1027

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bgcnNP_523832.2 DEAD-like_helicase_N 155..314 CDD:475120 40/168 (24%)
ANKYR <398..>460 CDD:440430 8/61 (13%)
ANK repeat 406..438 CDD:293786 3/31 (10%)
P-loop containing Nucleoside Triphosphate Hydrolases 465..>594 CDD:476819 13/128 (10%)
HA2 687..789 CDD:461295 39/156 (25%)
OB_NTP_bind 862..945 CDD:400182 25/113 (22%)
DHX34NP_055496.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 75..94 4/18 (22%)
HrpA 160..>624 CDD:441249 124/656 (19%)
DEAH box 279..282 0/2 (0%)
Negatively regulates interaction with UPF1. /evidence=ECO:0000269|PubMed:26841701 701..955 52/292 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 724..766 4/41 (10%)
OB_NTP_bind 800..911 CDD:400182 25/128 (20%)
Required for phosphorylation of UPF1. Not required for interaction with UPF1. /evidence=ECO:0000269|PubMed:26841701 810..1143 51/246 (21%)
Required for the interaction with SMG1 and subsequent phosphorylation of UPF1. /evidence=ECO:0000269|PubMed:26841701 957..1143 21/80 (26%)
Blue background indicates that the domain is not in the aligned region.

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