DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and NIH

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_172152.1	Gene:	NIH / 837177	AraportID:	AT1G06670	Length:	1576	Species:	Arabidopsis thaliana

Alignment Length:	1025	Identity:	228/1025 - (22%)
Similarity:	408/1025 - (39%)	Gaps:	197/1025 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 SSGATLNMFTL----------LSRKSLMGKEDLELYADLVSMKANASDLPSLHLPLPAIRPPNLR 135
            ::|.:|.::|.          ..:|..|.|.|:|  .::||:.:...            :..:.|
plant   158 TTGTSLGIYTTGNVNSNWKDDFFKKPHMTKHDIE--NNVVSLSSRLK------------KERHFR 208

  Fly   136 FWTEAQLNFLTAFLGHSLSDEILQSLYASRVIVYNAALCWDKSVFLPLVILDDC-RNKKSNVKIM 199
            ...||:.....|    |..|.|:.::.:::|::........|:..:|..:||.. .:||...||:
plant   209 EIFEARSKLPIA----SFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMWHSKKEACKII 269

  Fly   200 CIERQAILATYNSQRTANFFGEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLRSL----TSQQF 260
            |.:.:.|.|...|.|.:...||.:|.|||.::...|.....:.:::.|....||.|    .:...
plant   270 CTQPRRISAISVSDRISWERGETIGRTVGYKVRLQSEGGRESSVVFCTNGILLRVLIGKGVNSSV 334

  Fly   261 RNISHLVVNDVHLHDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFGEGLQLNMIKQP 325
            .:|:|::|:::|..|.|:|.:|..:|..|.|:.:||::|:|...:.::|:::|| |..:..:...
plant   335 PDITHIIVDEIHERDSYSDFMLMILRDLLPSNPHLRLILMSATLDAERFSEYFG-GCPVVRVPGF 398

  Fly   326 EVAPRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRANNP-----------RNEQMDKCLQAYGE 379
            ....|..:|::   .:::....|...:...:...|:..:.           .|::.|..:.....
plant   399 TYPVRTFFLDD---ALSVLNSDKNSHLLSAVKRDFKDEDKVSLDEAIDLAWTNDEFDCLVDLVSS 460

  Fly   380 LGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNA 444
            .|:..|              .||::|.||.|.:...:...:.:.:..||.:|||..:.......|
plant   461 EGSHEA--------------YNYQNSTTGLTPLMVFAGKGRVSDVCKLLSVGADCTLKSKEGITA 511

  Fly   445 ISLAAMNGNHECIDVLNSYS-------------LHGYVVKSAKPDFVDYDLIIDIMYLLRTKPEY 496
            :.||......|...::..::             |..|:. :.||:.||..||:.:|..:.:
plant   512 LELAEKENQFETAQIIREHAGNIQSNSQQAQDLLDKYMA-TIKPEEVDVGLIVKLMKKICS---- 571

  Fly   497 SPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQECSIFLLYDNMRNDYLQALVNASDETV- 560
               :...|.||:.||.:..|.|....:|.........:..|..|:..:..:..:.:.|......
plant   572 ---DSKDGAILVFLPGWEEISKTKEKLLDDRFFAHSAKFIILCLHSRVPAEEQKKVFNRPPRGCR 633

  Fly   561 KVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRRELILQPNKGDV 625
            |:||||:|.||........|.||:.......||..:.....:..||:|....:|    ....|..
plant   634 KIVLATNIAESAVTIDDVVYVIDSGRMKEKSYDPYNDVSTLQSSWVSKANAKQR----AGRAGRC 694

  Fly   626 Q---CFRLISKEAYEELSETSQPSLQTMQLDKICLAVKLLSPNTIISEYLGITISPPPLINVHHA 687
            |   |:.|.||.....|.|...|.:..|.:|::||.||:|.||..::::|...:.||...::.:|
plant   695 QAGICYHLYSKLRAASLPEYRVPEVMRMPVDELCLQVKMLDPNCNVNDFLQKLMDPPVAQSIENA 759

  Fly   688 VQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPF 752
            :..||.|..|...|::|.||.:...:||..::.:|:.|.||:.||||.|.:..:....||..:|.
plant   760 LIILKDIGALTPEEELTELGQKFGQLPVHPRISKMIYFAILVNCLDPALILACAADEKDPFTMPL 824

  Fly   753 TEDIDNLWDRFTIYIQNSIKKERTYLSDNQFSDHFIFVRLYKEWQNRMHNRTPPLYLKDEYEFML 817
            :..     ||..   ..:.|.|...|..:. |||...|..::.|:|...:.....:. .:| |:.
plant   825 SPG-----DRKK---AAAAKHELASLYGDH-SDHLATVAAFQCWKNAKASGQAKEFC-SKY-FIS 878

  Fly   818 NGLMEQLTSIRSEIVSSLRAANLIHSRGKLSMNNLNQMSCNWH---MVKAALTGGMYP------- 872
            ..:|::|..:..::...|....:|.|    |.:|   .|.|.|   :::|.:..|:||
plant   879 QVVMKRLDDLCRKLQGELNRHGVIPS----SSSN---CSLNAHDPGILRAVIAVGLYPMLGRMCP 936

  Fly   873 -----------NIYAVDTRKSSLKSAFSGNVSMHPNTVLRDFLEPLNISAQSFRTPWIVCNRQKS 926
                       .|.....|..||    |.||.|...    .|.|.|.:..:..|..|.|..|.
plant   937 LSKNRTRSVIETIAGAKVRVPSL----SNNVDMSST----KFDEALIVFDEITRGDWGVVIRS-- 991

  Fly   927 HIVYATLVVPLAVAMFS-------------------------------------GHP--RIRLSP 952
                .|::..:.|.:||                                     |.|  :|.|.|
plant   992 ----CTVLPTIPVLLFSREIAVSTTESYDAVKSDDEEDHKVGNVGDAMDIDKEVGRPGEKIMLGP 1052

  Fly   953 ICDSEMSLTDRNVNVFIDEWI-WMVMSKATAEM-VMRTRY---YFFKMYH 997
                     :.:|.|.:|.|: :.|.:...|:| ::|.|.   ..||:.|
plant  1053 ---------ENSVKVVVDRWLPFKVTAFEIAQMYILRERLMASILFKVKH 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	8/31 (26%)
		ANK	407..>460	CDD:238125	12/52 (23%)
		Ank_2	413..>460	CDD:289560	9/46 (20%)
		HrpA	<484..973	CDD:224557	127/552 (23%)
		HA2	694..763	CDD:214852	21/68 (31%)
		OB_NTP_bind	823..945	CDD:285018	32/179 (18%)
NIH	NP_172152.1	R3H_DEXH_helicase	18..76	CDD:100077
		DEXDc	223..401	CDD:214692	46/178 (26%)
		DEXDc	234..378	CDD:238005	40/143 (28%)
		ANK	<441..527	CDD:238125	19/99 (19%)
		Ank_5	461..515	CDD:290568	14/67 (21%)
		ANK repeat	475..505	CDD:293786	7/29 (24%)
		ANK repeat	507..533	CDD:293786	4/25 (16%)
		Helicase_C	563..693	CDD:278689	29/140 (21%)
		HA2	766..851	CDD:214852	28/93 (30%)
		OB_NTP_bind	890..1007	CDD:285018	31/137 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106429
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.670