DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and ABO6

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_680142.2	Gene:	ABO6 / 830371	AraportID:	AT5G04895	Length:	1161	Species:	Arabidopsis thaliana

Alignment Length:	1004	Identity:	239/1004 - (23%)
Similarity:	412/1004 - (41%)	Gaps:	213/1004 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 EHEAFANNARSLGLRSQVVHVNGNSCV--KVYKQACRHYLEE---PKTLVLSSGATLNMFTLL-- 92
            ::|..:|.|:.:||.|::.   |...|  ||.....|..|::   .:.:||.......:..||
plant   123 DYEQISNLAKRMGLYSEIY---GKVVVASKVPLPNYRPDLDDKRPQREVVLPLSLQRRVEGLLQE 184

  Fly    93 ---SRKSLMGKEDLELYADLVSMKANASDLPSLH-------------LPLPAIRPPNL-RFWTEA 140
               |::...||.: |..||....| ...:||..:             |...::|..|: |.|.|:
plant   185 HLDSQQLSSGKAN-ECVADSQPPK-QTEELPDENSDSFLDGSVMEKVLQRRSMRMRNMQRTWQES 247

  Fly   141 -----QLNFLTAFLGHSLSDEILQSLYASRVIVYNAALCWDKSVFLPLVILDD---------CRN 191
                 .|.|..........:.:||::..::|||.:......|:..||..||:.         |
plant   248 PEGRTMLEFRKTLPSFKDKERLLQAIARNQVIVVSGETGCGKTTQLPQYILESEIESGRGAFC-- 310

  Fly   192 KKSNVKIMCIERQAILATYNSQRTANFFGEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLRSLT 256
                 .|:|.:.:.|.|...|:|.:...||.||||||.::........:|.:::.|:...||.|.
plant   311 -----NIICTQPRRISAMAVSERVSAERGEPLGETVGFKVRLEGMRGKNTHLLFCTSGILLRRLL 370

  Fly   257 SQQFRN-ISHLVVNDVHLHDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFGEGLQLN 320
            |.:..| ::|:.|:::|......|.|:..::..|....:||:||:|...|.:.|::::|.
plant   371 SDRNLNGVTHVFVDEIHERGMNEDFLIIVLKELLPRRPDLRLVLMSATLNAELFSNYYGG----- 430

  Fly   321 MIKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRANNPRNEQMDKCLQAYGELGTDAA 385
                   ||.:......|...|    |...|:.:.......:.|    |:|.    ||:..|
plant   431 -------APTIHIPGFTHPVKA----HFLEDVLEITGYKLTSFN----QVDD----YGQEKT--- 473

  Fly   386 LRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAM 450
                 :.....|.|...::.:|  |.|..|  |:|:|.         :.|
plant   474 -----WKTQKQLMPRKRKNQIT--TLVEEA--LSKSNF---------ESY--------------- 505

  Fly   451 NGNHECIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYH 515
              |....|.|:|:          .||.:.::||..::..:..|..       ||.:|:.|..:..
plant   506 --NSRTRDSLSSW----------MPDCIGFNLIEAVLCHICRKER-------PGAVLVFLTGWDD 551

  Fly   516 IVKLNYMILSHCLTGSLQECSIFLLYDNMRNDYLQALVNASDETV-KVVLATDIIESLCLKVPFK 579
            |..|:..|.:|.|.|......:.:.:.:|.....:.:...:...: |:||||::.|:........
plant   552 IRSLSDQIKAHPLLGDPNRVLLLMCHGSMATAEQRLIFERAPPNIRKIVLATNMAEASITINDVV 616

  Fly   580 YQIDTACRLNNVYD---TTSCSGDDRFEWVAKDALLRRELILQPNKGDV---QCFRLISKEAYEE 638
            :.:|........||   .|.|...   .|:::.:..:|    :...|.:   :|:.|..|..|:.
plant   617 FVVDCGKAKETTYDALNNTPCLLP---SWISQASARQR----RGRAGRLFPGECYHLYPKCVYDA 674

  Fly   639 LSETSQPSLQTMQLDKICLAVKLLSPNTIISEYLGITISPPPLINVHHAVQFLKKIDVLDDAEDV 703
            .:|...|.|....|:.:||.:|.|...: |:|:|...:..|..:.|.:|:.|||.|..||:.|::
plant   675 FAEYQLPELLRTPLNSLCLQIKSLQVES-IAEFLSAALQAPESLAVQNAIGFLKMIGALDEKENL 738

  Fly   704 TWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQ 768
            |.||..|..:||..:||:|||.|.:.||.||||||||.||..||..:|        .|:..:.:.
plant   739 TDLGKLLSILPVDPKLGKMLIMGAIFRCFDPILTIVSGLSVRDPFLLP--------QDKKDLALS 795

  Fly   769 NSIKKERTYLSDNQFSDHFIFVRLYKEWQNRMHNRTPPLYLKDEYEFMLNGLMEQLT-----SIR 828
            ..::     .|...:|||...||.::.|::.....:       .|||.....:...|     |:|
plant   796 AKLR-----FSAKDYSDHMALVRAFEGWKDAEREGS-------AYEFCWRNFLSAQTLQAIHSLR 848

  Fly   829 SEIVSSLRAANLIHSRGKLSMNNLNQMSCNWHMVKAALTGGMYPNIYAVDTRKSSL--KSAFSGN 891
            .:....|:.|.|:|.  .|::|  |::|.|..:|:|.:..|::|.|.:|..|::|:  |:...|.
plant   849 KQFNYILKEAGLVHD--DLALN--NKLSHNQSLVRAVICSGLFPGIASVVHRETSMSFKTMDDGQ 909

  Fly   892 VSMHPNTVLRDFLEPLNISAQSFRTPWIVCNRQKSHIVYATLV-----VP----------LAVAM 941
            ||::.|:|        |....:...||:|...:..  |.|.|:     ||          |:..:
plant   910 VSLYANSV--------NSRFPTIPYPWLVFGEKVK--VNAVLIRDSTGVPDSSLILFGGSLSTGV 964

  Fly   942 FSGHPRIRLSPICDSEMSLTDRNVNVFID 970
            ..||            :.:.|..::.|:|
plant   965 QVGH------------LKMLDGYIDFFMD 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	8/31 (26%)
		ANK	407..>460	CDD:238125	10/52 (19%)
		Ank_2	413..>460	CDD:289560	7/46 (15%)
		HrpA	<484..973	CDD:224557	130/516 (25%)
		HA2	694..763	CDD:214852	32/68 (47%)
		OB_NTP_bind	823..945	CDD:285018	36/143 (25%)
ABO6	NP_680142.2	HrpA	238..1007	CDD:224557	212/884 (24%)
		P-loop_NTPase	<247..>291	CDD:304359	8/43 (19%)
		DEXDc	277..419	CDD:238005	41/148 (28%)
		Helicase_C	529..621	CDD:278689	18/98 (18%)
		HA2	728..812	CDD:214852	36/96 (38%)
		OB_NTP_bind	849..960	CDD:285018	32/124 (26%)
		DSRM	1059..1122	CDD:238007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810