DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and Dhx34

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_001272860.1	Gene:	Dhx34 / 71723	MGIID:	1918973	Length:	1145	Species:	Mus musculus

Alignment Length:	964	Identity:	184/964 - (19%)
Similarity:	316/964 - (32%)	Gaps:	342/964 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 MGKEDLELYADL---------VSMKANASDLPSLHLPLPAIRPPNLRFWTEAQLNFL-------- 145
            |.|..:...|||         :::...:.|....|.|...:.|..:..:..|.|::|
Mouse    87 MPKHGIAALADLPLTYDPRYRINLSILSPDTRGRHGPGRGLPPERVSEFRRALLHYLDFQQKQAF 151

  Fly   146 ----------TAFLGHSLSDEILQSLYASRVIVYNAALCWDKSVFLPLVILDDCRNKKSNVKIMC 200
                      .|.......:.|||:|...:|:|........||..:|..:|     ......:.|
Mouse   152 GRLVKLQRERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLL-----AAGFSHVAC 211

  Fly   201 IERQAILATYNSQRTANFFGEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLRSLTSQ-QFRNIS 264
            .:.:.|.....::|.......|.|..||.|:.:.|..|::|.|::.|....||.:..: ......
Mouse   212 TQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQREPSLPQYQ 276

  Fly   265 HLVVNDVHLHDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFF---------GEGLQLN 320
            .|:|::||....:.|.||..::..|....:|:|:|:|...|...|:.:|         |....:.
Mouse   277 VLIVDEVHERHLHNDFLLGVLQRLLPQRPDLKVILMSATINISLFSSYFSHAPVVQVPGRLFPIT 341

  Fly   321 MIKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRANNPRNEQMDKC--LQAYGELGT- 382
            ::.||:.|.:.:..:|          ...|..:..:.||.....|..|:.|..  |....|:.|
Mouse   342 VVYQPQEADQTASKSE----------KLDPRPFLRVLEAIDNKYPPEERGDLLVFLSGMAEITTV 396

  Fly   383 -DAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAIS 446
             |||.   .||            |||.:..|                          |...:|:|
Mouse   397 LDAAQ---AYA------------SLTQRWVV--------------------------LPLHSALS 420

  Fly   447 LAAMNGNHECIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIILP 511
            ::                              |.|.:.|:               :|..:.
Mouse   421 VS------------------------------DQDKVFDV---------------APAGVR---- 436

  Fly   512 TYYHIVKLNYMILSHCLTGSLQECSIFLLYDNMRNDYLQALVNASDETVKVVLATDIIESLCLKV 576
                                                             |.:|:|:|.|:.....
Mouse   437 -------------------------------------------------KCILSTNIAETSVTID 452

  Fly   577 PFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRRELILQPNKGDV------QCFRLISKEA 635
            ..::.:|:.......||..:.....:..|:::.:..:|       ||..      .|:||.::..
Mouse   453 GIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQR-------KGRAGRTGPGVCYRLYAESD 510

  Fly   636 YEELSETSQPSLQTMQLDKICLAVKLLS---PNTIISEYLGITISPPPLINVHHAVQFLKKIDVL 697
            |:..:....|.::.:.||.:.|.:|.:|   |.|.      ..|.|||..:|..|:.:|::...|
Mouse   511 YDAFAPYPVPEIRRVALDALVLQMKSMSVGDPRTF------PFIEPPPPASVETAILYLQEQGAL 569

  Fly   698 DDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPL-------------- 748
            |.:|.:|.:|..|..:||...:|:|||.|.:....:|:|||.::||...|.
Mouse   570 DSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLAEPVLTIAAALSVQSPFTRSAQSNLDCATAR 634

  Fly   749 -------GIPFTEDIDNLWDRFTIYIQ-------NS--------IKKERTYLSDN---QF----S 784
                   |.|||     |::.|..::|       ||        :::.|.|...|   ||    .
Mouse   635 RPLESDQGDPFT-----LFNVFNAWVQVKSERSGNSRKWCRRRGVEEHRLYEMANLRRQFKELLE 694

  Fly   785 DHFI------------FVRLYKEWQNR-MH-----------NRTPPLYLKD-------------- 811
            ||.:            :.||.:..:.| :|           .|...|.|::
Mouse   695 DHGLLSGAQVVAPGDSYSRLQQRRERRALHQLKRQHEEGGGRRRKVLRLQEDGCSSDEEDREGST 759

  Fly   812 ----------EYEFMLNGLMEQLTSIRSEIVSSLRAANLIHSRGKLSMNNLNQMSCNWHMVKAAL 866
                      :.:|.|...:|||.:..|.      |.:|  :|.:|:            ::|..|
Mouse   760 SQRADSVDIQDVKFKLRHNLEQLQAAASS------AQDL--TRDQLA------------LLKLVL 804

  Fly   867 TGGMYPNIYAVDTRKSSLK--------SAFSGNVSMHPNTVLRDFLEPLNISAQ 912
            ..|:||.:...|...|..|        .|..|.| :||..|..:..|.|:...|
Mouse   805 GRGLYPQLAVPDAFNSGRKDSDQIFHTQAKQGTV-LHPTCVFANSPEVLHTQGQ 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	3/31 (10%)
		ANK	407..>460	CDD:238125	5/52 (10%)
		Ank_2	413..>460	CDD:289560	3/46 (7%)
		HrpA	<484..973	CDD:224557	103/537 (19%)
		HA2	694..763	CDD:214852	25/89 (28%)
		OB_NTP_bind	823..945	CDD:285018	24/98 (24%)
Dhx34	NP_001272860.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		HrpA	153..>688	CDD:224557	134/706 (19%)
		DEAH box	281..284		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..764		3/37 (8%)
		OB_NTP_bind	800..910	CDD:369483	17/59 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1091..1114
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810