DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and dhx8

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	XP_002663993.1	Gene:	dhx8 / 606595	ZFINID:	ZDB-GENE-050809-39	Length:	1210	Species:	Danio rerio

Alignment Length:	985	Identity:	184/985 - (18%)
Similarity:	331/985 - (33%)	Gaps:	363/985 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 PKTLVLSSGATLNMFTLLSRKSLMGKEDLELYADLVSMKANASDLPSLHL--------PLP---- 127
            |..:|.:...:|:...::  :|.:.||..|     |......:::.|:.:        |||
Zfish   451 PVKIVKNPDGSLSQAAMM--QSALAKERRE-----VKQAQREAEMDSIPMGLNKHWVDPLPDVDG 508

  Fly   128 ----------AIRPPNLRFW-------------TEAQLNFL---TAFLGHSLSDEILQSLYASRV 166
                      .:.|.::..|             .:.||:.|   .:...:.|.::::|:::.:::
Zfish   509 RQIAANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQLSILEQRESLPIYKLKEQLIQAVHDNQI 573

  Fly   167 IVYNAALCWDKSVFLPLVILDDCRNKKSNV-------------KIMCIERQAILATYNSQRTANF 218
            ::               ||.:....|.:.:             ||.|.:.:.:.|...::|.:..
Zfish   574 LI---------------VIGETGSGKTTQITQYLAEAGYTTRGKIGCTQPRRVAAMSVAKRVSEE 623

  Fly   219 FGEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLRS-LTSQQFRNISHLVVNDVHLHDPYTDILL 282
            :|..||:.||..:.:....|..|.|.|.|....||. |........:.:::::.|....:||:|.
Zfish   624 YGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLGQYAIIMLDEAHERTIHTDVLF 688

  Fly   283 SEIRMALSSHQNLRVVLLSQMGNPKKFTDFFGEG-----------LQLNMIKQPEVAPRVSYLNE 336
            ..::..:....::::::.|...:..||:.:|.|.           :::...|:||    ..||:.
Zfish   689 GLLKKTVQKRTDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEVLYTKEPE----TDYLDA 749

  Fly   337 LHSCIALAGIHKGPDIYKEIPEAFRANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVN 401
              |.|.:..||              ...|                                 |.:
Zfish   750 --SLITVMQIH--------------LTEP---------------------------------PGD 765

  Fly   402 YRHSLTGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLH 466
            ....|||:..:..|.|:                    |:::
Zfish   766 ILVFLTGQEEIDTACEI--------------------LYER------------------------ 786

  Fly   467 GYVVKSAKPDFVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGS 531
               :||..||.                ||           |||||.|            ..|...
Zfish   787 ---MKSLGPDV----------------PE-----------LIILPVY------------SALPSE 809

  Fly   532 LQECSIFLLYDNMRNDYLQALVNASDETVKVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTS 596
            :|.    .::|           .|...:.|||:||:|.|:........|.:|.......||:  |
Zfish   810 MQT----RIFD-----------PAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYN--S 857

  Fly   597 CSGDDRFEWVAKDALLRRELILQP--------------NKGDVQCFRLISKEAY-EELSETSQPS 646
            .:|.|             :|::.|              ..|..:|:||.::.|| :|:..|:.|.
Zfish   858 KTGID-------------QLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPE 909

  Fly   647 LQTMQLDKICLAVKLLSPNTIIS-EYLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRL 710
            :|...|....|::|.:..|.::| :::    ..||:..:..|::.|..:..|||...:|.||.|:
Zfish   910 IQRTNLASTVLSLKAMGINDLLSFDFM----DAPPMETLITAMEQLYTLGALDDEGLLTRLGRRM 970

  Fly   711 MDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKKER 775
            .:.|:...|.:|||..:.|.|.:.:|||||.||            :.|::.|         .|::
Zfish   971 AEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLS------------VQNVFYR---------PKDK 1014

  Fly   776 TYLSDNQFS-------DHFIFVRLYKEWQNRMHNRTPPLYLKDEYEFMLNGLMEQLTSIRSEIVS 833
            ..|:|.:.:       ||...:.:|..|:|...: .|..|             |.....|
Zfish  1015 QALADQKKAKFHQPEGDHLTLLAVYNSWKNNKFS-NPWCY-------------ENFIQAR----- 1060

  Fly   834 SLRAANLIHSR--GKLSMNNLNQMSCNWHMVKA--ALTGGMYPNIYAVDTRKSSLKSAFSGNVSM 894
            |||.|..|..:  |.:..:.|:.:||....|:.  |:..|.:.|....|.::..........|.:
Zfish  1061 SLRRAQDIRKQMLGIMDRHKLDVVSCGKATVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYI 1125

  Fly   895 HPNTVLRDFLEPLNISAQSFRTPWIVCNRQKSHIVYATLV------------------VPLAVAM 941
            ||::.|                    .|||...:||..||                  |..|.|.
Zfish  1126 HPSSAL--------------------FNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAF 1170

  Fly   942 FSGHPRIRLS 951
            |......|||
Zfish  1171 FKVSDPTRLS 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	5/31 (16%)
		ANK	407..>460	CDD:238125	5/52 (10%)
		Ank_2	413..>460	CDD:289560	3/46 (7%)
		HrpA	<484..973	CDD:224557	114/513 (22%)
		HA2	694..763	CDD:214852	22/68 (32%)
		OB_NTP_bind	823..945	CDD:285018	30/143 (21%)
dhx8	XP_002663993.1	S1_DHX8_helicase	257..333	CDD:240189
dhx8	XP_002663993.1	HrpA	542..1209	CDD:224557	170/887 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810