DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and Dhx38

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_848467.1	Gene:	Dhx38 / 64340	MGIID:	1927617	Length:	1228	Species:	Mus musculus

Alignment Length:	836	Identity:	158/836 - (18%)
Similarity:	280/836 - (33%)	Gaps:	276/836 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 GKEDL---ELYADLVSMKANASD----LPSL-----HLPLPAIRPPNLRFWTEAQLNFLTAFLGH 151
            ||.|.   :.:||.:..|:.||.    ..|:     :||:.|::...|....:..:..:....|.
Mouse   496 GKVDYRTEQKFADHMKEKSEASSEFAKKKSILEQRQYLPIFAVQQELLTIIRDNSIVIVVGETGS 560

  Fly   152 SLSDEILQSLYASRVIVYNAALCWDKSVFLPLVILDDCRNKKSNVKIMCIERQAILATYNSQRTA 216
            ..:.::.|.|:......|.                          .|.|.:.:.:.|...::|.:
Mouse   561 GKTTQLTQYLHEDGYTDYG--------------------------MIGCTQPRRVAAMSVAKRVS 599

  Fly   217 NFFGEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLR-SLTSQQFRNISHLVVNDVHLHDPYTDI 280
            ...|..|||.||..:.:....|.:|.|.|.|....|| ||......:.|.:::::.|.....||:
Mouse   600 EEMGGNLGEEVGYAIRFEDCTSENTLIKYMTDGILLRESLREADLDHYSAVIMDEAHERSLNTDV 664

  Fly   281 LLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFGEGLQLNMIKQPEVAPRVSYLNELHSCIALAG 345
            |...:|..::...:|::::.|...:.:||..|||.
Mouse   665 LFGLLREVVARRSDLKLIVTSATMDAEKFAAFFGN------------------------------ 699

  Fly   346 IHKGPDIYKEIPEAFRANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKT 410
                                                                .|:.:   :.|:|
Mouse   700 ----------------------------------------------------VPIFH---IPGRT 709

  Fly   411 AVHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVKSAKP 475
            ..                                            :|:|.|        |:.:.
Mouse   710 FP--------------------------------------------VDILFS--------KTPQE 722

  Fly   476 DFVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQE------ 534
            |:|:..:...:...|         ..:||:|||.:|....|...:..|:.|     |:|
Mouse   723 DYVEAAVKQSLQVHL---------SGAPGDILIFMPGQEDIEVTSDQIVEH-----LEELENAPA 773

  Fly   535 CSIFLLYDNMRNDYLQALV--NASDETVKVVLATDIIESLCLKVPFKYQIDTA-CRLN------- 589
            .::..:|..:.:| |||.:  .|.|...|.::||:|.|:........:.||:. |:|.
Mouse   774 LAVLPIYSQLPSD-LQAKIFQKAPDGVRKCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIG 837

  Fly   590 ----NVYDTTSCSGDDRFEWVAKDALLRRELILQPNKGDVQCFRLISKEAYE-ELSETSQPSLQT 649
                .:|..:..:.:.|.....:             .|..|||||.::.||: ||..|:.|.:|.
Mouse   838 MDALQIYPISQANANQRSGRAGR-------------TGPGQCFRLYTQSAYKNELLTTTVPEIQR 889

  Fly   650 MQLDKICLAVKLLSPNTIISEYLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIP 714
            ..|..:.|.:|.|....::..:.   :.|||..|:.:::..|..:..||:...:|..|..:::.|
Mouse   890 TNLANVVLLLKSLGVQDLLQFHF---MDPPPEDNMLNSMYQLWILGALDNTGGLTSTGRLMVEFP 951

  Fly   715 VSCQLGRMLIFGILLRCLDPILTIVSSLSTA----DPLGIPFTEDIDNLWDRFTIYIQNSIKKER 775
            :...|.:|||....:.|...||.|||.||..    .|.|  ..|:.|.:.::|.:
Mouse   952 LDPALSKMLIVSCDMGCSSEILLIVSMLSVPAIFYRPKG--REEESDQIREKFAV---------- 1004

  Fly   776 TYLSDNQFSDHFIFVRLYKEWQNRMHNRTPPLYLKD------------EYEFMLNGLM-EQLTSI 827
                  ..|||..::.:|.:|:|   |....::..|            |....|..:| :|..|:
Mouse  1005 ------PESDHLTYLNVYLQWKN---NNYSTIWCNDHFIHAKAMRKVREVRAQLKDIMVQQRMSL 1060

  Fly   828 RS-----EIVSSLRAANLIHSRGKLS-----MNNLNQMSCNWHMVKAALTGGMYPN 873
            .|     :||.....|...|...||.     :|....|.|:.|...:....|..|:
Mouse  1061 ASCGTDWDIVRKCICAAYFHQAAKLKGIGEYVNIRTGMPCHLHPTSSLFGMGYTPD 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	2/31 (6%)
		ANK	407..>460	CDD:238125	3/52 (6%)
		Ank_2	413..>460	CDD:289560	1/46 (2%)
		HrpA	<484..973	CDD:224557	100/438 (23%)
		HA2	694..763	CDD:214852	21/72 (29%)
		OB_NTP_bind	823..945	CDD:285018	15/61 (25%)
Dhx38	NP_848467.1	DEXDc	527..714	CDD:214692	43/341 (13%)
		DEXDc	552..688	CDD:238005	31/161 (19%)
		HELICc	759..862	CDD:197757	22/121 (18%)
		HA2	931..1013	CDD:214852	25/99 (25%)
		OB_NTP_bind	<1064..1147	CDD:285018	12/53 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810