DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and Dhx30

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_001239612.1	Gene:	Dhx30 / 72831	MGIID:	1920081	Length:	1223	Species:	Mus musculus

Alignment Length:	869	Identity:	193/869 - (22%)
Similarity:	321/869 - (36%)	Gaps:	256/869 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 DEILQSLYASRVIVYNAALCWDKSVFLPLVILD----DCRNKKSNVKIMCIERQAILATYNSQRT 215
            |.||.::....|:|.:......|:..:|.::|:    :.|..:.||.|  .:.:.|.|...:||.
Mouse   470 DTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVII--TQPRRISAVSVAQRV 532

  Fly   216 ANFFGEQLGETVGIQLPYFS-AVSSSTFIIYSTAQYFLRSLTSQ-QFRNISHLVVNDVHLHDPYT 278
            ::..|..|...||.|:...| ..:....:::.|....||.|.|. ....:||::|::||..|..|
Mouse   533 SHELGPSLRRNVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNT 597

  Fly   279 DILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFGEGLQLNMIKQPEVAPRVS--YLNELHSCI 341
            |.||..::.....:..||:||:|..|:.::|:.:||   ...:||.|.....|.  ||.::   :
Mouse   598 DFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFG---GCPVIKVPGFMYPVKEHYLEDI---L 656

  Fly   342 ALAGIHKGPDIYKEIPEAFRANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSL 406
            |..|.|:.|                                                   :||.
Mouse   657 AKLGKHQYP---------------------------------------------------HRHR- 669

  Fly   407 TGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVK 471
                  |..||                                    .||.
Mouse   670 ------HHESE------------------------------------DECA-------------- 678

  Fly   472 SAKPDFVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIV-------------KLNYMI 523
                  :|.||:.|::..:..:.|       ||.||..||.:..|.             :..|:|
Mouse   679 ------LDLDLVTDLVLHIDARGE-------PGGILCFLPGWQEIKGVQQRLQEALGMHESKYLI 730

  Fly   524 LS-HCLTGSLQECSIFLLYDNMRNDYLQALVNASDETVKVVLATDIIESLCLKVPFKYQIDTACR 587
            |. |.....:.:.:||          .|..:...    |:||||:|.|:........:.:|:...
Mouse   731 LPVHSNIPMMDQKAIF----------QQPPLGVR----KIVLATNIAETSITVNDIVHVVDSGLH 781

  Fly   588 LNNVYD---TTSCSGDDRFEWVAKDALLRRELILQPNKGDVQ---CFRLISKEAYEELSETSQPS 646
            ....||   ..||.   ...||::..:::|    :...|..|   .:.|..:...|::.....|.
Mouse   782 KEERYDLKTKVSCL---ETVWVSRANVIQR----RGRAGRCQSGFAYHLFPRSRLEKMVPFQVPE 839

  Fly   647 LQTMQLDKICLAVKLLSPNTIISEYLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLM 711
            :....|:.:.|..|:..|.....|:|...:..|.:..|..||..|::|.|||..|.:|.||.||.
Mouse   840 ILRTPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLA 904

  Fly   712 DIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKKERT 776
            .|....:|.:.::...:.|||.|:|.:||.| |.|    ||:..:.|         :..:.|.:.
Mouse   905 HISTDPRLAKAIVLAAIFRCLHPLLVVVSCL-TRD----PFSSSLQN---------RAEVDKVKA 955

  Fly   777 YLSDNQFSDHFIFVRLYKEWQN--RMHNRTP-PLYLKDEYEF-----MLNGLMEQLTSIRSEIVS 833
            .||.:..|||..|||....|:.  |..:||. ..||::...:     .::||::|.:       .
Mouse   956 LLSHDSGSDHLAFVRAVAGWEEVLRWQDRTSRENYLEENLLYAPSLRFIHGLIKQFS-------E 1013

  Fly   834 SLRAANLIHSRGKLSMNNLNQMSCNWH-----MVKAALTGGMYPNIYAVDTRKSSLKSAF----- 888
            ::..|.|:   ||.|...|....||.:     :||..|..|:|||:..|...|.:.:..|
Mouse  1014 NIYEAFLV---GKPSDCTLPSAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSV 1075

  Fly   889 -----SGNVSMHPNTVLRDFLEPLNISAQSFRTPWI-----VCNRQKSHIVYATLVVPLAVAMFS 943
                 |||:.:|.:|:.|:        |...|:.|:     |.:.....:..::.|.||||.:
Mouse  1076 TYRTKSGNILLHKSTINRE--------ATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLL-- 1130

  Fly   944 GHPRIRLSPICDSEMSLTDRNVNV 967
                            |||.:|::
Mouse  1131 ----------------LTDGDVHI 1138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	3/31 (10%)
		ANK	407..>460	CDD:238125	5/52 (10%)
		Ank_2	413..>460	CDD:289560	5/46 (11%)
		HrpA	<484..973	CDD:224557	127/532 (24%)
		HA2	694..763	CDD:214852	25/68 (37%)
		OB_NTP_bind	823..945	CDD:285018	34/141 (24%)
Dhx30	NP_001239612.1	DEXDc	467..646	CDD:214692	49/180 (27%)
		DEXDc	481..622	CDD:238005	39/142 (27%)
		HELICc	715..814	CDD:197757	22/119 (18%)
		HA2	886..969	CDD:214852	31/96 (32%)
		OB_NTP_bind	1009..1131	CDD:285018	34/157 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810