DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and PRP22

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_010929.3	Gene:	PRP22 / 856732	SGDID:	S000000815	Length:	1145	Species:	Saccharomyces cerevisiae

Alignment Length:	964	Identity:	172/964 - (17%)
Similarity:	314/964 - (32%)	Gaps:	353/964 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 LPLPAIRPPNLRFWTEAQLNFLTAFLGHSLSDEILQSLYASRVIVYNAALCWDKSVFLPLVILDD 188
            ||:.|:|...::...:.|...:....|...:.:|.|.|              |:..|
Yeast   483 LPVYAMRSELIQAVRDNQFLVIVGETGSGKTTQITQYL--------------DEEGF-------- 525

  Fly   189 CRNKKSNV-KIMCIERQAILATYNSQRTANFFGEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFL 252
                 ||. .|.|.:.:.:.|...::|.|...|.::|..||..:.:.......|.|.|.|.....
Yeast   526 -----SNYGMIGCTQPRRVAAVSVAKRVAEEVGCKVGHDVGYTIRFEDVTGPDTRIKYMTDGMLQ 585

  Fly   253 R-SLTSQQFRNISHLVVNDVHLHDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFGEG 316
            | :|...:....|.:::::.|.....||:|.:.::.|......|:|::.|...|..||:::|
Yeast   586 REALLDPEMSKYSVIMLDEAHERTVATDVLFALLKKAAIKRPELKVIVTSATLNSAKFSEYF--- 647

  Fly   317 LQLNMIKQP------EV----APRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRANNPRNEQMD 371
            |...:|..|      ||    .|::.|:.....|:....|::||
Yeast   648 LNCPIINIPGKTFPVEVLYSQTPQMDYIEAALDCVIDIHINEGP--------------------- 691

  Fly   372 KCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPYI 436
                  |::
Yeast   692 ------GDI-------------------------------------------------------- 694

  Fly   437 VDLFQQNAISLAAMNGNHE---CIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTKPEYSP 498
                      |..:.|..|   |.::|                   ||.:       :|..: |.
Yeast   695 ----------LVFLTGQEEIDSCCEIL-------------------YDRV-------KTLGD-SI 722

  Fly   499 GEYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQECSIFLLYDNMRNDYLQALVNASDETVKVV 563
            ||      |:|||.|            ..|...:|. .||           :.....|.   |||
Yeast   723 GE------LLILPVY------------SALPSEIQS-KIF-----------EPTPKGSR---KVV 754

  Fly   564 LATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRRELILQP-------- 620
            .||:|.|:........|.:|......|:|:             |:..:  .:||:.|
Yeast   755 FATNIAETSITIDGIYYVVDPGFAKINIYN-------------ARAGI--EQLIVSPISQAQANQ 804

  Fly   621 ------NKGDVQCFRLISKEA-YEELSETSQPSLQTMQLDKICLAVKLLSPNTIIS-EYLGITIS 677
                  ..|..:|:||.::.| |.|:.|.:.|.:|...|....|.:|.:..|.::. :::    .
Yeast   805 RKGRAGRTGPGKCYRLYTESAFYNEMLENTVPEIQRQNLSHTILMLKAMGINDLLKFDFM----D 865

  Fly   678 PPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSL 742
            |||...:.:|:..|..:..|||...:|.||..:...|:...|.|.|:..:..:|.|.|:||:|.|
Yeast   866 PPPKNLMLNALTELYHLQSLDDEGKLTNLGKEMSLFPMDPTLSRSLLSSVDNQCSDEIVTIISML 930

  Fly   743 STADPLGIPFTEDIDNLWDRFTIYIQNSIKKERTYLSDNQ-------FSDHFIFVRLYKEWQNRM 800
            |            :.|::.|         .|:|...:|::       :.||...:.:|..||...
Yeast   931 S------------VQNVFYR---------PKDRQLEADSKKAKFHHPYGDHLTLLNVYTRWQQAN 974

  Fly   801 HNRTPPLYLKDEYEFMLNGLMEQLTSIRSEIVSSLRAANLIHSRGKLSMNNLNQMSCNW--HMVK 863
            ::..   |.|..:....:  :::...::|:|       ::|..:..|.:     :||:.  .:::
Yeast   975 YSEQ---YCKTNFLHFRH--LKRARDVKSQI-------SMIFKKIGLKL-----ISCHSDPDLIR 1022

  Fly   864 AALTGGMYPNIYAVDTRKSSLKSAFSG-NVSMHPNTVLRDFLEPLNISAQSFRTPWIVCNRQKSH 927
            .....|.:.|....|: :...|:...| .|.:||::.|                    ..::..:
Yeast  1023 KTFVSGFFMNAAKRDS-QVGYKTINGGTEVGIHPSSSL--------------------YGKEYEY 1066

  Fly   928 IVYATLVVPLAVAMFSGHPRIRLSPICDSEMSLTDR----NVNVFIDEWIWMV----MSKATAEM 984
            ::|.::|                         ||.|    .|.....:|:..|    .....||.
Yeast  1067 VMYHSIV-------------------------LTSREYMSQVTSIEPQWLLEVAPHFYKAGDAES 1106

  Fly   985 VMRTRYYFFKMYHDLLKHCSELDMWRRDCEPVSQYTVLTDTLSKIFESEDGFVG 1038
            ..|.:.....:::   |...:.:.||               ||.|.:|.:..:|
Yeast  1107 QSRKKAKIIPLHN---KFAKDQNSWR---------------LSSIRQSRERALG 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	0/31 (0%)
		ANK	407..>460	CDD:238125	4/55 (7%)
		Ank_2	413..>460	CDD:289560	4/49 (8%)
		HrpA	<484..973	CDD:224557	99/518 (19%)
		HA2	694..763	CDD:214852	19/68 (28%)
		OB_NTP_bind	823..945	CDD:285018	17/124 (14%)
PRP22	NP_010929.3	Pnp	1..423	CDD:224106
PRP22	NP_010929.3	HrpA	456..1145	CDD:224557	172/964 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900