DRSC/TRiP Functional Genomics Resources

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Protein Alignment bgcn and YTHDC2

DIOPT Version :9

Sequence 1:NP_523832.2 Gene:bgcn / 47873 FlyBaseID:FBgn0004581 Length:1215 Species:Drosophila melanogaster
Sequence 2:XP_011541883.1 Gene:YTHDC2 / 64848 HGNCID:24721 Length:1439 Species:Homo sapiens


Alignment Length:1179 Identity:292/1179 - (24%)
Similarity:494/1179 - (41%) Gaps:205/1179 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 QFPCTFRTSEHEAFANNARSLGLRSQVVHVNGNSCVKVYKQACRHYLEEPKTLVLSSGATLNMFT 90
            :||.:..::|.......::||||.|:......|..:.|.|:..........|..|:......:.:
Human    65 EFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKKDGSETAHAMMTCNLTHNTKHAVRS 129

  Fly    91 LLSRKSLMGKEDLELY-----ADLVSMKANASDLPS----LHLPLPAIRPPNLRFWTEAQLNFLT 146
            |:.|..:..||..||.     .::.:::|...::..    |:..:|.|  |..|..:|.. :|..
Human   130 LIQRFPVTNKERTELLPKTERGNVFAVEAENREMSKTSGRLNNGIPQI--PVKRGESEFD-SFRQ 191

  Fly   147 AFLGHSLSDEILQSLYASRVIVYNAALCWDKSVFLPLVILDDCRNKKSNVKIMCIERQAILATYN 211
            :.......:||::.:..::|::........|:..:|..:||||.......:|.|.:.:.:.|...
Human   192 SLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQPRRLAAIAV 256

  Fly   212 SQRTANFFGEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLRSLTS--QQFRNISHLVVNDVHLH 274
            ::|.|....|::|:|:|.|:...|.||..|.:.:.|....||:|.:  .....::|::|::||..
Human   257 AERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHER 321

  Fly   275 DPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFG------------------------- 314
            |.::|.||:::|..|..|..|:::|.|...:...|..:||                         
Human   322 DRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRT 386

  Fly   315 ------EGLQLNMIKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRANNPRN------ 367
                  |.|:....||.|...:.: |.|.:|.        ..:.:|  ||:.|.....|      
Human   387 TGYTNKEMLKYKKEKQQEEKQQTT-LTEWYSA--------QENSFK--PESQRQRTVLNVTDEYD 440

  Fly   368 --------------------------EQMDKCL-QAYGELGTDAALRPFLYAVNYDLAPVNYRHS 405
                                      ::||.|| ..:.....||..:.| :.:..:...|:||||
Human   441 LLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDIDAFAQVF-HLILTENVSVDYRHS 504

  Fly   406 LTGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSL----- 465
            .|..||:..|:....|:.:..|:.|||:.:........|:..|...|..|.:|:|.|||.     
Human   505 ETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSATLEFG 569

  Fly   466 ---HGYVVKSAKPDF-------------------VDYDLIIDIMYLLRTKPEYSPGEYSPGNILI 508
               ...:|::...|.                   ||.|||:.::|.:....:       .|.:||
Human   570 NLDESSLVQTNGSDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCD-------AGAVLI 627

  Fly   509 ILPTYYHIVKLNYMIL--SHCLTGSLQECSIFLLYDNMR-NDYLQALVNASDETVKVVLATDIIE 570
            .||.|..||.|...||  ......|.....:|:|:.||: :|..:.|.|......|::|:|:|.|
Human   628 FLPGYDEIVGLRDRILFDDKRFADSTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAE 692

  Fly   571 SLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRRELILQPNKGDVQ------CFR 629
            :........:.||:.......:|..:.....:..|::|.:.::|       ||...      |||
Human   693 TSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQR-------KGRAGRCRPGICFR 750

  Fly   630 LISKEAYEELSETSQPSLQTMQLDKICLAVKLLSP-NTIISEYLGITISPPPLINVHHAVQFLKK 693
            |.|:..::.:.|...|.|..|.|.::||..|||:| |..|:::|.....|||.:.|.:|||.||.
Human   751 LFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLAPVNCPIADFLMKAPEPPPALIVRNAVQMLKT 815

  Fly   694 IDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDN 758
            ||.:|..||:|.||..|.|:||...||:|::..::|:||||||||..:|:..||..:|       
Human   816 IDAMDTWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLP------- 873

  Fly   759 LWDRFTIYIQNSIKKE----RTYLSDNQFSDHFIFVRLYKEWQNRMHNRTPPLYLKDEYEFMLNG 819
                    .|.|.|:.    |...:...||||...:|.::.||....:.....:.  |..|:...
Human   874 --------TQASQKRAAMLCRKRFTAGAFSDHMALLRAFQAWQKARSDGWERAFC--EKNFLSQA 928

  Fly   820 LMEQLTSIRSEIVSSLRAANLIHSRGKLSMNNLNQMSCNWHMVKAALTGGMYPNIYAVDTRKSSL 884
            .||.:..:|::::..|||:..:.:||...:.::|..|.||.:|||||..|||||:..||.....|
Human   929 TMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENLVL 993

  Fly   885 KSAFSGNVSMHPNTVLRD----FLEPLNISAQSFR---TPWIVCNRQ-KSH----IVYATLVVPL 937
            .......|..||.:||..    .:.|.|..|.:.:   |.|::.:.. ::|    |...:.|.|:
Human   994 TGPKEKKVRFHPASVLSQPQYKKIPPANGQAAAIKALPTDWLIYDEMTRAHRIANIRCCSAVTPV 1058

  Fly   938 AVAMFSGHPRIRLSPI---------------CDSEM-SLTDRNVNVF-IDEWIWMVMSKATAEMV 985
            .:.:|.|..|:..:.:               .|||| ..|..|:... :|||:...:....|.::
Human  1059 TILVFCGPARLASNALQEPSSFRVDGIPNDSSDSEMEDKTTANLAALKLDEWLHFTLEPEAASLL 1123

  Fly   986 MRTRYYFFKMYHDLLKHCSELDMWRRDCEPVSQYTVLT-DTLSKIFESEDGFVGFFKPPPITFLP 1049
            ::.|    :.:|.|.     |...|...:|.||....| ..:..:..:|:...|..:|..|...|
Human  1124 LQLR----QKWHSLF-----LRRMRAPSKPWSQVDEATIRAIIAVLSTEEQSAGLQQPSGIGQRP 1179

  Fly  1050 TP----QLP 1054
            .|    :||
Human  1180 RPMSSEELP 1188

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bgcnNP_523832.2 ANK repeat 406..438 CDD:293786 9/31 (29%)
ANK 407..>460 CDD:238125 14/52 (27%)
Ank_2 413..>460 CDD:289560 11/46 (24%)
HrpA <484..973 CDD:224557 152/531 (29%)
HA2 694..763 CDD:214852 28/68 (41%)
OB_NTP_bind 823..945 CDD:285018 38/133 (29%)
YTHDC2XP_011541883.1 R3H_DEXH_helicase 46..104 CDD:100077 10/38 (26%)
HrpA 189..>1016 CDD:224557 227/869 (26%)
DEXHc_YTHDC2 193..368 CDD:350745 44/174 (25%)
ANK repeat 505..537 CDD:293786 9/31 (29%)
ANK repeat 539..564 CDD:293786 8/24 (33%)
OB_NTP_bind 971..1066 CDD:369483 28/94 (30%)
YTH 1288..1404 CDD:367840
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S4903
OMA 1 1.010 - - QHG48010
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_106429
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
65.630

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