DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and dhx33

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_001093527.3	Gene:	dhx33 / 796505	ZFINID:	ZDB-GENE-131127-77	Length:	680	Species:	Danio rerio

Alignment Length:	870	Identity:	168/870 - (19%)
Similarity:	300/870 - (34%)	Gaps:	288/870 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 PLPA--IRPPNLRFWTEAQLNFLTAFLGHSLSDEILQ----SLYASRVIVYNAALCWDKSVFLPL 183
            |.||  .:|.:..|..:.:...|....||:.:....|    .:|.||..|.:.......:||
Zfish     7 PPPAKRFKPGSPFFRLDKKPGMLLPRAGHAAAGVEAQRRHLPIYQSRTQVISQLRQLHSAVF--- 68

  Fly   184 VILDDCRNKKSNVKIMCIE----RQAILATYNSQRTA--NFFGE-------QLGETVGIQLPYFS 235
             |.:....|.:.:.....|    ||.|:|....:|.|  :..|.       |||:.||..:.:..
Zfish    69 -IGETGSGKTTQIPQYLYEAGIGRQGIIAITQPRRVAAISLAGRVAEEKKVQLGKLVGYTVRFED 132

  Fly   236 AVSSSTFIIYSTAQYFLR-SLTSQQFRNISHLVVNDVHLHDPYTDILLSEIRMALSS--HQN--- 294
            ..|..|.:.:.|....|| ::........:.:::::.|....:||:|...::.|...  .||
Zfish   133 VTSPETKLKFMTDGMLLREAIGDPLLLRYTVVILDEAHERTVHTDVLFGVVKAAQRRRLEQNKIP 197

  Fly   295 LRVVLLSQMGNPKKFTDFFG-------EG----LQLNMIKQPEVAPRVSYLNELHSCIALAGIHK 348
            |:||::|...:...|:.:|.       ||    :|:...|||:    ..||.     .||..|.:
Zfish   198 LKVVVMSATMDVDLFSQYFNKSPVLYLEGRQHPIQIYYTKQPQ----SDYLQ-----AALVSIFQ 253

  Fly   349 GPDIYKEIPEAFRANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVH 413
               |::|.|
Zfish   254 ---IHQEAP-------------------------------------------------------- 259

  Fly   414 FASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVKSAKPDFV 478
                   ::|..|:...|         |:...:||     ..|.|:    |.|       .||
Zfish   260 -------SSHDILVFLTG---------QEEIEALA-----RTCRDI----SKH-------LPD-- 290

  Fly   479 DYDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSL---QECSIFLL 540
                                   :.|::.:: |.|                .||   |:..:||
Zfish   291 -----------------------TSGSMTVV-PLY----------------ASLPPAQQMRVFL- 314

  Fly   541 YDNMRNDYLQALVNASDETVKVVLATDIIESLCLKVPFKYQIDT----ACRLNNVYDTTSCSGDD 601
                         .|...:.||:|:|:|.|:.......||.|||    |.|.|         .|.
Zfish   315 -------------PAPKGSRKVILSTNIAETSITISGIKYVIDTGMVKAKRFN---------PDS 357

  Fly   602 RFEWVAKDALLRRELILQPNKGDVQ----CFRLISKEAYEELSETSQPSLQTMQLDKICLAVKLL 662
            ..|.:|...:.:.:...:..:...:    |:||.:::.:|.|:..:.|.:|...|..:.|.:..|
Zfish   358 GLEVLAVQRVSKAQAWQRAGRAGREDAGSCYRLYTEDEFENLANMTVPEIQRCNLASVVLQLLAL 422

  Fly   663 S-PNTIISEYLGITISPPPLINVHHAVQ---FLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRML 723
            . |:.:..::    :|.|...::..||:   .|..:|..||...:|.||.::...|:..:..:.|
Zfish   423 GVPDVLNFDF----VSKPSPESMRTAVEQLCILGAVDRKDDHVSLTPLGKKMACFPLEPRFSKTL 483

  Fly   724 IFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKKERTYLSDNQFSDHFI 788
            :......|.:.||||:|.||....|..|.....:.:          |::|:  ::|..  .||..
Zfish   484 LISPDFSCTEEILTIISLLSVDSVLYNPPARRDEVI----------SVRKK--FISSE--GDHIT 534

  Fly   789 FVRLYKEWQNRMHNRTPPLYLKDEYEFMLN-GLMEQLTSIRSEIVSSLRAANLIHSRGKLSMN-N 851
            .:.:|:.::....|:.   :.::.:....| ||:.::.:...:|.              :.|| .
Zfish   535 LLNIYRAFKKVSGNKD---WCRENFVNSRNMGLVGEVRAQLRDIC--------------IKMNLK 582

  Fly   852 LNQMSCNWHMVKAALTGGMY---------PNIYAVDTRKSSLKSAFSGNVSMHPNTVLRD----- 902
            |....|:...|:..|..|::         .:..|:||.:.         ||:||::||..
Zfish   583 LESSVCDLANVRRCLAHGLFMSAAELQPDGSYVALDTHQP---------VSIHPSSVLFQARPVC 638

  Fly   903 --FLEPLNISAQSFR------TPWI 919
              |.|.|:.|....|      |.|:
Zfish   639 VLFNELLHTSRCYMRDLCLIQTDWL 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	3/31 (10%)
		ANK	407..>460	CDD:238125	8/52 (15%)
		Ank_2	413..>460	CDD:289560	8/46 (17%)
		HrpA	<484..973	CDD:224557	94/475 (20%)
		HA2	694..763	CDD:214852	18/68 (26%)
		OB_NTP_bind	823..945	CDD:285018	24/120 (20%)
dhx33	NP_001093527.3	DEXDc	50..234	CDD:214692	42/187 (22%)
		DEXDc	64..207	CDD:238005	33/146 (23%)
		Helicase_C	264..381	CDD:278689	37/206 (18%)
		HA2	451..536	CDD:214852	24/98 (24%)
		OB_NTP_bind	570..670	CDD:285018	24/117 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900