DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and Dhx36

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_082412.2	Gene:	Dhx36 / 72162	MGIID:	1919412	Length:	1001	Species:	Mus musculus

Alignment Length:	930	Identity:	226/930 - (24%)
Similarity:	382/930 - (41%)	Gaps:	177/930 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 HSLSDEILQSLYASRVIVYNAALCWDKSVFLPLVILDDC--RNKKSNVKIMCIERQAILATYNSQ 213
            :.:..|::..:...:|.|.:......|:..:...|||:.  |.|.|..:|:|.:.:.|.|...::
Mouse   203 YGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAE 267

  Fly   214 RTANFFGEQL--GETVGIQLPYFSAV-SSSTFIIYSTAQYFLRSLTS-QQFRNISHLVVNDVHLH 274
            |.|....|..  |.:.|.|:...|.: .....|:|.|....|:.|.| .:..::||:|::::|..
Mouse   268 RVATERAESCGNGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHER 332

  Fly   275 DPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFGEGLQLNMIKQPEVA-PRVSYLNELH 338
            :..:|:|::.|:..|....:|:|:|:|...|.:||:::||   ...||..|... |.|.||.|
Mouse   333 NLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFG---NCPMIHIPGFTFPVVEYLLE-- 392

  Fly   339 SCIALAGIHKGPDIYKEIPEAFRANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYR 403
                        ||.::|.........|::.....:|.:                      || |
Mouse   393 ------------DIIEKIRYVPDQKEHRSQFKRGFMQGH----------------------VN-R 422

  Fly   404 HSLTGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGY 468
            .....|.|::  .|...|             ||.:|..:.:.|         .:|||
Mouse   423 QEKEEKEAIY--KERWPA-------------YIKELRTRYSAS---------TVDVL-------- 455

  Fly   469 VVKSAKPDFVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQ 533
              :....|.||.:||..::       .|...|...|.||:.||.:.:|..|:.:::|..:..|
Mouse   456 --QMMDDDKVDLNLIAALI-------RYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKS-- 509

  Fly   534 ECSIFLLYDNMRNDYLQALVNASDETV----------KVVLATDIIESLCLKVPFKYQIDTACRL 588
              ..||:..      |.:|:...::|.          |:|:||:|.|:........|.||.....
Mouse   510 --DKFLIIP------LHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIK 566

  Fly   589 NNVYDTTSCSGDDRFEWVAKDALLRRELILQPNKGDVQ---CFRLISKEAYEELSETSQPSLQTM 650
            ...:||.:.......|||:|....:|    :...|.||   |:.|.:......|.:...|.:...
Mouse   567 ETHFDTQNNISTMSAEWVSKANAKQR----KGRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRT 627

  Fly   651 QLDKICLAVKLLSPNTIISEYLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPV 715
            .|:::||.:|:|.... |:.:|...:.||....|..:::.|.::..||..|::|.||..|..:||
Mouse   628 PLEELCLQIKILRLGG-IAYFLSRLMDPPSNEAVVLSIKHLMELSALDKQEELTPLGVHLARLPV 691

  Fly   716 SCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKKERTYLSD 780
            ...:|:|::||.|..||||:|||.:|||..||..||..::          .|.::.:||   |:.
Mouse   692 EPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKE----------KIADARRKE---LAK 743

  Fly   781 NQFSDHFIFVRLYKEWQNRMHNRTPPLYLKD---EYEFMLNGLMEQLTSIRSEIVSSLRAANLIH 842
            ...|||...|..::.|:..  .|....|.||   || |:.:..::.|.:::.:....|..|..:.
Mouse   744 ETRSDHLTVVNAFEGWEEA--KRRGFRYEKDYCWEY-FLSSNTLQMLHNMKGQFAEHLLGAGFVS 805

  Fly   843 SRG-KLSMNNLNQMSCNWHMVKAALTGGMYPNIYAV-----DTRKS-SLKSAFSGNVSMHPNTVL 900
            ||. |....|:|  |.|..::||.:..|:||.:..:     ..||. .:.:...|.||:||.:|
Mouse   806 SRSPKDPKANIN--SDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVHTKSDGLVSIHPKSV- 867

  Fly   901 RDFLEPLNISAQSFRTPWIVCN---RQKSHIVY-ATLVVPLAVAMFSGHPRIRLSPICDSEMSLT 961
                   |:....|...|::.:   |..|..:| .|.|.|..:..|.|.  |.:....|.|:
Mouse   868 -------NVEQTDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCLLFFGGD--ISIQKDKDQEI--- 920

  Fly   962 DRNVNVFIDEWIWMVMSKATAEMVMRTRYYFFKMYHDLLKHCSELDMW----RRDCEPVSQYTVL 1022
                 :.:||||.....:..|.:|...|.....:..:.::....:| |    .|||..:|....|
Mouse   921 -----IAVDEWIVFQSPERIAHLVKGLRKELDSLLQEKIESPHPVD-WDDTKSRDCAVLSAILDL 979

  Fly  1023 TDTLSKIF------ESEDGF 1036
            ..|..|..      .|:||:
Mouse   980 IKTQEKATPRNLPPRSQDGY 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	6/31 (19%)
		ANK	407..>460	CDD:238125	9/52 (17%)
		Ank_2	413..>460	CDD:289560	7/46 (15%)
		HrpA	<484..973	CDD:224557	133/515 (26%)
		HA2	694..763	CDD:214852	28/68 (41%)
		OB_NTP_bind	823..945	CDD:285018	33/132 (25%)
Dhx36	NP_082412.2	Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	1..193
		Required for the pre-miR-134 transport. /evidence=ECO:0000250\|UniProtKB:D4A2Z8	1..97
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54
		Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	1..44
		Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	46..98
		DSM (DHX36-specific motif). /evidence=ECO:0000250\|UniProtKB:Q05B79, ECO:0000250\|UniProtKB:Q9H2U1	46..68
		RecA-like domain 1. /evidence=ECO:0000250\|UniProtKB:Q05B79	99..379		46/178 (26%)
		HrpA	188..894	CDD:224557	198/812 (24%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	258..310		12/51 (24%)
		DEAH box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	327..330		0/2 (0%)
		RecA-like domain 2. /evidence=ECO:0000250\|UniProtKB:Q05B79	380..621		68/332 (20%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	491..550		15/68 (22%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	510..521		3/16 (19%)
		WH domain. /evidence=ECO:0000250\|UniProtKB:Q05B79	622..691		19/69 (28%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	631..690		17/59 (29%)
		OB-fold-like subdomains. /evidence=ECO:0000250\|UniProtKB:Q05B79	834..898		16/71 (23%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	842..853		2/10 (20%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	863..893		8/37 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810