DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and dhx9

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	XP_002937403.1	Gene:	dhx9 / 733723	XenbaseID:	XB-GENE-967775	Length:	1257	Species:	Xenopus tropicalis

Alignment Length:	864	Identity:	198/864 - (22%)
Similarity:	341/864 - (39%)	Gaps:	215/864 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 DEILQSLYASRVIVYNAALCWDKSVFLPLVILDDC-RN-KKSNVKIMCIERQAILATYNSQRTAN 217
            :||:.:::.|.|::...|....|:..:|..|||:| || :.:...|:..:.:.|.|...::|.|.
Frog   397 EEIMHAVHNSPVVIIRGATGCGKTTQVPQYILDECIRNDRAAQCNIVVTQPRRISAVSVAERVAF 461

  Fly   218 FFGEQLGETVGIQLPYFSAV-SSSTFIIYSTAQYFLRSLTSQQFRNISHLVVNDVHLHDPYTDIL 281
            ..||::|::.|..:.:.|.: .....:::.|....||.|.: ..|.|||::|:::|..|..||.|
Frog   462 ERGEEIGKSCGYSVRFESVLPRPHASMLFCTVGVLLRKLEA-GIRGISHVIVDEIHERDINTDFL 525

  Fly   282 LSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFGEGLQLNMIKQPEVAPRVSYLNE--LHSCIALA 344
            |..:|..:.:..::||:|:|...:...|.::|   ....:|   ||..|...:.|  |..||.:.
Frog   526 LVVLRDVIQAFPDIRVILMSATIDTSMFCEYF---FNCPII---EVFGRTFPVQEYFLEDCIQMT 584

  Fly   345 GIHKGPDIYKEIPEAFRANNPRN-EQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTG 408
                     :.||.      ||: ::.||..:...:..|:..|     ....|..| ..|.|::.
Frog   585 ---------QFIPP------PRDKKKKDKDEEGGDDEETNCNL-----VCGDDYGP-ETRRSMSQ 628

  Fly   409 KTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVKSA 473
            .:......||.:|    ||.:                           |:.||
Frog   629 LSEKETPLELIEA----LLKY---------------------------IETLN------------ 650

  Fly   474 KPDFVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQECSIF 538
                                        .||.:|:.||.:..|..:...:..:...||...|.:.
Frog   651 ----------------------------VPGAVLVFLPGWNLIYAMQKHLEMNPHFGSHSYCILP 687

  Fly   539 LLYDNMRNDYLQALVNASDETVKVVLATDIIESLCLKVPFKYQIDTACRL--------NNV--YD 593
            |.....|::..:......|..:||:|:|:|.|:........|.|| :|:.        ||:  |.
Frog   688 LHSQIPRDEQRKVFDPVPDGIIKVILSTNIAETSITINDVVYVID-SCKQKVKLFTSHNNMTNYA 751

  Fly   594 TTSCSGDDRFEWVAKDALLRRELILQPNKGDVQ---CFRLISKEAYEELSETSQPSLQTMQLDKI 655
            |.         |.:|..|.:|    :...|.|:   ||.|.|:..:|.|.....|.:....|.::
Frog   752 TV---------WASKTNLEQR----KGRAGRVRPGFCFHLCSRARFERLETHLTPEIFRTPLHEV 803

  Fly   656 CLAVKLLSPNTIISEYLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLG 720
            .|::|||.... |.::|...|.||||..|..|...|:::|.||..:::|.||..|..:|:..:||
Frog   804 ALSIKLLRLGG-IGQFLSKAIEPPPLDAVIEAEHTLRELDALDSNDELTPLGRILAKLPIEPRLG 867

  Fly   721 RMLIFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKKERTYLSDNQFSD 785
            :|:|.|.:....|.:.||  |.:|..|  .||..:     .|...|:..:       .:.|:|||
Frog   868 KMMIMGCIFYVGDALCTI--SAATCFP--EPFISE-----GRRLGYVHRN-------FAGNRFSD 916

  Fly   786 HFIFVRLYKEWQN-RM-----------HNRTPPLYLKDEYEFMLNGLMEQLTSIRSEIVSSLRAA 838
            |...:.:::.|.: ||           |.|.....|:..:|..:. |.|.|  :.|.........
Frog   917 HVALLSVFQAWDDARMGGEEAETRFCEHKRLNMATLRMTWEAKVQ-LKEIL--VNSGFPEECLMT 978

  Fly   839 NLIHSRGKLSMNNLNQMSCNWHMVKAALTGGMYPNI-YAVDTR-------------KSSLKSAFS 889
            .:.::.|  ..|||:       :|.:.|..|:|||: |..:.|             |||:...||
Frog   979 QVFNNTG--PDNNLD-------VVISLLAFGVYPNVCYHKEKRKILTTEGRNALIHKSSVNCPFS 1034

  Fly   890 GNVSMHPNTVLRDFLEPLNISAQSFRTPWIVCNRQKSHIVYATLVVPLAVAMFSGHPRIRLSPIC 954
            .....:|:        |..:.::..||..|.....       |:|.||.:.:|:
Frog  1035 NQDLKYPS--------PFFVFSEKIRTRAISAKGM-------TMVSPLQLLLFA----------- 1073

  Fly   955 DSEMSLTDRNVNVFIDEWI 973
             |:..::|... :.:|:||
Frog  1074 -SKKVMSDGEF-ILLDDWI 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	5/31 (16%)
		ANK	407..>460	CDD:238125	6/52 (12%)
		Ank_2	413..>460	CDD:289560	6/46 (13%)
		HrpA	<484..973	CDD:224557	123/527 (23%)
		HA2	694..763	CDD:214852	21/68 (31%)
		OB_NTP_bind	823..945	CDD:285018	29/135 (21%)
dhx9	XP_002937403.1	DSRM_DHX9_rpt1	3..71	CDD:380683
		DSRM_DHX9_rpt2	181..255	CDD:380684
		DEXHc_DHX9	333..565	CDD:350730	46/174 (26%)
		HrpA	345..>1054	CDD:224557	186/806 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910