Protein Alignment bgcn and DHX57

DIOPT Version :10

• Sequence 1: NP_523832.2
• Gene: bgcn / 47873
• FlyBaseID: FBgn0004581
• Length: 1215
• Species: Drosophila melanogaster
• Sequence 2: NP_945314.1
• Gene: DHX57 / 90957
• HGNCID: 20086
• Length: 1386
• Species: Homo sapiens
• Alignment Length: 1033
• Identity: 225/1033 - (21%)
• Similarity: 400/1033 - (38%)
• Gaps: 239/1033 - (23%)

  Fly    53 VHVNGNSCVKVYKQACRHYLEEPKTLVLSSGATLNMFTLLSRKSLMGKEDLELYADLVSMKANAS 117
            |.|...|.|.:.|:..:.|..:.|::...:|.....|.:        |:....:..::..:.:
Human   489 VIVENESYVNLKKKISKRYDWQAKSVHAENGKICKQFRM--------KQASRQFQSILQERQS-- 543

  Fly   118 DLPSLHLPLPAIRPPNLRFWTEAQLNFLTAFLGHSLSDEILQSLYASRVIVYNAALCWDKSVFLP 182
                    |||        |.|              .:.||..|...:|:|.:......|:..:|
Human   544 --------LPA--------WEE--------------RETILNLLRKHQVVVISGMTGCGKTTQIP 578

  Fly   183 LVILDDCRN----KKSNVKIMCIERQAILATYNSQRTANFFGEQLGETVGIQLPYFSAVSSSTFI 243
            ..||||..|    |.:|  |:|.:.:.|.|...::|.|....|::|.|||.|:...|..||:|.:
Human   579 QFILDDSLNGPPEKVAN--IICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESVKSSATRL 641

  Fly   244 IYSTAQYFLRSLTSQ-QFRNISHLVVNDVHLHDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPK 307
            :|.|....||.|... ..:.:||::|::||.....:|.||..::..:|....|:|:|:|...|.:
Human   642 LYCTTGVLLRRLEGDTALQGVSHIIVDEVHERTEESDFLLLVLKDIVSQRPGLQVILMSATLNAE 706

  Fly   308 KFTDFFGEGLQLNMIKQPEVAPRVSYLNE--LHSCIALAG---------IHKGPDIYKEIPEAFR 361
            .|:|:|      |......:..|...:::  |...||:..         :.....|.||..:| |
Human   707 LFSDYF------NSCPVITIPGRTFPVDQFFLEDAIAVTRYVLQDGSPYMRSMKQISKEKLKA-R 764

  Fly   362 ANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFAS--ELNKANHL 424
            .|....|::::.|:....|....:::..:.....|...:..|:....|:.:...|  :..|.|
Human   765 RNRTAFEEVEEDLRLSLHLQDQDSVKDAVPDQQLDFKQLLARYKGVSKSVIKTMSIMDFEKVN-- 827

  Fly   425 RLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYL 489
             |.|......:|||             |.|
Human   828 -LELIEALLEWIVD-------------GKH----------------------------------- 843

  Fly   490 LRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQ--ECSIFLLYDNMRNDYLQAL 552
                      .|.||.||:.||....|..|...:.|:.|..:.:  .|.|..|:.::.::..||:
Human   844 ----------SYPPGAILVFLPGLAEIKMLYEQLQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAV 898

  Fly   553 -VNASDETVKVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRREL 616
             |.......|::::|:|.|:........|.||:.......||.:  .|.:..|    |..:.:..
Human   899 FVKPPAGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDAS--KGMESLE----DTFVSQAN 957

  Fly   617 ILQPNKGDV------QCFRLISKEAY-EELSETSQPSLQTMQLDKICLAVKLL---SPNTIISEY 671
            .|| .||..      .||.|.:...| .:|.:...|.:|.:.|:::||.:|:|   |.:.:.|.:
Human   958 ALQ-RKGRAGRVASGVCFHLFTSHHYNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSAHNLQSVF 1021

  Fly   672 LGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPIL 736
            ..: |.||...::..:...|:.:..|...|.:|.||..|..:||..::|::::||.:.|||||.|
Human  1022 SRL-IEPPHTDSLRASKIRLRDLGALTPDERLTPLGYHLASLPVDVRIGKLMLFGSIFRCLDPAL 1085

  Fly   737 TIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKKERTYLSDNQF----SDHFIFVRLYKEWQ 797
            ||.:||:...|...|        ||          |||.......:|    ||:...::.||.||
Human  1086 TIAASLAFKSPFVSP--------WD----------KKEEANQKKLEFAFANSDYLALLQAYKGWQ 1132

  Fly   798 NRMHNRTPPLYLKDEYEFMLNGLMEQLTSIR---SEIVS-------SLRAANL----------IH 842
            ..........|......|:...:::::.|::   :|::|       .|||..:          :.
Human  1133 LSTKEGVRASYNYCRQNFLSGRVLQEMASLKRQFTELLSDIGFAREGLRAREIEKRAQGGDGVLD 1197

  Fly   843 SRGKLSMNNLNQMSCNWHMVKAALTGGMYPNIYAVDTRKSSLKSAFSGNVSMHPNTVLRDFL--- 904
            :.|:.:.:|..    |..::.|.|...:|||:..|.:.:...:...:|.|.|.|.:....|:
Human  1198 ATGEEANSNAE----NPKLISAMLCAALYPNVVQVKSPEGKFQKTSTGAVRMQPKSAELKFVTKN 1258

  Fly   905 --------EPLNISAQSFRTPWIVCNRQ-KSHIVY---ATLVVPLAVAMFSGHPRIRLSPICDSE 957
                    ..:|...:.|.:|:::.:.: |:..|:   .::|....:.:|.|
Human  1259 DGYVHIHPSSVNYQVRHFDSPYLLYHEKIKTSRVFIRDCSMVSVYPLVLFGG------------- 1310

  Fly   958 MSLTDRNVNV------FI----DEWI-WMVMSKATAEMVMRTRYYFFKMYHDLLKHCS 1004
                 ..|||      |:    |.|| ::..|...||:|...|....::..|.:|:.|
Human  1311 -----GQVNVQLQRGEFVVSLDDGWIRFVAASHQVAELVKELRCELDQLLQDKIKNPS 1363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	DEAD-like_helicase_N	155..314	CDD:475120	51/163 (31%)
		ANKYR	<398..>460	CDD:440430	12/63 (19%)
		ANK repeat	406..438	CDD:293786	7/33 (21%)
		P-loop containing Nucleoside Triphosphate Hydrolases	465..>594	CDD:476819	25/131 (19%)
		HA2	687..789	CDD:461295	32/105 (30%)
		OB_NTP_bind	862..945	CDD:400182	18/97 (19%)
DHX57	NP_945314.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..106
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..147
		UBA_DHX57	181..218	CDD:270502
		RWD_DHX57	242..425	CDD:467661
		zf_CCCH_4	305..323	CDD:465719
		HrpA	543..>1170	CDD:441249	174/754 (23%)
		DEVH box	668..671		0/2 (0%)
		OB_NTP_bind	1213..1310	CDD:400182	18/96 (19%)